Compile Data Set for Download or QSAR
Found 540 Enz. Inhib. hit(s) with Target = 'Proteinase-activated receptor 2'
TargetProteinase-activated receptor 2(RAT)
The University of Calgary

Curated by PDSP Ki Database
LigandPNGBDBM85518(tc-NH2 | trans-cinnamoyl-LIGRLO-NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)C=Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN)C(N)=O
Show InChI InChI=1S/C40H67N11O7/c1-7-26(6)34(51-38(57)30(21-24(2)3)48-32(52)18-17-27-13-9-8-10-14-27)39(58)46-23-33(53)47-29(16-12-20-45-40(43)44)36(55)50-31(22-25(4)5)37(56)49-28(35(42)54)15-11-19-41/h8-10,13-14,17-18,24-26,28-31,34H,7,11-12,15-16,19-23,41H2,1-6H3,(H2,42,54)(H,46,58)(H,47,53)(H,48,52)(H,49,56)(H,50,55)(H,51,57)(H4,43,44,45)/t26-,28-,29-,30-,31-,34-/m0/s1
Affinity DataKi:  260nMMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(RAT)
The University of Calgary

Curated by PDSP Ki Database
LigandPNGBDBM85517(CAS_171436-38-7 | SL-NH2 | SLIGRL-NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(N)=O
Show InChI InChI=1S/C29H56N10O7/c1-7-17(6)23(39-27(45)21(12-16(4)5)38-25(43)18(30)14-40)28(46)35-13-22(41)36-19(9-8-10-34-29(32)33)26(44)37-20(24(31)42)11-15(2)3/h15-21,23,40H,7-14,30H2,1-6H3,(H2,31,42)(H,35,46)(H,36,41)(H,37,44)(H,38,43)(H,39,45)(H4,32,33,34)/t17-,18-,19-,20-,21-,23-/m0/s1
Affinity DataKi:  260nMMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440869(CHEMBL2431727)
Show SMILES NCCCC[C@H](NC(=O)CNC(=O)Nc1ccc2n(Cc3c(Cl)cccc3Cl)cc(CN3CCCC3)c2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C51H56Cl2N8O4/c52-42-21-14-22-43(53)41(42)34-61-33-38(32-60-27-12-13-28-60)40-30-39(24-25-46(40)61)56-51(65)55-31-47(62)57-44(23-10-11-26-54)49(63)58-45(29-35-15-4-1-5-16-35)50(64)59-48(36-17-6-2-7-18-36)37-19-8-3-9-20-37/h1-9,14-22,24-25,30,33,44-45,48H,10-13,23,26-29,31-32,34,54H2,(H,57,62)(H,58,63)(H,59,64)(H2,55,56,65)/t44-,45-/m0/s1
Affinity DataKi:  600nMAssay Description:Displacement of [3H]2-furoyl-LIGRL-NH2 from human PAR2 expressed in human NCTC-2544 cells by scintillation counting analysisMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50134199(CHEMBL3735057)
Show SMILES NCCCC[C@H](NC(=O)CNC(=O)Nc1ccc2n(Cc3c(Cl)cccc3Cl)cc(CN3CCCC3)c2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C51H56Cl2N8O4/c52-42-21-14-22-43(53)41(42)34-61-33-38(32-60-27-12-13-28-60)40-30-39(24-25-46(40)61)56-51(65)55-31-47(62)57-44(23-10-11-26-54)49(63)58-45(29-35-15-4-1-5-16-35)50(64)59-48(36-17-6-2-7-18-36)37-19-8-3-9-20-37/h1-9,14-22,24-25,30,33,44-45,48H,10-13,23,26-29,31-32,34,54H2,(H,57,62)(H,58,63)(H,59,64)(H2,55,56,65)/t44-,45+/m0/s1
Affinity DataKi:  627nMAssay Description:Displacement of [3H]furoyl-LIGRL-NH2 from human protease-activated receptor 2 in NCTC-2544 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50134200(CHEMBL3735405)
Show SMILES NCC[C@H](NC(=O)CNC(=O)Nc1ccc2n(Cc3c(Cl)cccc3Cl)cc(CN3CCCC3)c2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C42H46Cl2N8O4/c43-34-14-9-15-35(44)33(34)27-52-26-29(25-51-20-7-8-21-51)32-23-31(16-17-38(32)52)48-42(56)46-24-39(53)49-36(18-19-45)40(54)50-37(22-28-10-3-1-4-11-28)41(55)47-30-12-5-2-6-13-30/h1-6,9-17,23,26,36-37H,7-8,18-22,24-25,27,45H2,(H,47,55)(H,49,53)(H,50,54)(H2,46,48,56)/t36-,37+/m0/s1
Affinity DataKi:  1.94E+3nMAssay Description:Displacement of [3H]furoyl-LIGRL-NH2 from human protease-activated receptor 2 in NCTC-2544 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(RAT)
The University of Calgary

Curated by PDSP Ki Database
LigandPNGBDBM85516(CAS_141923-41-3 | P5-NH2 | SFLLR-NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C30H51N9O6/c1-17(2)13-22(27(43)36-21(25(32)41)11-8-12-35-30(33)34)38-28(44)23(14-18(3)4)39-29(45)24(37-26(42)20(31)16-40)15-19-9-6-5-7-10-19/h5-7,9-10,17-18,20-24,40H,8,11-16,31H2,1-4H3,(H2,32,41)(H,36,43)(H,37,42)(H,38,44)(H,39,45)(H4,33,34,35)/t20-,21-,22-,23-,24-/m0/s1
Affinity DataKi:  2.30E+3nMMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(RAT)
The University of Calgary

Curated by PDSP Ki Database
LigandPNGBDBM85088(SFLLR-OH)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C30H50N8O7/c1-17(2)13-22(26(41)35-21(29(44)45)11-8-12-34-30(32)33)37-27(42)23(14-18(3)4)38-28(43)24(36-25(40)20(31)16-39)15-19-9-6-5-7-10-19/h5-7,9-10,17-18,20-24,39H,8,11-16,31H2,1-4H3,(H,35,41)(H,36,40)(H,37,42)(H,38,43)(H,44,45)(H4,32,33,34)/t20-,21-,22-,23-,24-/m0/s1
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50503927(CHEMBL4470628)
Show SMILES CC(C)c1cc(nn2cc(nc12)C(=O)N1CCN(CC1(C)C)C(=O)CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C26H30FN5O4/c1-16(2)19-13-20(17-5-7-18(27)8-6-17)29-32-14-21(28-24(19)32)25(36)31-12-11-30(15-26(31,3)4)22(33)9-10-23(34)35/h5-8,13-14,16H,9-12,15H2,1-4H3,(H,34,35)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at PAR2 in human EAhy926 cells assessed as inhibition of trypsin-induced intracellular calcium mobilization preincubated for 15 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50091326(CHEMBL3582248)
Show SMILES CC(C)c1cc(nn2cc(nc12)C(=O)N1CCN(CC1(C)C)C(=O)OC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H34FN5O3/c1-17(2)20-14-21(18-8-10-19(28)11-9-18)30-33-15-22(29-23(20)33)24(34)32-13-12-31(16-27(32,6)7)25(35)36-26(3,4)5/h8-11,14-15,17H,12-13,16H2,1-7H3
Affinity DataIC50: 2nMAssay Description:Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of SLIGKV-induced Ca2+ responses pre-incubated for 30 mins before SLIGKV ...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50091328(CHEMBL3582250)
Show SMILES CC(C)c1cc(nn2cc(nc12)C(=O)N1CCN([C@@H](C)C1)C(=O)Cc1ccsc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN5O2S/c1-17(2)22-13-23(20-4-6-21(28)7-5-20)30-33-15-24(29-26(22)33)27(35)31-9-10-32(18(3)14-31)25(34)12-19-8-11-36-16-19/h4-8,11,13,15-18H,9-10,12,14H2,1-3H3/t18-/m0/s1
Affinity DataIC50: 2nMAssay Description:Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of SLIGKV-induced Ca2+ responses pre-incubated for 30 mins before SLIGKV ...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50274114(CHEMBL4128763)
Show SMILES C[C@@H](C1CCCCC1)n1c(nc2cc(ccc12)C(=O)Nc1ccc(cc1)C#N)-c1cc2OCOc2cc1Br
Show InChI InChI=1S/C30H27BrN4O3/c1-18(20-5-3-2-4-6-20)35-26-12-9-21(30(36)33-22-10-7-19(16-32)8-11-22)13-25(26)34-29(35)23-14-27-28(15-24(23)31)38-17-37-27/h7-15,18,20H,2-6,17H2,1H3,(H,33,36)/t18-/m0/s1
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human PAR2More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50091327(CHEMBL3582251)
Show SMILES CC(C)(C)OC(=O)N1CCN(C(=O)c2cn3nc(cc(c3n2)C(C)(C)C)-c2ccc(F)cc2)C(C)(C)C1
Show InChI InChI=1S/C28H36FN5O3/c1-26(2,3)20-15-21(18-9-11-19(29)12-10-18)31-34-16-22(30-23(20)34)24(35)33-14-13-32(17-28(33,7)8)25(36)37-27(4,5)6/h9-12,15-16H,13-14,17H2,1-8H3
Affinity DataIC50: 4.20nMAssay Description:Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of SLIGKV-induced Ca2+ responses pre-incubated for 30 mins before SLIGKV ...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50091327(CHEMBL3582251)
Show SMILES CC(C)(C)OC(=O)N1CCN(C(=O)c2cn3nc(cc(c3n2)C(C)(C)C)-c2ccc(F)cc2)C(C)(C)C1
Show InChI InChI=1S/C28H36FN5O3/c1-26(2,3)20-15-21(18-9-11-19(29)12-10-18)31-34-16-22(30-23(20)34)24(35)33-14-13-32(17-28(33,7)8)25(36)37-27(4,5)6/h9-12,15-16H,13-14,17H2,1-8H3
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of trypsin-induced Ca2+ responses pre-incubated for 30 mins before trypsi...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50091326(CHEMBL3582248)
Show SMILES CC(C)c1cc(nn2cc(nc12)C(=O)N1CCN(CC1(C)C)C(=O)OC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H34FN5O3/c1-17(2)20-14-21(18-8-10-19(28)11-9-18)30-33-15-22(29-23(20)33)24(34)32-13-12-31(16-27(32,6)7)25(35)36-26(3,4)5/h8-11,14-15,17H,12-13,16H2,1-7H3
Affinity DataIC50: 5nMAssay Description:Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of trypsin-induced Ca2+ responses pre-incubated for 30 mins before trypsi...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50091328(CHEMBL3582250)
Show SMILES CC(C)c1cc(nn2cc(nc12)C(=O)N1CCN([C@@H](C)C1)C(=O)Cc1ccsc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN5O2S/c1-17(2)22-13-23(20-4-6-21(28)7-5-20)30-33-15-24(29-26(22)33)27(35)31-9-10-32(18(3)14-31)25(34)12-19-8-11-36-16-19/h4-8,11,13,15-18H,9-10,12,14H2,1-3H3/t18-/m0/s1
Affinity DataIC50: 5nMAssay Description:Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of trypsin-induced Ca2+ responses pre-incubated for 30 mins before trypsi...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50241049(CHEMBL463763 | Triptolide, 1 | triptolide)
Show SMILES CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3C[C@H]3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O
Show InChI InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human PAR2 expressed in human A549 cells assessed as inhibition of 2f-LIGRLO-NH2-induced NFkappaB activation by luciferase rep...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50241049(CHEMBL463763 | Triptolide, 1 | triptolide)
Show SMILES CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3C[C@H]3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O
Show InChI InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human PAR2 expressed in human A549 cells coexpressing TACR1 assessed as inhibition of substance P-induced IL-8 production by E...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50503927(CHEMBL4470628)
Show SMILES CC(C)c1cc(nn2cc(nc12)C(=O)N1CCN(CC1(C)C)C(=O)CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C26H30FN5O4/c1-16(2)19-13-20(17-5-7-18(27)8-6-17)29-32-14-21(28-24(19)32)25(36)31-12-11-30(15-26(31,3)4)22(33)9-10-23(34)35/h5-8,13-14,16H,9-12,15H2,1-4H3,(H,34,35)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at PAR2 in human EAhy926 cells assessed as inhibition of SLIGKV-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440863(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
Affinity DataIC50: 100nMAssay Description:Agonist activity at human PAR2 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 20 mins followed by...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50412718(CHEMBL509819)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)c1ccco1)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN)C(N)=O
