Compile Data Set for Download or QSAR
Found 2843 Enz. Inhib. hit(s) with Target = 'Vasopressin V1a receptor'
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50221813(CHEMBL394602 | HO-LVA)
Show SMILES CN([C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CC[C@@H](C1)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)C(=O)Cc1ccc(O)cc1
Show InChI InChI=1S/C53H74N16O12/c1-68(44(74)27-32-13-17-35(71)18-14-32)41(26-31-11-15-34(70)16-12-31)50(80)67-39(25-30-7-3-2-4-8-30)48(78)64-37(19-20-42(54)72)47(77)66-40(28-43(55)73)49(79)65-38(10-6-23-62-53(59)60)51(81)69-24-21-33(29-69)46(76)63-36(45(56)75)9-5-22-61-52(57)58/h2-4,7-8,11-18,33,36-41,70-71H,5-6,9-10,19-29H2,1H3,(H2,54,72)(H2,55,73)(H2,56,75)(H,63,76)(H,64,78)(H,65,79)(H,66,77)(H,67,80)(H4,57,58,61)(H4,59,60,62)/t33-,36-,37-,38-,39-,40-,41+/m0/s1
Affinity DataKi:  0.0320nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50221813(CHEMBL394602 | HO-LVA)
Show SMILES CN([C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CC[C@@H](C1)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)C(=O)Cc1ccc(O)cc1
Show InChI InChI=1S/C53H74N16O12/c1-68(44(74)27-32-13-17-35(71)18-14-32)41(26-31-11-15-34(70)16-12-31)50(80)67-39(25-30-7-3-2-4-8-30)48(78)64-37(19-20-42(54)72)47(77)66-40(28-43(55)73)49(79)65-38(10-6-23-62-53(59)60)51(81)69-24-21-33(29-69)46(76)63-36(45(56)75)9-5-22-61-52(57)58/h2-4,7-8,11-18,33,36-41,70-71H,5-6,9-10,19-29H2,1H3,(H2,54,72)(H2,55,73)(H2,56,75)(H,63,76)(H,64,78)(H,65,79)(H,66,77)(H,67,80)(H4,57,58,61)(H4,59,60,62)/t33-,36-,37-,38-,39-,40-,41+/m0/s1
Affinity DataKi:  0.0360nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50418929(CHEMBL1807272)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(CCCC1)c1ccc(F)cc1
Show InChI InChI=1S/C29H37ClFN3O2/c1-34(2)25-15-13-24(14-16-25)32-27(35)26(19-20-5-9-22(30)10-6-20)33-28(36)29(17-3-4-18-29)21-7-11-23(31)12-8-21/h5-12,24-26H,3-4,13-19H2,1-2H3,(H,32,35)(H,33,36)/t24-,25-,26-/m1/s1
Affinity DataKi:  0.0372nMAssay Description:Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50418907(CHEMBL1807267)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H33Cl2N3O2/c1-32(2)23-13-11-22(12-14-23)30-25(33)24(17-18-3-7-20(28)8-4-18)31-26(34)27(15-16-27)19-5-9-21(29)10-6-19/h3-10,22-24H,11-17H2,1-2H3,(H,30,33)(H,31,34)/t22-,23-,24-/m1/s1
Affinity DataKi:  0.0398nMAssay Description:Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50319772((2'-methylbiphenyl-4-yl)((1S,5R)-1,3,3-trimethyl-6...)
Show SMILES Cc1ccccc1-c1ccc(cc1)C(=O)N1C[C@]2(C)C[C@H]1CC(C)(C)C2
Show InChI InChI=1S/C24H29NO/c1-17-7-5-6-8-21(17)18-9-11-19(12-10-18)22(26)25-16-24(4)14-20(25)13-23(2,3)15-24/h5-12,20H,13-16H2,1-4H3/t20-,24-/m1/s1
Affinity DataKi:  0.0500nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50319776((2,2'-dimethylbiphenyl-4-yl)((1S,5R)-1,3,3-trimeth...)
Show SMILES Cc1ccccc1-c1ccc(cc1C)C(=O)N1C[C@]2(C)C[C@H]1CC(C)(C)C2
Show InChI InChI=1S/C25H31NO/c1-17-8-6-7-9-21(17)22-11-10-19(12-18(22)2)23(27)26-16-25(5)14-20(26)13-24(3,4)15-25/h6-12,20H,13-16H2,1-5H3/t20-,25-/m1/s1
Affinity DataKi:  0.0600nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50075724(4HOPh(CH2)2CO-DTyr(Me)-Phe-Gln-Asn-Arg-Pro-Lys(5C-...)
