Compile Data Set for Download or QSAR
Found 79 Enz. Inhib. hit(s) with Target = 'Ribonuclease pancreatic'
TargetRibonuclease pancreatic(Homo sapiens (Human))
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50402338(CHEMBL401150)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)O[P@@](O)(=O)O[C@H]2C[C@@H](O[C@@H]2COP(O)(O)=O)n2ccc(=O)[nH]c2=O)[C@@H](OP(O)(O)=O)[C@H]1O
Show InChI InChI=1S/C19H27N7O20P4/c20-16-13-17(22-6-21-16)26(7-23-13)18-14(28)15(45-48(33,34)35)10(43-18)5-41-49(36,37)46-50(38,39)44-8-3-12(25-2-1-11(27)24-19(25)29)42-9(8)4-40-47(30,31)32/h1-2,6-10,12,14-15,18,28H,3-5H2,(H,36,37)(H,38,39)(H2,20,21,22)(H,24,27,29)(H2,30,31,32)(H2,33,34,35)/t8-,9+,10+,12+,14+,15+,18+/m0/s1
Affinity DataKi:  27nMAssay Description:Inhibition of RNase AMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50342010(5'-phospho-2'-deoxyuridine-3'-pyrophosphate(P'->5'...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](OP(O)(=O)OC[C@H]2O[C@H](C[C@@H]2OP(O)(=O)OP(O)(O)=O)n2ccc(=O)[nH]c2=O)[C@H]1O
Show InChI InChI=1S/C19H26N7O17P3/c20-16-13-17(22-6-21-16)26(7-23-13)18-14(29)15(9(4-27)40-18)42-45(34,35)38-5-10-8(41-46(36,37)43-44(31,32)33)3-12(39-10)25-2-1-11(28)24-19(25)30/h1-2,6-10,12,14-15,18,27,29H,3-5H2,(H,34,35)(H,36,37)(H2,20,21,22)(H,24,28,30)(H2,31,32,33)/t8-,9+,10+,12+,14+,15+,18+/m0/s1
Affinity DataKi:  27nMpH: 5.9Assay Description:Inhibition of bovine pancreatic RNase A at pH 5.9 by spectrophotometric methodMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Homo sapiens (Human))
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50292713(5'-phospho-2'-deoxyuridine 3-pyrophosphate (P'->5'...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H](C[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H]1O
Show InChI InChI=1S/C19H25N7O14P2/c20-16-13-17(22-6-21-16)26(7-23-13)18-14(30)15(9(4-27)38-18)39-42(34,35)40-41(32,33)36-5-10-8(28)3-12(37-10)25-2-1-11(29)24-19(25)31/h1-2,6-10,12,14-15,18,27-28,30H,3-5H2,(H,32,33)(H,34,35)(H2,20,21,22)(H,24,29,31)/t8-,9+,10+,12+,14+,15+,18+/m0/s1
Affinity DataKi:  27nMAssay Description:Inhibition of RNase AMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50292721(CHEMBL504858 | [({[(2R,3S,4R,5R)-5-(6-amino-9H-pur...)
Show SMILES Cc1cn([C@H]2C[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3OP(O)(O)=O)n3cnc4c(N)ncnc34)[C@@H](COP(O)(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C20H29N7O20P4/c1-8-3-26(20(30)25-18(8)29)12-2-9(10(43-12)4-41-48(31,32)33)45-51(39,40)47-50(37,38)42-5-11-15(46-49(34,35)36)14(28)19(44-11)27-7-24-13-16(21)22-6-23-17(13)27/h3,6-7,9-12,14-15,19,28H,2,4-5H2,1H3,(H,37,38)(H,39,40)(H2,21,22,23)(H,25,29,30)(H2,31,32,33)(H2,34,35,36)/t9-,10+,11+,12+,14+,15+,19+/m0/s1
Affinity DataKi:  41nMAssay Description:Inhibition of bovine pancreatic RNase A by spectrophotometric methodMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50402337(CHEMBL2206660)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(Cn2ccc(=O)[nH]c2=O)nn1
Show InChI InChI=1S/C12H15N5O6/c18-5-7-9(20)10(21)11(23-7)17-4-6(14-15-17)3-16-2-1-8(19)13-12(16)22/h1-2,4,7,9-11,18,20-21H,3,5H2,(H,13,19,22)/t7-,9-,10-,11-/m1/s1
Affinity DataKi:  240nMAssay Description:Inhibition of bovine pancreatic RNase AMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50292724(CHEMBL460901 | URACIL ARABINOSE-3'-PHOSPHATE | ara...)