Show InChI InChI=1S/C36H63N11O8/c1-7-22(6)29(47-33(52)26(18-21(4)5)46-34(53)27-13-10-16-55-27)35(54)42-19-28(48)43-24(12-9-15-41-36(39)40)31(50)45-25(17-20(2)3)32(51)44-23(30(38)49)11-8-14-37/h10,13,16,20-26,29H,7-9,11-12,14-15,17-19,37H2,1-6H3,(H2,38,49)(H,42,54)(H,43,48)(H,44,51)(H,45,50)(H,46,53)(H,47,52)(H4,39,40,41)/t22-,23-,24-,25-,26-,29-/m0/s1
Affinity DataIC50: 100nMAssay Description:Displacement of [3H]-2-furoyl-LIGRL-NH2 from human PAR2 expressed in human NCTC-2544 cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440863(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
Affinity DataIC50: 109nMAssay Description:Agonist activity at human PAR2 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 20 mins followed by...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440858(CHEMBL2431721)
Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(O)=O
Show InChI InChI=1S/C99H179N29O31S/c1-7-9-10-11-12-13-14-15-16-17-18-19-20-37-75(134)113-59(35-29-47-109-98(105)106)82(143)125-73(55-132)95(156)127-71(53-130)93(154)111-57(4)80(141)114-66(42-49-160-6)89(150)123-69(51-78(139)140)91(152)119-65(39-41-77(137)138)88(149)122-68(50-74(104)133)90(151)126-72(54-131)94(155)120-64(38-40-76(135)136)87(148)117-61(32-22-26-44-101)83(144)115-60(31-21-25-43-100)84(145)118-63(36-30-48-110-99(107)108)85(146)116-62(33-23-27-45-102)86(147)124-70(52-129)92(153)112-58(5)81(142)128-79(56(3)8-2)96(157)121-67(97(158)159)34-24-28-46-103/h56-73,79,129-132H,7-55,100-103H2,1-6H3,(H2,104,133)(H,111,154)(H,112,153)(H,113,134)(H,114,141)(H,115,144)(H,116,146)(H,117,148)(H,118,145)(H,119,152)(H,120,155)(H,121,157)(H,122,149)(H,123,150)(H,124,147)(H,125,143)(H,126,151)(H,127,156)(H,128,142)(H,135,136)(H,137,138)(H,139,140)(H,158,159)(H4,105,106,109)(H4,107,108,110)/t56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,79-/m0/s1
Affinity DataIC50: 140nMAssay Description:Antagonist activity at PAR2 in human neutrophils assessed as inhibition of chemotactic migration of cells towards trypsin/SLIGRL-NH2More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429560(US10550089, Example 34 | US10995072, Example 35)
Show SMILES CCc1ccc2c(F)ccc(C(O)c3ncc[nH]3)n12
Affinity DataIC50: 200nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429561(US10550089, Example 35 | US10995072, Example 36)
Show SMILES CCc1ccc2c(F)ccc([C@@H](O)c3ncc[nH]3)n12
Affinity DataIC50: 200nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429560(US10550089, Example 34 | US10995072, Example 35)
Show SMILES CCc1ccc2c(F)ccc(C(O)c3ncc[nH]3)n12
Affinity DataIC50: 300nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429560(US10550089, Example 34 | US10995072, Example 35)
Show SMILES CCc1ccc2c(F)ccc(C(O)c3ncc[nH]3)n12
Affinity DataIC50: 300nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429568(US10550089, Example 42 | US10995072, Example 42)
Show SMILES CCc1coc2c(F)ccc([C@H](O)c3ncc[nH]3)c12
Affinity DataIC50: 330nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429568(US10550089, Example 42 | US10995072, Example 42)
Show SMILES CCc1coc2c(F)ccc([C@H](O)c3ncc[nH]3)c12
Affinity DataIC50: 330nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)NCc1ccccc1OC