Show SMILES CN(C)c1ccc2c(Oc3cc(ccc3C22OC(=O)c3cc(ccc23)C(=O)N([C@@H](CCCCN)C(N)=O)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)N(C)C(=O)CCc2ccc(O)cc2)N(C)C)c1
Show InChI InChI=1S/C79H96N16O16/c1-91(2)49-24-31-55-64(42-49)110-65-43-50(92(3)4)25-32-56(65)79(55)54-30-23-48(41-53(54)77(109)111-79)74(106)95(61(69(83)101)16-9-10-36-80)76(108)62-17-12-38-94(62)75(107)58(15-11-37-86-78(84)85)88-72(104)60(44-67(82)99)89-70(102)57(33-34-66(81)98)87-71(103)59(39-46-13-7-6-8-14-46)90-73(105)63(40-47-20-28-52(97)29-21-47)93(5)68(100)35-22-45-18-26-51(96)27-19-45/h6-8,13-14,18-21,23-32,41-43,57-63,96-97H,9-12,15-17,22,33-40,44,80H2,1-5H3,(H2,81,98)(H2,82,99)(H2,83,101)(H,87,103)(H,88,104)(H,89,102)(H,90,105)(H4,84,85,86)/t57-,58-,59-,60-,61-,62-,63+/m0/s1
Affinity DataKi:  0.0700nMAssay Description:Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50075720((HO-LVA23)2-{2-[3-(4-Hydroxy-phenyl)-2-(methyl-4-H...)
Show SMILES CN([C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)C(=O)Cc1ccc(O)cc1
Show InChI InChI=1S/C53H74N16O12/c1-68(44(74)28-32-15-19-34(71)20-16-32)41(27-31-13-17-33(70)18-14-31)50(80)67-38(26-30-8-3-2-4-9-30)47(77)64-36(21-22-42(54)72)46(76)66-39(29-43(55)73)48(78)65-37(11-6-24-62-53(59)60)51(81)69-25-7-12-40(69)49(79)63-35(45(56)75)10-5-23-61-52(57)58/h2-4,8-9,13-20,35-41,70-71H,5-7,10-12,21-29H2,1H3,(H2,54,72)(H2,55,73)(H2,56,75)(H,63,79)(H,64,77)(H,65,78)(H,66,76)(H,67,80)(H4,57,58,61)(H4,59,60,62)/t35-,36-,37-,38-,39-,40-,41+/m0/s1
Affinity DataKi:  0.0800nMAssay Description:Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50221815(4-({[(6-{N-[(1S)-5-amino-1-carbamoylpentyl]-1-[(3S...)
Show SMILES CC1CC(C)(C)N=C2C1CC1=C(c3cc4C(C)CC(C)(C)Nc4c(c3OC1C2S([O-])(=O)=O)S([O-])(=O)=O)c1c(Cl)c(SCC(=O)NCCCCCC(=O)N([C@@H](CCCCN)C(N)=O)C(=O)[C@H]2CCN(C2)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)N(C)C(=O)CCc2ccc(O)cc2)c(Cl)c(Cl)c1C([O-])=O
Show InChI InChI=1S/C94H122Cl3N17O23S3/c1-48-44-93(3,4)110-77-56(48)41-58-71(59-42-57-49(2)45-94(5,6)111-78(57)83(140(134,135)136)80(59)137-79(58)82(77)139(131,132)133)72-73(91(129)130)74(95)76(97)81(75(72)96)138-47-68(119)104-36-15-9-12-21-70(121)114(64(84(101)122)20-13-14-35-98)89(127)53-34-38-113(46-53)90(128)61(19-16-37-105-92(102)103)107-87(125)63(43-67(100)118)108-85(123)60(31-32-66(99)117)106-86(124)62(39-51-17-10-8-11-18-51)109-88(126)65(40-52-24-29-55(116)30-25-52)112(7)69(120)33-26-50-22-27-54(115)28-23-50/h8,10-11,17-18,22-25,27-30,41,48-49,53,57,60-65,80,83,110,115-116H,9,12-16,19-21,26,31-40,42-47,98H2,1-7H3,(H2,99,117)(H2,100,118)(H2,101,122)(H,104,119)(H,106,124)(H,107,125)(H,108,123)(H,109,126)(H,129,130)(H4,102,103,105)(H,131,132,133)(H,134,135,136)/p-3/t48?,49?,53-,57?,60-,61-,62-,63-,64-,65+,80?,83?/m0/s1
Affinity DataKi:  0.0900nMAssay Description:Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50418909(CHEMBL1807270)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H35Cl2N3O2/c1-33(2)24-14-12-23(13-15-24)31-26(34)25(18-19-4-8-21(29)9-5-19)32-27(35)28(16-3-17-28)20-6-10-22(30)11-7-20/h4-11,23-25H,3,12-18H2,1-2H3,(H,31,34)(H,32,35)/t23-,24-,25-/m1/s1
Affinity DataKi:  0.0955nMAssay Description:Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50319799((4-(1H-indol-3-yl)-3-methoxyphenyl)((1S,5R)-1,3,3-...)
Show SMILES COc1cc(ccc1-c1c[nH]c2ccccc12)C(=O)N1C[C@]2(C)C[C@H]1CC(C)(C)C2
Show InChI InChI=1S/C26H30N2O2/c1-25(2)12-18-13-26(3,15-25)16-28(18)24(29)17-9-10-20(23(11-17)30-4)21-14-27-22-8-6-5-7-19(21)22/h5-11,14,18,27H,12-13,15-16H2,1-4H3/t18-,26-/m1/s1
Affinity DataKi:  0.100nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50108501(2-Methyl-furan-3-carboxylic acid (4-{5-[2-(4-dimet...)
Show SMILES CN(C)C1CCN(CC1)C(=O)\C=C1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(NC(=O)c2ccoc2C)cc1
Show InChI InChI=1S/C32H34F2N4O4/c1-21-25(14-19-42-21)30(40)35-23-10-8-22(9-11-23)31(41)38-18-15-32(33,34)27(26-6-4-5-7-28(26)38)20-29(39)37-16-12-24(13-17-37)36(2)3/h4-11,14,19-20,24H,12-13,15-18H2,1-3H3,(H,35,40)/b27-20+
Affinity DataKi:  0.102nMAssay Description:Evaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligandMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50038601(4-N3-C6H4CH2CH2CO-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Ar...)
Show SMILES CN([C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)CCc1ccc(cc1)N=[N+]=[N-]
Show InChI InChI=1S/C63H84N20O13/c1-82(53(88)28-19-36-13-20-40(21-14-36)80-81-71)50(34-39-17-24-42(85)25-18-39)60(95)79-47(33-37-8-3-2-4-9-37)57(92)74-44(26-27-51(64)86)56(91)78-48(35-52(65)87)58(93)76-45(11-6-30-73-63(69)70)61(96)83-31-7-12-49(83)59(94)75-43(10-5-29-72-62(67)68)55(90)77-46(54(66)89)32-38-15-22-41(84)23-16-38/h2-4,8-9,13-18,20-25,43-50,84-85H,5-7,10-12,19,26-35H2,1H3,(H2,64,86)(H2,65,87)(H2,66,89)(H,74,92)(H,75,94)(H,76,93)(H,77,90)(H,78,91)(H,79,95)(H4,67,68,72)(H4,69,70,73)/t43-,44-,45-,46-,47-,48-,49-,50-/m0/s1
Affinity DataKi:  0.110nMAssay Description:Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subty...More data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50038602(4-N3-C6H4CH2CO-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-T...)
Show SMILES CN([C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)Cc1ccc(cc1)N=[N+]=[N-]
Show InChI InChI=1S/C62H82N20O13/c1-81(52(87)33-38-13-19-39(20-14-38)79-80-70)49(32-37-17-23-41(84)24-18-37)59(94)78-46(31-35-8-3-2-4-9-35)56(91)73-43(25-26-50(63)85)55(90)77-47(34-51(64)86)57(92)75-44(11-6-28-72-62(68)69)60(95)82-29-7-12-48(82)58(93)74-42(10-5-27-71-61(66)67)54(89)76-45(53(65)88)30-36-15-21-40(83)22-16-36/h2-4,8-9,13-24,42-49,83-84H,5-7,10-12,25-34H2,1H3,(H2,63,85)(H2,64,86)(H2,65,88)(H,73,91)(H,74,93)(H,75,92)(H,76,89)(H,77,90)(H,78,94)(H4,66,67,71)(H4,68,69,72)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
Affinity DataKi:  0.120nMAssay Description:Inhibition constant for V1a receptor of rat liver membraneMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50038603(3-N3-C6H4CH2CH2CO-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Ar...)
Show SMILES CN([C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)CCc1cccc(c1)N=[N+]=[N-]
Show InChI InChI=1S/C63H84N20O13/c1-82(53(88)27-20-37-11-5-12-40(31-37)80-81-71)50(34-39-18-23-42(85)24-19-39)60(95)79-47(33-36-9-3-2-4-10-36)57(92)74-44(25-26-51(64)86)56(91)78-48(35-52(65)87)58(93)76-45(14-7-29-73-63(69)70)61(96)83-30-8-15-49(83)59(94)75-43(13-6-28-72-62(67)68)55(90)77-46(54(66)89)32-38-16-21-41(84)22-17-38/h2-5,9-12,16-19,21-24,31,43-50,84-85H,6-8,13-15,20,25-30,32-35H2,1H3,(H2,64,86)(H2,65,87)(H2,66,89)(H,74,92)(H,75,94)(H,76,93)(H,77,90)(H,78,91)(H,79,95)(H4,67,68,72)(H4,69,70,73)/t43-,44-,45-,46-,47-,48-,49-,50-/m0/s1
Affinity DataKi:  0.130nMAssay Description:Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subty...More data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50108498(Biphenyl-2-carboxylic acid (4-{5-[2-(4-dimethylami...)