Show SMILES OC[C@H]1O[C@H]([C@@H](O)[C@@H]1OP(O)(O)=O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H13N2O9P/c12-3-4-7(20-21(16,17)18)6(14)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/t4-,6+,7-,8-/m1/s1
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of bovine pancreatic RNase A by spectrophotometric methodMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50298711((2R,3R,4R,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-...)
Show SMILES Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2OP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(20-21(16,17)18)6(14)4(3-13)19-8/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of bovine pancreatic RNase A by spectrophotometric assayMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50292723((2R,3R,4R,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(...)
Show SMILES OC[C@H]1O[C@H]([C@H](OP(O)(O)=O)[C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H13N2O9P/c12-3-4-6(14)7(20-21(16,17)18)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
Affinity DataKi:  7.10E+3nMAssay Description:Inhibition of bovine pancreatic RNase A by spectrophotometric methodMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50292723((2R,3R,4R,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(...)
Show SMILES OC[C@H]1O[C@H]([C@H](OP(O)(O)=O)[C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H13N2O9P/c12-3-4-6(14)7(20-21(16,17)18)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
Affinity DataKi:  1.16E+4nMpH: 6.0Assay Description:Inhibition of bovine pancreatic ribonuclease A assessed as enzyme activity by spectrophotometric method pH 6More data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Homo sapiens (Human))
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50375418(CHEMBL408119)
Show SMILES Cc1cn([C@H]2C[C@H](OP(O)(O)=O)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(7(4-13)19-8)20-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1
Affinity DataKi:  1.32E+4nMAssay Description:Activity at RNase AMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50233301(CHEMBL258728 | cytidine-3'-monophosphate)
Show SMILES Nc1ccn([C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]2O)c(=O)n1
Show InChI InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-6(14)7(4(3-13)19-8)20-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
Affinity DataKi:  2.01E+4nMpH: 6.0Assay Description:Inhibition of bovine pancreatic ribonuclease A assessed as enzyme activity by spectrophotometric method pH 6More data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50438455(CHEMBL2414522)
Show SMILES Cc1cn([C@H]2C[C@@H]([C@@H](CS(=O)(=O)CC(O)=O)O2)S(=O)(=O)CC(O)=O)c(=O)[nH]c1=O
Show InChI InChI=1S/C14H18N2O11S2/c1-7-3-16(14(22)15-13(7)21)10-2-9(29(25,26)6-12(19)20)8(27-10)4-28(23,24)5-11(17)18/h3,8-10H,2,4-6H2,1H3,(H,17,18)(H,19,20)(H,15,21,22)/t8-,9+,10-/m1/s1
Affinity DataKi:  2.50E+4nMAssay Description:Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50331790(3-Amino-N-[2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3...)
