Compile Data Set for Download or QSAR
Found 7 Enz. Inhib. hit(s) with Target = 'Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma'
LigandPNGBDBM14397(5-(5-acetyl-2-ethoxyphenyl)-1-methyl-3-propyl-1H,6...)
Affinity DataIC50:  0.900nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14396(5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-...)
Affinity DataIC50:  1.40nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  33nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14394(5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(pyrid...)
Affinity DataIC50:  183nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14392(3-ethyl-5-{5-[(4-ethylpiperazine-1-)sulfonyl]-2-(2...)
Affinity DataIC50:  386nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14393(5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(1-eth...)
Affinity DataIC50:  840nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14395(5-[2-Butoxy-5-(1-hydroxyethyl)-3-pyridinyl]-3-ethy...)
Affinity DataIC50: >3.00E+3nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed