Compile Data Set for Download or QSAR
Report error Found 273 Enz. Inhib. hit(s) with Target = 'Thermolysin'
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50442256(CHEMBL2442111)
Affinity DataKd:  210nMAssay Description:Binding affinity to Bacillus thermoproteolyticus thermolysin at pH 7.5 after 15 mins by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50442257(CHEMBL2028192)
Affinity DataKd:  32nMAssay Description:Binding affinity to Bacillus thermoproteolyticus thermolysin at pH 7.5 after 15 mins by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50422014(CHEMBL319299)
Affinity DataKd:  74nMAssay Description:Binding affinity against ThermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50473782(CHEMBL91805)
Affinity DataKd:  0.0631nMAssay Description:Binding affinity against ThermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50129202((S)-2-Amino-4-methyl-pentanoic acid hydroxyamide |...)
Affinity DataKd:  1.91E+5nMAssay Description:Binding affinity against ThermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50038066(Val-Trp | (S)-2-((S)-2-Amino-3-methyl-butyrylamino...)
Affinity DataKd:  1.23E+3nMAssay Description:Binding affinity against ThermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50006112((P-Leu-NH2) (1-Carbamoyl-3-methyl-butyl)-phosphora...)
Affinity DataKd:  1.29E+3nMAssay Description:Binding affinity against ThermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50251742((S)-2-{(R)-2-[Hydroxy-((2R,3R,4R,5R,6S)-3,4,5-trih...)
Affinity DataKd:  28nMAssay Description:Binding affinity against ThermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50473789(Nitroanilide)
Affinity DataKd:  427nMAssay Description:Binding affinity against ThermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50292712(1beta-D-arabinofuranosyl-N4-lauroylcytosine | CHEM...)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50035249(N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-N'-hydroxy...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50035247(2-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-3-(1H...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50035246(2-(2-Hydroxycarbamoyl-4-methyl-pentanoylamino)-3-(...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50044226(1-hydroxy-1-phenylethyl-phosphinoylamino]-propiony...)
Affinity DataIC50: 7nMAssay Description:Inhibition of metallopeptidase thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50035239(N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-N'-hydroxy...)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50321113(3-Phenyl-2-(trifluoromethyl)quinazolin-4(3H)-one |...)
Affinity DataIC50: 11.5nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50251742((S)-2-{(R)-2-[Hydroxy-((2R,3R,4R,5R,6S)-3,4,5-trih...)
Affinity DataIC50: 33nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50035235(N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydrox...)
Affinity DataIC50: 64nMAssay Description:Compound was tested in vitro for inhibitory activity against thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article

TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056252((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 68nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056252((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 68nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50035235(N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydrox...)
Affinity DataIC50: 175nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50321123(cid_949175 | CHEMBL1163762 | 3-(Isopropylideneamin...)
Affinity DataIC50: 248nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056249((6S,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50: 600nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056249((6S,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50: 600nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50321122(2-Ethylquinazolin-4(3H)-one | CHEMBL1163173)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50024102(((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataIC50: 1.80E+3nMAssay Description:Tested for binding affinity against ThermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056248((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056250((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50035236(3-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-propi...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50035237(2-(2-Hydroxycarbamoylmethyl-3-methyl-butyrylamino)...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056247((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056247((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056251((6R,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056251((6R,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50038623(2-(2-Benzyl-3-mercapto-5-methyl-hexanoylamino)-pro...)
Affinity DataIC50: 4.00E+3nMAssay Description:Tested for binding affinity against ThermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50204382(2-(benzyloxyamino)-N-hydroxyhexanamide | CHEMBL228...)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056258((3R,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[10.3....)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056261((3R,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[11.3....)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056256((6R,9S)-9-Mercaptomethyl-8-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056256((6R,9S)-9-Mercaptomethyl-8-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50138798(CHEMBL3754100)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 15 mins followed by the addition of 75 uM Abz-Ala-Gly-leu-Ala-p-n...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50138798(CHEMBL3754100)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50138801(CHEMBL3753984)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 15 mins followed by the addition of 75 uM Abz-Ala-Gly-leu-Ala-p-n...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50138801(CHEMBL3753984)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056259((3S,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[11.3....)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50321112(3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one | ...)
Affinity DataIC50: 3.79E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056253((6S,9S)-9-Mercaptomethyl-8-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Jiangxi Science and Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50056253((6S,9S)-9-Mercaptomethyl-8-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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