Show SMILES Cc1cn([C@H]2C[C@H](NC(=O)C(N)CC(O)=O)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C14H20N4O7/c1-6-4-18(14(24)17-12(6)22)10-3-8(9(5-19)25-10)16-13(23)7(15)2-11(20)21/h4,7-10,19H,2-3,5,15H2,1H3,(H,16,23)(H,20,21)(H,17,22,24)/t7?,8-,9+,10+/m0/s1
Affinity DataKi:  3.70E+4nMAssay Description:Competitive inhibition of bovine pancreatic RNase A ribonucleolytic activity of by Dixon plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50438453(CHEMBL2414524)
Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CS(=O)(=O)CC(O)=O)O2)S(=O)(=O)CC(O)=O)c(=O)[nH]c1=O
Show InChI InChI=1S/C14H18N2O11S2/c1-7-3-16(14(22)15-13(7)21)10-2-9(29(25,26)6-12(19)20)8(27-10)4-28(23,24)5-11(17)18/h3,8-10H,2,4-6H2,1H3,(H,17,18)(H,19,20)(H,15,21,22)/t8-,9-,10-/m1/s1
Affinity DataKi:  3.90E+4nMAssay Description:Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Homo sapiens (Human))
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50375420(CHEMBL266234)
Show SMILES CC(=O)O[C@H]1C[C@@H](O[C@@H]1CO)n1cc(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C12H16N2O6/c1-6-4-14(12(18)13-11(6)17)10-3-8(19-7(2)16)9(5-15)20-10/h4,8-10,15H,3,5H2,1-2H3,(H,13,17,18)/t8-,9+,10+/m0/s1
Affinity DataKi:  4.20E+4nMAssay Description:Activity at RNase AMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM173610(9-[3'-[4-[(Uracil-1-yl)methyl]-1,2,3-triazol-1...)
Show SMILES OC[C@H]1O[C@H](C(O)[C@H]1n1cc(Cn2ccc(=O)[nH]c2=O)nn1)n1cnc2c(NC(=O)c3ccccc3)ncnc12
Affinity DataKi:  5.55E+4nM ΔG°:  -24.7kJ/moleT: 2°CAssay Description:The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...More data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50342006(5'-Deoxy-5'-N-(4-carboxypiperidinyl)uridine | CHEM...)
Show SMILES O[C@@H]1[C@@H](CN2CCC(CC2)C(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C15H21N3O7/c19-10-3-6-18(15(24)16-10)13-12(21)11(20)9(25-13)7-17-4-1-8(2-5-17)14(22)23/h3,6,8-9,11-13,20-21H,1-2,4-5,7H2,(H,22,23)(H,16,19,24)/t9-,11-,12-,13-/m1/s1
Affinity DataKi:  6.10E+4nMAssay Description:Inhibition of bovine pancreatic RNase A using 2',3'-cCMP as a substrate by Dixon plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50331791((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydr...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(O)=O
Show InChI InChI=1S/C10H11N5O5/c11-7-3-8(13-1-12-7)15(2-14-3)9-5(17)4(16)6(20-9)10(18)19/h1-2,4-6,9,16-17H,(H,18,19)(H2,11,12,13)/t4-,5+,6-,9+/m0/s1
Affinity DataKi:  6.70E+4nMAssay Description:Competitive inhibition of bovine pancreatic RNase A ribonucleolytic activity of by Dixon plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM173614(9-[3'-[4-[(Thymine-1-yl)methyl]-1,2,3-triazol-...)
Show SMILES Cc1cn(Cc2cn(nn2)[C@H]2[C@@H](CO)O[C@H](C2O)N2C=NC3C2N=CN=C3N)c(=O)[nH]c1=O
Affinity DataKi:  6.88E+4nM ΔG°:  -24.2kJ/moleT: 2°CAssay Description:The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...More data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50342006(5'-Deoxy-5'-N-(4-carboxypiperidinyl)uridine | CHEM...)
Show SMILES O[C@@H]1[C@@H](CN2CCC(CC2)C(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C15H21N3O7/c19-10-3-6-18(15(24)16-10)13-12(21)11(20)9(25-13)7-17-4-1-8(2-5-17)14(22)23/h3,6,8-9,11-13,20-21H,1-2,4-5,7H2,(H,22,23)(H,16,19,24)/t9-,11-,12-,13-/m1/s1
Affinity DataKi:  7.50E+4nMAssay Description:Inhibition of bovine pancreatic RNase A using 2',3'-cCMP as a substrate by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50292715(5'-deoxy-5'-N-(ethyl isonipecotatyl)uridine | CHEM...)
