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Report error Found 3643 Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily A member 1'
LigandPNGBDBM452629(7-bromo-5-methyl-3-[[3- [rac-(3R,5R)-5-(4- chlorop...)
Affinity DataIC50:  0.300nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM611197((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[3-[5...)
Affinity DataIC50:  0.380nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM611196((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[3-[6...)
Affinity DataIC50:  0.410nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM452561(5-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  0.420nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM611264((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[3-[4...)
Affinity DataIC50:  0.480nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM611236((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[2-[4...)
Affinity DataIC50:  0.610nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM611235((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[2-[4...)
Affinity DataIC50:  0.610nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM452526(2-amino-3-((3-((3R,5R)- 5-(4- chlorophenyl)tetrahy...)
Affinity DataIC50:  0.660nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM611331((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[6-[6...)
Affinity DataIC50:  0.660nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM452576(3-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  0.730nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM611205((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[2-[4...)
Affinity DataIC50:  0.760nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM452570(3-((3-((3R,5R)-5-(4- chlorophenyl)tetra- hydrofura...)
Affinity DataIC50:  0.800nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM452629(7-bromo-5-methyl-3-[[3- [rac-(3R,5R)-5-(4- chlorop...)
Affinity DataIC50:  0.800nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM611240((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[2-[6...)
Affinity DataIC50:  0.830nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM611265((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[3-[4...)
Affinity DataIC50:  0.830nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM611198((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[6-[4...)
Affinity DataIC50:  0.840nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  0.880nMAssay Description:The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM611330((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[4-[5...)
Affinity DataIC50:  0.880nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM611245((2S)-1-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[2-[2...)
Affinity DataIC50:  0.970nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361656(US10221177, Compound 19)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361663(US10221177, Compound 26)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361665(US10221177, Compound 28)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361666(US10221177, Compound 29)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361670(US10221177, Compound 33)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361671(US10221177, Compound 34)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM50193602(CHEMBL3907685)
Affinity DataIC50:  1nMAssay Description:Inhibition of cinnamaldehyde-activated full length human TRPA1 channel expressed in 293T-Rex cells monitored at 5 sec interval by manual patch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM611095((2S)-N-[[3-[(4-cyanophenyl) methoxy]phenyl]methyl]...)
Affinity DataIC50:  1nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361868(US10221177, Compound 241)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361872(US10221177, Compound 246)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361878(US10221177, Compound 252)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361888(US10221177, Compound 262)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361894(US10221177, Compound 268)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361792(US10221177, Compound 157)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361717(US10221177, Compound 80)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361736(US10221177, Compound 99)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361744(US10221177, Compound 107 | US10221177, Compound 10...)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361744(US10221177, Compound 107 | US10221177, Compound 10...)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361747(US10221177, Compound 110)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361749(US10221177, Compound 112)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361752(US10221177, Compound 115)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361758(US10221177, Compound 121)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361759(US10221177, Compound 122)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361761(US10221177, Compound 124)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361762(US10221177, Compound 125)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361763(US10221177, Compound 126)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361651(US10221177, Compound 14 | US10221177, Compound 270)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM361655(US10221177, Compound 18)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM437915((2S)-3-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[5-fl...)
Affinity DataIC50:  1.08nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM437925((2S)-3-(4- fluorophenyl)sulfonyl-N-[[2- (trifluoro...)
Affinity DataIC50:  1.18nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM611192((2S)-1-(benzofuran-2-ylsulfonyl)- N-[[3-[5-(triflu...)
Affinity DataIC50:  1.20nMAssay Description:The test substance was dissolved in dimethyl sulfoxide and serially diluted with an assay buffer containing 0.1% bovine serum albumin (1×HBSS, 20 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

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