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Report error Found 535 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 4 subunit alpha'
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141067(3-[4-(2,4-Difluoro-phenoxy)-phenyl]-pyrazole-1-car...)
Affinity DataKi:  25nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141062(3-[4-(4-Fluoro-phenoxy)-phenyl]-pyrazole-1-carboxy...)
Affinity DataKi:  31nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141070(3-[4-(4-Nitro-phenoxy)-phenyl]-pyrazole-1-carboxyl...)
Affinity DataKi:  31nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141072(3-(4-Phenoxy-phenyl)-pyrazole-1-carboxylic acid am...)
Affinity DataKi:  35nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141065(3-[4-(4-Fluoro-phenoxy)-phenyl]-pyrazole-1-carboxy...)
Affinity DataKi:  150nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141073((E)-2-(4-(4-fluorophenoxy)benzylidene)hydrazinecar...)
Affinity DataKi:  180nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141066(3-[4-(4-Fluoro-phenoxy)-phenyl]-1H-pyrazole | CHEM...)
Affinity DataKi:  200nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141064(3-(4-Phenoxy-phenyl)-1H-pyrazole | CHEMBL41864)
Affinity DataKi:  240nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141071(3-[4-(4-Fluoro-phenoxy)-phenyl]-pyrazole-1-carboxy...)
Affinity DataKi:  340nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141069(3-[4-(4-Fluoro-phenoxy)-phenyl]-1-methyl-1H-pyrazo...)
Affinity DataKi:  690nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Affinity DataKi:  1.70E+4nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50003655(Phenytoin)
Affinity DataKi:  2.40E+4nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50003659(5H-dibenzo[b,f]azepine-5-carboxamide | CARBAMAZEPI...)
Affinity DataKi:  5.20E+4nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50078831(3-Phenyl-1H-pyrazole | CHEMBL38876)
Affinity DataKi:  6.10E+4nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50141063(3-(4-Methoxy-phenyl)-1H-pyrazole | CHEMBL39210)
Affinity DataKi:  8.10E+4nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50118519(CHEMBL3617050)
Affinity DataIC50:  0.0620nMAssay Description:Inhibition of NaV1.4 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50595862(CHEMBL5189924)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50595859(CHEMBL5192731)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50:  2.40nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50595863(CHEMBL5184022)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190239(US9174999, Table 1, Compound 7)
Affinity DataIC50:  15nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50:  19nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190241(US9174999, 10)
Affinity DataIC50:  19nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50077469(CHEMBL3416888)
Affinity DataIC50:  20nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190238(US9174999, Table 1, Compound 6)
Affinity DataIC50:  22.5nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50450603(CHEMBL4159473)
Affinity DataIC50:  23nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50450609(CHEMBL4170712)
Affinity DataIC50:  23nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190234(US9174999, 8)
Affinity DataIC50:  26nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSodium channel protein type 4 subunit alpha [I757A](Rat)
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50:  30nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50:  30nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: <30nMAssay Description:Inhibition of voltage-gated Na channel 1.4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50595856(CHEMBL5205795)
Affinity DataIC50:  32nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50595857(CHEMBL5192925)
Affinity DataIC50:  33nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50450602(CHEMBL4167379)
Affinity DataIC50:  37nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50450610(CHEMBL4160074)
Affinity DataIC50:  39nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM60830(US9174999, 13)
Affinity DataIC50:  46nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50595858(CHEMBL5204844)
Affinity DataIC50:  51nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50450597(CHEMBL4160943)
Affinity DataIC50:  52nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50450580(CHEMBL4169884)
Affinity DataIC50:  53nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190237(US9174999, Table 1, Compound 5)
Affinity DataIC50:  55nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSodium channel protein type 4 subunit alpha(Rat)
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM50520482(CHEMBL4562161)
Affinity DataIC50:  69nMAssay Description:Inhibition of rat Nav1.4 expressed in HEK293 cells at -80 mV holding potential by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50164184(CHEMBL3798824)
Affinity DataIC50:  70nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50077805(CHEMBL3416931)
Affinity DataIC50:  70nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50450583(CHEMBL4174312)
Affinity DataIC50:  72nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50595861(CHEMBL5204544)
Affinity DataIC50:  75nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50:  79nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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