Show SMILES CCOC(=O)C1CCN(C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)CC1
Show InChI InChI=1S/C17H25N3O7/c1-2-26-16(24)10-3-6-19(7-4-10)9-11-13(22)14(23)15(27-11)20-8-5-12(21)18-17(20)25/h5,8,10-11,13-15,22-23H,2-4,6-7,9H2,1H3,(H,18,21,25)/t11-,13-,14-,15-/m1/s1
Affinity DataKi:  7.70E+4nMAssay Description:Inhibition of bovine pancreatic RNase A by spectrophotometric methodMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50292722(3'-UMP | 3'-uridylic acid | CHEMBL460741)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H13N2O9P/c12-3-4-7(20-21(16,17)18)6(14)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
Affinity DataKi:  7.85E+4nMpH: 6.0Assay Description:Inhibition of bovine pancreatic ribonuclease A assessed as enzyme activity by spectrophotometric method pH 6More data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50298713(2',3'-Dideoxy-3'-L-serinylamino thymidine | CHEMBL...)
Show SMILES Cc1cn(C[C@H]2C[C@H](NC(=O)C(N)CO)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C14H22N4O6/c1-7-3-18(14(23)17-12(7)21)4-8-2-10(11(6-20)24-8)16-13(22)9(15)5-19/h3,8-11,19-20H,2,4-6,15H2,1H3,(H,16,22)(H,17,21,23)/t8-,9?,10+,11-/m1/s1
Affinity DataKi:  8.00E+4nMAssay Description:Inhibition of bovine pancreatic RNase A by spectrophotometric assayMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Homo sapiens (Human))
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM111444(Ser-aT (Compound 2))
Show SMILES Cc1cn([C@H]2C[C@@H](NC(=O)C(N)CO)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C13H20N4O6/c1-6-3-17(13(22)16-11(6)20)10-2-8(9(5-19)23-10)15-12(21)7(14)4-18/h3,7-10,18-19H,2,4-5,14H2,1H3,(H,15,21)(H,16,20,22)/t7?,8-,9-,10-/m1/s1
Affinity DataKi:  8.00E+4nMMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50292722(3'-UMP | 3'-uridylic acid | CHEMBL460741)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H13N2O9P/c12-3-4-7(20-21(16,17)18)6(14)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
Affinity DataKi:  8.20E+4nMAssay Description:Inhibition of bovine pancreatic RNase A by spectrophotometric methodMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50438456(CHEMBL2414521)
Show SMILES Cc1cn([C@H]2C[C@@H]([C@@H](CO)O2)S(=O)(=O)CC(O)=O)c(=O)[nH]c1=O
Show InChI InChI=1S/C12H16N2O8S/c1-6-3-14(12(19)13-11(6)18)9-2-8(7(4-15)22-9)23(20,21)5-10(16)17/h3,7-9,15H,2,4-5H2,1H3,(H,16,17)(H,13,18,19)/t7-,8+,9-/m1/s1
Affinity DataKi:  8.80E+4nMAssay Description:Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50438454(CHEMBL2414523)
Show SMILES Cc1cn([C@H]2C[C@H](SCC(O)=O)[C@@H](CSCC(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C14H18N2O7S2/c1-7-3-16(14(22)15-13(7)21)10-2-9(25-6-12(19)20)8(23-10)4-24-5-11(17)18/h3,8-10H,2,4-6H2,1H3,(H,17,18)(H,19,20)(H,15,21,22)/t8-,9+,10-/m1/s1
Affinity DataKi:  9.30E+4nMAssay Description:Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Homo sapiens (Human))
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50375419(CHEMBL259808)
Show SMILES Cc1cn([C@H]2C[C@H](OC(=O)c3ccccc3)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C17H18N2O6/c1-10-8-19(17(23)18-15(10)21)14-7-12(13(9-20)24-14)25-16(22)11-5-3-2-4-6-11/h2-6,8,12-14,20H,7,9H2,1H3,(H,18,21,23)/t12-,13+,14+/m0/s1
Affinity DataKi:  9.50E+4nMAssay Description:Activity at RNase AMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50438451(CHEMBL2414510)
Show SMILES Cc1cn([C@H]2C[C@H](O)[C@@H](CS(=O)(=O)CC(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C12H16N2O8S/c1-6-3-14(12(19)13-11(6)18)9-2-7(15)8(22-9)4-23(20,21)5-10(16)17/h3,7-9,15H,2,4-5H2,1H3,(H,16,17)(H,13,18,19)/t7-,8+,9+/m0/s1
Affinity DataKi:  9.50E+4nMAssay Description:Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM173612(9-[3'-[4-[(Cytosine-1-yl)methyl]-1,2,3-triazol...)
