Compile Data Set for Download or QSAR
Found 774 Enz. Inhib. hit(s) with Target = 'Thyroid hormone receptor alpha'
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063689(CHEMBL3397337)
Affinity DataKi:  0.350nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063687(CHEMBL3397339)
Affinity DataKi:  0.380nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063755(CHEMBL3397341)
Affinity DataKi:  0.510nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50036402(CHEMBL46882 | N-[3,5-dimethyl-4-(4'-hydroxy-3'-iso...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50304777(2-(4-(7-hydroxy-2,3-dihydro-1H-inden-4-yloxy)-3,5-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to thyroid receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50115668(3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phen...)
Affinity DataKi:  1.09nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063690(CHEMBL3397336)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50274809(3,5-Diiodo-4-(4'-hydroxy-3'-isopropylphenoxy)benzy...)
Affinity DataKi:  1.84nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063688(CHEMBL3397338)
Affinity DataKi:  2.10nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50304778(3-(3-chloro-4-(3-(cyclobutylmethylsulfonyl)-4-hydr...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to thyroid receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [125I]-T3 from human TRalpha expressed in insect cells after 16 to 48 hrs by gamma-countingMore data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataKi:  2.33nMAssay Description:Displacement of [125I]T3 from human recombinant thyroid harmone receptor alpha after 16 to 48 hrs by gamma-ray detectionMore data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50385111(CHEMBL2035881)
Affinity DataKi:  2.45nMAssay Description:Displacement of [125I]T3 from human recombinant thyroid harmone receptor alpha after 16 to 48 hrs by gamma-ray detectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063686(CHEMBL3397340)
Affinity DataKi:  2.80nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50304781(2-(4-(3-(4-fluorobenzyl)-4-hydroxyphenoxy)-3,5-dim...)
Affinity DataKi:  3nMAssay Description:Binding affinity to thyroid receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50274812(CHEMBL457528 | [3,5-Diiodo-4-(4'-hydroxy-3'-isopro...)
Affinity DataKi:  3.74nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM18869(2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...)
Affinity DataKi:  7.18nMAssay Description:Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM18869(2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...)
Affinity DataKi:  7.18nMAssay Description:Binding affinity to TRalpha1More data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063691(CHEMBL3397335)
Affinity DataKi:  7.70nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM18869(2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...)
Affinity DataKi:  7.79nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50304780(2-(3,5-dichloro-4-(3-(4-fluorobenzyl)-4-hydroxyphe...)
Affinity DataKi:  8nMAssay Description:Binding affinity to thyroid receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50036421((S)-2-Amino-3-{3,5-dibromo-4-[4-hydroxy-3-(6-oxo-1...)
Affinity DataKi:  8.70nMAssay Description:Displacement of [125I]-T3 from human TRalpha expressed in insect cells after 16 to 48 hrs by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50385105(CHEMBL2035874 | US10322118, Entry 8b)
Affinity DataKi:  9.60nMAssay Description:Displacement of [125I]T3 from human recombinant thyroid harmone receptor alpha after 16 to 48 hrs by gamma-ray detectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063754(CHEMBL3397342)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50274846(CHEMBL511862 | [3,5-Dibromo-4-(4'-hydroxy-3'-isopr...)
Affinity DataKi:  10.3nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063693(CHEMBL3397333)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50274810(3,5-Diiodo-4-(4'-hydroxy-3'-iodophenoxy)benzylphos...)
Affinity DataKi:  16nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063692(CHEMBL3397334)
Affinity DataKi:  16nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50274811(CHEMBL457527 | [3,5-Dibromo-4-(4'-hydroxy-3'-isopr...)
Affinity DataKi:  18.6nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50123049(2-(3,5-dichloro-4-(4-hydroxy-3-(piperidine-1-carbo...)
Affinity DataKi:  20nMAssay Description:Binding affinity to thyroid receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50385101(CHEMBL2035876)
Affinity DataKi:  24.4nMAssay Description:Displacement of [125I]T3 from human recombinant thyroid harmone receptor alpha after 16 to 48 hrs by gamma-ray detectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50275291(CHEMBL485758 | [4-(4'-Hydroxy-3'-isopropylbenzyl)-...)
Affinity DataKi:  28.4nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50275257(CHEMBL448595 | [3,5-Dimethyl-4-(3'-sec-butyl-4'-hy...)
Affinity DataKi:  30.5nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50425407(CHEMBL2312281)
Affinity DataKi:  31nMAssay Description:Displacement of [125I]-T3 from human TRalpha expressed in insect cells after 16 to 48 hrs by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063751(CHEMBL3397344)
Affinity DataKi:  32nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50242403((3,5-dimethyl-4-(4-hydroxy-3-isopropylbenzyl)pheno...)
Affinity DataKi:  35.2nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50242403((3,5-dimethyl-4-(4-hydroxy-3-isopropylbenzyl)pheno...)
Affinity DataKi:  35.2nMAssay Description:Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063752(CHEMBL3397343)
Affinity DataKi:  37nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50036399(Axitirome | CHEMBL159682 | N-(4-{3-[(4-Fluoro-phen...)
Affinity DataKi:  40nMAssay Description:Displacement of [125I]-T3 from human TRalpha expressed in insect cells after 16 to 48 hrs by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50275295(2-[3,5-Dibromo-4-(4'-hydroxy-3'-isopropylphenoxy)p...)
Affinity DataKi:  42.1nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063750(CHEMBL3397345)
Affinity DataKi:  47nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50275228(CHEMBL485928 | [3,5-Dimethyl-4-(3'-ethyl-4'-hydrox...)
Affinity DataKi:  61.6nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50385109(CHEMBL2035879)
Affinity DataKi:  69.3nMAssay Description:Displacement of [125I]T3 from human recombinant thyroid harmone receptor alpha after 16 to 48 hrs by gamma-ray detectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50063695(CHEMBL3397346)
Affinity DataKi:  90nMAssay Description:Displacement of [125I]-L-3,5,3'-triiodothyronine from human TRalpha expressed in human Hela cell lysate measured after overnight incubation by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50425406(CHEMBL2312262)
Affinity DataKi:  92nMAssay Description:Displacement of [125I]-T3 from human TRalpha expressed in insect cells after 16 to 48 hrs by gamma-countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50304779(2-(3,5-dichloro-4-(4-hydroxy-3-(1,2,3,4-tetrahydro...)
Affinity DataKi:  126nMAssay Description:Binding affinity to thyroid receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50385102(CHEMBL2035882)
Affinity DataKi:  127nMAssay Description:Displacement of [125I]T3 from human recombinant thyroid harmone receptor alpha after 16 to 48 hrs by gamma-ray detectionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics Inc

Curated by ChEMBL
LigandPNGBDBM50275005(CHEMBL458784 | [4-(4'-Hydroxy-3'-isopropylphenoxy)...)
Affinity DataKi:  143nMAssay Description:Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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