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Report error Found 9974 Enz. Inhib. hit(s) with Target = 'Prostaglandin G/H synthase 2'
TargetProstaglandin G/H synthase 2(Human)
University of Michigan Medical School

LigandPNGBDBM209868(Heme | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,...)
Affinity DataKd:  160nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2 [Y385F](Human)
University of Michigan Medical School

LigandPNGBDBM209868(Heme | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,...)
Affinity DataKd:  370nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2 [R120A,Y385F](Human)
University of Michigan Medical School

LigandPNGBDBM209868(Heme | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,...)
Affinity DataKd:  620nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2 [S530A](Human)
University of Michigan Medical School

LigandPNGBDBM209868(Heme | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,...)
Affinity DataKd:  240nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM22319([1-14C]Arachidonic acid | (5Z,8Z,11Z,14Z)-icosa-5,...)
Affinity DataKd:  8.07E+3nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM222288(2-(Methoxycarbonylmethyl)-4-(benzo[d][1,3]dioxol-5...)
Affinity DataKd:  230nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM222289(4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-pyrrolidin-1-yl-...)
Affinity DataKd:  51.3nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM222290(4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-morpholin-4-yl-2...)
Affinity DataKd:  203nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM222291(4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-piperidin-1-yl-2...)
Affinity DataKd:  51.1nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM222292(4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-(3-methylpiperid...)
Affinity DataKd:  40.8nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM222293(4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-(3,4-dimethoxyph...)
Affinity DataKd:  14.0nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM222294(4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-(4-methylpiperaz...)
Affinity DataKd:  56.4nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM222295(4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-(4-phenylpiperaz...)
Affinity DataKd:  3.30nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM222296(4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-(4-(4-fluorophen...)
Affinity DataKd:  3.30nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataKd:  1.02E+3nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataKd:  789nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50427217(CHEMBL2324850)
Affinity DataKd:  652nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50486823(CHEMBL2235866)
Affinity DataKd:  448nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50486824(CHEMBL2235864)
Affinity DataKd:  227nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataKd:  92nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50486825(CHEMBL2235865)
Affinity DataKd:  50nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50486822(CHEBI:76249 | Miroprofen)
Affinity DataKd:  48nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human recombinant COX2 using arachidonic acid as substrate measured after 5 mins by ADHP reagent based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50514417(CHEMBL4540374)
Affinity DataKd:  10nMAssay Description:Binding affinity to human COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50366159(CHEMBL1957450)
Affinity DataKd:  0.190nMAssay Description:Binding affinity to COX2 by surface plasmon resonance spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50382193(CHEMBL2023846)
Affinity DataEC50:  330nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50272095(4-(3-(4-methoxyphenyl)-1H-indol-2-yl)benzenesulfon...)
Affinity DataIC50: 0.00603nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50272095(4-(3-(4-methoxyphenyl)-1H-indol-2-yl)benzenesulfon...)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50272095(4-(3-(4-methoxyphenyl)-1H-indol-2-yl)benzenesulfon...)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50272096(3-(4-methoxyphenyl)-2-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272129(4-(5-methyl-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272131(3-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-1H...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50272131(3-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-1H...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50272129(4-(5-methyl-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50272096(3-(4-methoxyphenyl)-2-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50272125(4-(3-p-tolyl-1H-indol-2-yl)benzenesulfonamide | CH...)
Affinity DataIC50: 0.0692nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50272125(4-(3-p-tolyl-1H-indol-2-yl)benzenesulfonamide | CH...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50094539(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.1.0*2...)
Affinity DataIC50: 0.0800nMAssay Description:Tested in vitro for inhibition against Prostaglandin G/H synthase 2 in human blood (95% confidence limits)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50272105(4-(3-phenyl-1H-indol-2-yl)benzenesulfonamide | CHE...)
Affinity DataIC50: 0.0891nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272126(2-(4-(methylsulfonyl)phenyl)-3-p-tolyl-1H-indole |...)
Affinity DataIC50: 0.0891nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50272105(4-(3-phenyl-1H-indol-2-yl)benzenesulfonamide | CHE...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50272126(2-(4-(methylsulfonyl)phenyl)-3-p-tolyl-1H-indole |...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50094551(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.2.0*2...)
Affinity DataIC50: 0.120nMAssay Description:Tested in vitro for inhibition against Prostaglandin G/H synthase 2 in human blood (95% confidence limits)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition by colorimetric assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50272110(4-(5-chloro-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50272110(4-(5-chloro-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50: 0.141nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272097(3-(3,4-dimethylphenyl)-2-(4-(methylsulfonyl)phenyl...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50272097(3-(3,4-dimethylphenyl)-2-(4-(methylsulfonyl)phenyl...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50272128(N-(4-(3-phenyl-1H-indol-2-yl)phenylsulfonyl)acetam...)
Affinity DataIC50: 0.178nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
Panjab University

LigandPNGBDBM50272128(N-(4-(3-phenyl-1H-indol-2-yl)phenylsulfonyl)acetam...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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