Show SMILES NC1=NC=NC2C1N=CN2[C@@H]1O[C@H](CO)[C@@H](C1O)n1cc(Cn2ccc(N)nc2=O)nn1
Show InChI InChI=1S/C17H21N11O4/c18-10-1-2-26(17(31)23-10)3-8-4-28(25-24-8)12-9(5-29)32-16(13(12)30)27-7-22-11-14(19)20-6-21-15(11)27/h1-2,4,6-7,9,11-13,15-16,29-30H,3,5H2,(H2,18,23,31)(H2,19,20,21)/t9-,11?,12+,13?,15?,16-/m1/s1
Affinity DataKi:  9.85E+4nM ΔG°:  -23.3kJ/moleT: 2°CAssay Description:The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...More data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Homo sapiens (Human))
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50276039(1-[3-(4-CARBOXYPIPERIDIN-1-YL)-3-DEOXY-BETA-D-ARAB...)
Show SMILES OC[C@H]1O[C@H]([C@@H](O)[C@@H]1N1CCC(CC1)C(O)=O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C15H21N3O7/c19-7-9-11(17-4-1-8(2-5-17)14(22)23)12(21)13(25-9)18-6-3-10(20)16-15(18)24/h3,6,8-9,11-13,19,21H,1-2,4-5,7H2,(H,22,23)(H,16,20,24)/t9-,11-,12+,13-/m1/s1
Affinity DataKi:  1.03E+5nMAssay Description:Inhibition of ribonucleolytic activity of RNase A (unknown origin) by agarose gel based assayMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50292714(3'-N-piperidine-4-carboxyl-3'-deoxyara-uridine | C...)
Show SMILES OC[C@]1(O[C@H]([C@@H](O)[C@@H]1N1CCCCC1)n1ccc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C15H21N3O7/c19-8-15(13(22)23)11(17-5-2-1-3-6-17)10(21)12(25-15)18-7-4-9(20)16-14(18)24/h4,7,10-12,19,21H,1-3,5-6,8H2,(H,22,23)(H,16,20,24)/t10-,11-,12+,15+/m0/s1
Affinity DataKi:  1.03E+5nMAssay Description:Inhibition of bovine pancreatic RNase A by spectrophotometric methodMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Homo sapiens (Human))
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50233301(CHEMBL258728 | cytidine-3'-monophosphate)
Show SMILES Nc1ccn([C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]2O)c(=O)n1
Show InChI InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-6(14)7(4(3-13)19-8)20-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
Affinity DataKi:  1.03E+5nMAssay Description:Activity at RNase AMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50233301(CHEMBL258728 | cytidine-3'-monophosphate)
Show SMILES Nc1ccn([C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]2O)c(=O)n1
Show InChI InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-6(14)7(4(3-13)19-8)20-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
Affinity DataKi:  1.03E+5nMAssay Description:Inhibition of bovine pancreatic RNase A by spectrophotometric methodMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50233301(CHEMBL258728 | cytidine-3'-monophosphate)
Show SMILES Nc1ccn([C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]2O)c(=O)n1
Show InChI InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-6(14)7(4(3-13)19-8)20-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
Affinity DataKi:  1.03E+5nMAssay Description:Inhibition of bovine pancreatic RNase A by spectrophotometric assayMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM173613(9-[3'-[4-[(Uracil-1-yl)methyl]-1,2,3-triazol-1...)
Show SMILES NC1=NC=NC2C1N=CN2[C@@H]1O[C@H](CO)[C@@H](C1O)n1cc(Cn2ccc(=O)[nH]c2=O)nn1
Affinity DataKi:  1.06E+5nM ΔG°:  -23.1kJ/moleT: 2°CAssay Description:The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...More data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50438452(CHEMBL2414509)
Show SMILES Cc1cn([C@H]2C[C@@H](SCC(O)=O)[C@@H](CSCC(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C14H18N2O7S2/c1-7-3-16(14(22)15-13(7)21)10-2-9(25-6-12(19)20)8(23-10)4-24-5-11(17)18/h3,8-10H,2,4-6H2,1H3,(H,17,18)(H,19,20)(H,15,21,22)/t8-,9-,10-/m1/s1
Affinity DataKi:  1.08E+5nMAssay Description:Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Homo sapiens (Human))
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50276040(3'-[1-(4-ethoxycarbonylpiperdinyl)]-3'-deoxy-ara-u...)