Show InChI InChI=1S/C27H38N4O5/c1-4-18(2)24(27(34)28-17-20-12-8-9-13-22(20)35-3)31-25(32)21(16-19-10-6-5-7-11-19)30-26(33)23-14-15-29-36-23/h8-9,12-15,18-19,21,24H,4-7,10-11,16-17H2,1-3H3,(H,28,34)(H,30,33)(H,31,32)/t18-,21-,24-/m0/s1
Affinity DataIC50: 400nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-induced intracellular calcium releaseMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50503927(CHEMBL4470628)
Show SMILES CC(C)c1cc(nn2cc(nc12)C(=O)N1CCN(CC1(C)C)C(=O)CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C26H30FN5O4/c1-16(2)19-13-20(17-5-7-18(27)8-6-17)29-32-14-21(28-24(19)32)25(36)31-12-11-30(15-26(31,3)4)22(33)9-10-23(34)35/h5-8,13-14,16H,9-12,15H2,1-4H3,(H,34,35)
Affinity DataIC50: 480nMAssay Description:Antagonist activity at PAR2 in human MDA-MB-231 cells assessed as inhibition of SLIGKV-NH2-induced intracellular calcium mobilization preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50091328(CHEMBL3582250)
Show SMILES CC(C)c1cc(nn2cc(nc12)C(=O)N1CCN([C@@H](C)C1)C(=O)Cc1ccsc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN5O2S/c1-17(2)22-13-23(20-4-6-21(28)7-5-20)30-33-15-24(29-26(22)33)27(35)31-9-10-32(18(3)14-31)25(34)12-19-8-11-36-16-19/h4-8,11,13,15-18H,9-10,12,14H2,1-3H3/t18-/m0/s1
Affinity DataIC50: 500nMAssay Description:Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of UTP-induced Ca2+ responses pre-incubated for 30 mins before UTP stimul...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)NCc1ccccc1OC
Show InChI InChI=1S/C27H38N4O5/c1-4-18(2)24(27(34)28-17-20-12-8-9-13-22(20)35-3)31-25(32)21(16-19-10-6-5-7-11-19)30-26(33)23-14-15-29-36-23/h8-9,12-15,18-19,21,24H,4-7,10-11,16-17H2,1-3H3,(H,28,34)(H,30,33)(H,31,32)/t18-,21-,24-/m0/s1
Affinity DataIC50: 500nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-induced ca2+ release preincubated for 15 mins measured after...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50091328(CHEMBL3582250)
Show SMILES CC(C)c1cc(nn2cc(nc12)C(=O)N1CCN([C@@H](C)C1)C(=O)Cc1ccsc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN5O2S/c1-17(2)22-13-23(20-4-6-21(28)7-5-20)30-33-15-24(29-26(22)33)27(35)31-9-10-32(18(3)14-31)25(34)12-19-8-11-36-16-19/h4-8,11,13,15-18H,9-10,12,14H2,1-3H3/t18-/m0/s1
Affinity DataIC50: 500nMAssay Description:Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of thrombin-induced Ca2+ responses pre-incubated for 30 mins before throm...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)NCc1ccccc1OC
Show InChI InChI=1S/C27H38N4O5/c1-4-18(2)24(27(34)28-17-20-12-8-9-13-22(20)35-3)31-25(32)21(16-19-10-6-5-7-11-19)30-26(33)23-14-15-29-36-23/h8-9,12-15,18-19,21,24H,4-7,10-11,16-17H2,1-3H3,(H,28,34)(H,30,33)(H,31,32)/t18-,21-,24-/m0/s1
Affinity DataIC50: 501nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-induced ca2+ release preincubated for 15 mins measured after...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429576(US10550089, Example 50 | US10995072, Example 51)
Show SMILES CCc1csc2c(F)ccc([C@@H](O)c3ncc[nH]3)c12
Affinity DataIC50: 600nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429576(US10550089, Example 50 | US10995072, Example 51)
Show SMILES CCc1csc2c(F)ccc([C@@H](O)c3ncc[nH]3)c12
Affinity DataIC50: 600nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429569(US10550089, Example 43 | US10550089, Example 44 | ...)
