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Report error Found 1613 Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 1'
TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM20877(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Affinity DataKi:  50nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50595439(CHEMBL5178665)
Affinity DataKi:  97nMAssay Description:Inhibition of recombinant human SGLT1 expressed in COS-7 cells assessed as inhibition of [14C]AMG uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataKi:  180nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422357(CHEMBL2303984)
Affinity DataKi:  560nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataKi:  708nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153313(3-Cyclohexyl-1-[2-hydroxy-4-methyl-6-(3,4,5-trihyd...)
Affinity DataKi:  1.08E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153312(1-[2-Hydroxy-4-methyl-6-(3,4,5-trihydroxy-6-hydrox...)
Affinity DataKi:  1.32E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153306(1-[2-Hydroxy-4-methyl-6-(3,4,5-trihydroxy-6-hydrox...)
Affinity DataKi:  1.38E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153302(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[2-hydroxy...)
Affinity DataKi:  1.46E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153301(3-(4-Ethoxy-phenyl)-1-[2-hydroxy-4-methyl-6-(3,4,5...)
Affinity DataKi:  1.57E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50087823(1-[2-(4,5-Dihydroxy-6-hydroxymethyl-tetrahydro-pyr...)
Affinity DataKi:  2.60E+3nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422353(CHEMBL2303988)
Affinity DataKi:  2.80E+3nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153292(1-[4-Fluoro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...)
Affinity DataKi:  3.69E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153293(1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...)
Affinity DataKi:  3.75E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422355(CHEMBL2303989)
Affinity DataKi:  3.80E+3nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153303(3-Furan-3-yl-1-[2-hydroxy-4-methyl-6-(3,4,5-trihyd...)
Affinity DataKi:  4.38E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50559516(GSK-189075 | GSK-189075A | GSK189075A | Remogliflo...)
Affinity DataKi:  4.52E+3nMAssay Description:Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153299(1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...)
Affinity DataKi:  4.64E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153296(1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...)
Affinity DataKi:  4.78E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422350(CHEMBL2303987)
Affinity DataKi:  5.30E+3nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153298(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[4-ethyl-2...)
Affinity DataKi:  6.28E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153305(1-[4-Ethyl-2-hydroxy-6-(3,4,5-trihydroxy-6-hydroxy...)
Affinity DataKi:  6.50E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422349(CHEMBL2303986)
Affinity DataKi:  7.00E+3nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50351429(CHEMBL450044)
Affinity DataKi:  7.54E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422348(CHEMBL2303985)
Affinity DataKi:  7.70E+3nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153294(3-(4-Ethoxy-phenyl)-1-[4-ethyl-2-hydroxy-6-(3,4,5-...)
Affinity DataKi:  8.39E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153307(1-[2-Hydroxy-4-isopropyl-6-(3,4,5-trihydroxy-6-hyd...)
Affinity DataKi:  8.59E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153308(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Affinity DataKi:  9.89E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153297(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Affinity DataKi:  1.35E+4nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50409197(CHEMBL2096900)
Affinity DataKi:  1.40E+4nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153309(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[2-hydroxy...)
Affinity DataKi:  1.61E+4nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153311(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Affinity DataKi:  1.62E+4nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422352(CHEMBL2303990)
Affinity DataKi:  2.16E+4nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422346(CHEMBL2303991)
Affinity DataKi:  2.31E+4nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153304(3-(4-Ethoxy-phenyl)-1-[2-hydroxy-4-isopropyl-6-(3,...)
Affinity DataKi:  3.31E+4nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422351(CHEMBL2303981)
Affinity DataKi:  4.00E+4nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153300(1-[2-Chloro-6-(3,4,5-trihydroxy-6-hydroxymethyl-te...)
Affinity DataKi: >4.50E+4nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153310(1-[2-Chloro-6-(3,4,5-trihydroxy-6-hydroxymethyl-te...)
Affinity DataKi: >4.50E+4nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422356(CHEMBL2303983)
Affinity DataKi:  4.50E+4nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50153295(1-[2-Chloro-6-(3,4,5-trihydroxy-6-hydroxymethyl-te...)
Affinity DataKi: >4.50E+4nMAssay Description:In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM23446(3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...)
Affinity DataKi:  8.60E+4nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422345(CHEMBL2303982)
Affinity DataKi:  9.31E+4nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422358(CHEMBL2303994)
Affinity DataKi:  9.43E+4nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422354(CHEMBL2303993)
Affinity DataKi:  1.16E+5nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50422347(CHEMBL2303992)
Affinity DataKi:  1.52E+5nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50409196(CHEMBL2029165)
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50242614((S)-1-((S)-2-((S)-2,5-diamino-5-oxopentanamido)-3-...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50242617(CHEMBL521026 | QSPac)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of human SGLT1 expressed in xenopus laevis oocyte assessed as inhibition of methyl-alpha-D-[14C]glucopyranoside uptake after 1 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50560402(LIK-066 | Licogliflozin | Lik066 | USRE49080, Exam...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM402285(US10011627, 1)
Affinity DataIC50:  0.580nMAssay Description:The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


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