Show SMILES CCOC(=O)C1CCN(CC1)[C@@H]1[C@@H](CO)O[C@H]([C@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C17H25N3O7/c1-2-26-16(24)10-3-6-19(7-4-10)13-11(9-21)27-15(14(13)23)20-8-5-12(22)18-17(20)25/h5,8,10-11,13-15,21,23H,2-4,6-7,9H2,1H3,(H,18,22,25)/t11-,13-,14+,15-/m1/s1
Affinity DataKi:  1.20E+5nMAssay Description:Inhibition of ribonucleolytic activity of RNase A (unknown origin) by agarose gel based assayMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50342007(5'-Deoxy-5'-N-(4-carboxypiperidinyl)thymidine | CH...)
Show SMILES Cc1cn([C@H]2C[C@H](O)[C@@H](CN3CCC(CC3)C(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C16H23N3O6/c1-9-7-19(16(24)17-14(9)21)13-6-11(20)12(25-13)8-18-4-2-10(3-5-18)15(22)23/h7,10-13,20H,2-6,8H2,1H3,(H,22,23)(H,17,21,24)/t11-,12+,13+/m0/s1
Affinity DataKi:  1.21E+5nMAssay Description:Inhibition of bovine pancreatic RNase A using 2',3'-cCMP as a substrate by Dixon plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Homo sapiens (Human))
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM111446(N-[2-Hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihyd...)
Show SMILES Cc1cn([C@H]2C[C@@H](NC(=O)C(O)=O)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C12H15N3O7/c1-5-3-15(12(21)14-9(5)17)8-2-6(7(4-16)22-8)13-10(18)11(19)20/h3,6-8,16H,2,4H2,1H3,(H,13,18)(H,19,20)(H,14,17,21)/t6-,7-,8-/m1/s1
Affinity DataKi:  1.32E+5nMMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Homo sapiens (Human))
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50304292(2-((2S,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-di...)
Show SMILES Cc1cn([C@H]2C[C@H](NC(=O)C(O)=O)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C12H15N3O7/c1-5-3-15(12(21)14-9(5)17)8-2-6(7(4-16)22-8)13-10(18)11(19)20/h3,6-8,16H,2,4H2,1H3,(H,13,18)(H,19,20)(H,14,17,21)/t6-,7+,8+/m0/s1
Affinity DataKi:  1.32E+5nMAssay Description:Inhibition of RNase A using dixon plot by spectrophotometric methodMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50438448(CHEMBL2414513)
Show SMILES COC(=O)CS(=O)(=O)[C@H]1C[C@@H](O[C@@H]1CO)n1cc(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C13H18N2O8S/c1-7-4-15(13(19)14-12(7)18)10-3-9(8(5-16)23-10)24(20,21)6-11(17)22-2/h4,8-10,16H,3,5-6H2,1-2H3,(H,14,18,19)/t8-,9+,10-/m1/s1
Affinity DataKi:  1.40E+5nMAssay Description:Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM173611(9-[3'-[4-[(Thymine-1-yl)methyl]-1,2,3-triazol-...)
Show SMILES Cc1cn(Cc2cn(nn2)[C@H]2[C@@H](CO)O[C@H](C2O)n2cnc3c(NC(=O)c4ccccc4)ncnc23)c(=O)[nH]c1=O
Affinity DataKi:  1.50E+5nM ΔG°:  -22.2kJ/moleT: 2°CAssay Description:The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...More data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM173608(1-[3'-[4-[(Adenine-9-yl)methyl]-1,2,3-triazol-...)