Show SMILES OC(c1ncc[nH]1)c1ccc(F)c2occ(C3CC3)c12
Affinity DataIC50: 630nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM495079(US10995072, Example 45)
Show SMILES O[C@H](c1ncc[nH]1)c1ccc(F)c2occ(C3CC3)c12
Affinity DataIC50: 630nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50134198(CHEMBL1684609)
Show SMILES CCCCCNc1nc(NCc2ccco2)c2cc(F)ccc2n1
Show InChI InChI=1S/C18H21FN4O/c1-2-3-4-9-20-18-22-16-8-7-13(19)11-15(16)17(23-18)21-12-14-6-5-10-24-14/h5-8,10-11H,2-4,9,12H2,1H3,(H2,20,21,22,23)
Affinity DataIC50: 690nMAssay Description:Antagonist activity at protease-activated receptor 2 (unknown origin) expressed in CHO-K1 cells assessed as inhibition of trypsin-induced calcium flu...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440863(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
Affinity DataIC50: 700nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-induced intracellular calcium releaseMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440863(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
Affinity DataIC50: 700nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429566(US10550089, Example 40 | US10995072, Example 63)
Show SMILES CCc1coc2c(F)ccc(C(O)c3ncc[nH]3)c12
Affinity DataIC50: 750nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429566(US10550089, Example 40 | US10995072, Example 63)
Show SMILES CCc1coc2c(F)ccc(C(O)c3ncc[nH]3)c12
Affinity DataIC50: 750nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440863(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
Affinity DataIC50: 794nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50503930(CHEMBL4588926)
Show SMILES COCc1cn(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2CCN(C(=O)c3cn4nc(cc(C(C)C)c4n3)-c3ccc(F)cc3)C(C)(C)C2)nn1
Show InChI InChI=1S/C52H80FN9O14/c1-41(2)45-36-46(42-6-8-43(53)9-7-42)57-62-38-47(55-50(45)62)51(65)61-14-13-59(40-52(61,3)4)49(64)11-10-48(63)54-12-16-67-18-20-69-22-24-71-26-28-73-30-32-75-34-35-76-33-31-74-29-27-72-25-23-70-21-19-68-17-15-60-37-44(39-66-5)56-58-60/h6-9,36-38,41H,10-35,39-40H2,1-5H3,(H,54,63)
Affinity DataIC50: 860nMAssay Description:Antagonist activity at PAR2 in human MDA-MB-231 cells assessed as inhibition of SLIGKV-NH2-induced intracellular calcium mobilization preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429569(US10550089, Example 43 | US10550089, Example 44 | ...)
Show SMILES OC(c1ncc[nH]1)c1ccc(F)c2occ(C3CC3)c12
Affinity DataIC50: 860nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429569(US10550089, Example 43 | US10550089, Example 44 | ...)
Show SMILES OC(c1ncc[nH]1)c1ccc(F)c2occ(C3CC3)c12
Affinity DataIC50: 860nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429544(US10550089, Example 18 | US10995072, Example 18)
Show SMILES O[C@@H](c1ncc[nH]1)c1ccc(F)cc1N1CC=CC1
Affinity DataIC50: 900nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429586(US10550089, Example 60 | US10995072, Example 60)
Show SMILES CCc1ccn2c(F)ccc(C(O)c3ncc[nH]3)c12
Affinity DataIC50: 900nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM429585(US10550089, Example 59 | US10995072, Example 59)
Show SMILES Cc1cccc2c(F)ccc(C(O)c3ncc[nH]3)c12
Affinity DataIC50: 900nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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