Show SMILES Nc1ncnc2n(Cc3cn(nn3)[C@H]3[C@@H](CO)O[C@H](C3O)n3ccc(=O)[nH]c3=O)cnc12
Affinity DataKi:  1.59E+5nM ΔG°:  -22.0kJ/moleT: 2°CAssay Description:The Ribonuclease Activity assay used was adapted from the procedure described by Anfinsen et al. and Slifman et al. Determination of ribonuclease act...More data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50342007(5'-Deoxy-5'-N-(4-carboxypiperidinyl)thymidine | CH...)
Show SMILES Cc1cn([C@H]2C[C@H](O)[C@@H](CN3CCC(CC3)C(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C16H23N3O6/c1-9-7-19(16(24)17-14(9)21)13-6-11(20)12(25-13)8-18-4-2-10(3-5-18)15(22)23/h7,10-13,20H,2-6,8H2,1H3,(H,22,23)(H,17,21,24)/t11-,12+,13+/m0/s1
Affinity DataKi:  1.62E+5nMAssay Description:Inhibition of bovine pancreatic RNase A using 2',3'-cCMP as a substrate by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50438457(CHEMBL2414520)
Show SMILES Cc1cn([C@H]2C[C@H](SCC(O)=O)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C12H16N2O6S/c1-6-3-14(12(19)13-11(6)18)9-2-8(7(4-15)20-9)21-5-10(16)17/h3,7-9,15H,2,4-5H2,1H3,(H,16,17)(H,13,18,19)/t7-,8+,9-/m1/s1
Affinity DataKi:  1.69E+5nMAssay Description:Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50292719(5'-deoxy-5'-N-piperidinouridine | CHEMBL444258)
Show SMILES O[C@@H]1[C@@H](CN2CCCCC2)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C14H21N3O5/c18-10-4-7-17(14(21)15-10)13-12(20)11(19)9(22-13)8-16-5-2-1-3-6-16/h4,7,9,11-13,19-20H,1-3,5-6,8H2,(H,15,18,21)/t9-,11-,12-,13-/m1/s1
Affinity DataKi:  1.72E+5nMAssay Description:Inhibition of bovine pancreatic RNase A by spectrophotometric methodMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50292720(5'-deoxy-5'-N-morpholinouridine | CHEMBL460902)
Show SMILES O[C@@H]1[C@@H](CN2CCOCC2)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C13H19N3O6/c17-9-1-2-16(13(20)14-9)12-11(19)10(18)8(22-12)7-15-3-5-21-6-4-15/h1-2,8,10-12,18-19H,3-7H2,(H,14,17,20)/t8-,10-,11-,12-/m1/s1
Affinity DataKi:  1.79E+5nMAssay Description:Inhibition of bovine pancreatic RNase A by spectrophotometric methodMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50342008(1-[2,5-Dideoxy-5-(4-carboxypiperidinyl)-beta-D-thr...)
Show SMILES Cc1cn([C@H]2C[C@@H](O)[C@@H](CN3CCC(CC3)C(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C16H23N3O6/c1-9-7-19(16(24)17-14(9)21)13-6-11(20)12(25-13)8-18-4-2-10(3-5-18)15(22)23/h7,10-13,20H,2-6,8H2,1H3,(H,22,23)(H,17,21,24)/t11-,12-,13-/m1/s1
Affinity DataKi:  1.83E+5nMAssay Description:Inhibition of bovine pancreatic RNase A using 2',3'-cCMP as a substrate by Dixon plot analysisMore data for this Ligand-Target Pair
TargetRibonuclease pancreatic(Bison bison (American bison))
Indian Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50438458(CHEMBL2414519)
Show SMILES Cc1cn([C@H]2C[C@H](NCC(O)=O)[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C12H17N3O6/c1-6-4-15(12(20)14-11(6)19)9-2-7(8(5-16)21-9)13-3-10(17)18/h4,7-9,13,16H,2-3,5H2,1H3,(H,17,18)(H,14,19,20)/t7-,8+,9+/m0/s1
Affinity DataKi:  1.86E+5nMAssay Description:Reversible competitive inhibition of bovine pancreatic RNase A using 2',3'-cCMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
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