Show SMILES CN(C)C1CCN(CC1)C(=O)\C=C1\c2ccccc2N(CCC1(F)F)C(=O)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1
Show InChI InChI=1S/C39H38F2N4O3/c1-43(2)30-20-23-44(24-21-30)36(46)26-34-33-14-8-9-15-35(33)45(25-22-39(34,40)41)38(48)28-16-18-29(19-17-28)42-37(47)32-13-7-6-12-31(32)27-10-4-3-5-11-27/h3-19,26,30H,20-25H2,1-2H3,(H,42,47)/b34-26-
Affinity DataKi:  0.160nMAssay Description:Binding affinity at Vasopressin V1a receptor, performed using [3H]-AVP on rat liverMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50038603(3-N3-C6H4CH2CH2CO-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Ar...)
Show SMILES CN([C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)CCc1cccc(c1)N=[N+]=[N-]
Show InChI InChI=1S/C63H84N20O13/c1-82(53(88)27-20-37-11-5-12-40(31-37)80-81-71)50(34-39-18-23-42(85)24-19-39)60(95)79-47(33-36-9-3-2-4-10-36)57(92)74-44(25-26-51(64)86)56(91)78-48(35-52(65)87)58(93)76-45(14-7-29-73-63(69)70)61(96)83-30-8-15-49(83)59(94)75-43(13-6-28-72-62(67)68)55(90)77-46(54(66)89)32-38-16-21-41(84)22-17-38/h2-5,9-12,16-19,21-24,31,43-50,84-85H,6-8,13-15,20,25-30,32-35H2,1H3,(H2,64,86)(H2,65,87)(H2,66,89)(H,74,92)(H,75,94)(H,76,93)(H,77,90)(H,78,91)(H,79,95)(H4,67,68,72)(H4,69,70,73)/t43-,44-,45-,46-,47-,48-,49-,50-/m0/s1
Affinity DataKi:  0.160nMAssay Description:Inhibition constant for V1a receptor of rat liver membraneMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50075725(4HOPh(CH2)2CO-DTyr(Me)-Phe-Gln-Asn-Arg-Pro-Lys(6C-...)
Show SMILES CN(C)c1ccc2c(Oc3cc(ccc3C22OC(=O)c3ccc(cc23)C(=O)N([C@@H](CCCCN)C(N)=O)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)N(C)C(=O)CCc2ccc(O)cc2)N(C)C)c1
Show InChI InChI=1S/C79H96N16O16/c1-91(2)49-24-31-54-64(42-49)110-65-43-50(92(3)4)25-32-55(65)79(54)56-41-48(23-30-53(56)77(109)111-79)74(106)95(61(69(83)101)16-9-10-36-80)76(108)62-17-12-38-94(62)75(107)58(15-11-37-86-78(84)85)88-72(104)60(44-67(82)99)89-70(102)57(33-34-66(81)98)87-71(103)59(39-46-13-7-6-8-14-46)90-73(105)63(40-47-20-28-52(97)29-21-47)93(5)68(100)35-22-45-18-26-51(96)27-19-45/h6-8,13-14,18-21,23-32,41-43,57-63,96-97H,9-12,15-17,22,33-40,44,80H2,1-5H3,(H2,81,98)(H2,82,99)(H2,83,101)(H,87,103)(H,88,104)(H,89,102)(H,90,105)(H4,84,85,86)/t57-,58-,59-,60-,61-,62-,63+/m0/s1
Affinity DataKi:  0.170nMAssay Description:Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50075722(4HOPh(CH2)2CO-DTyr(Me)-Phe-Gln-Asn-Arg-Pro-Lys(5C-...)
Show SMILES CN([C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N([C@@H](CCCCN)C(N)=O)C(=O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc12)C(=O)CCc1ccc(O)cc1
Show InChI InChI=1S/C75H86N14O18/c1-87(64(96)31-18-41-14-20-45(90)21-15-41)59(36-43-16-22-46(91)23-17-43)69(101)86-55(35-42-9-3-2-4-10-42)67(99)83-53(29-30-62(77)94)66(98)85-56(40-63(78)95)68(100)84-54(11-7-33-82-74(80)81)71(103)88-34-8-13-58(88)72(104)89(57(65(79)97)12-5-6-32-76)70(102)44-19-26-50-49(37-44)73(105)107-75(50)51-27-24-47(92)38-60(51)106-61-39-48(93)25-28-52(61)75/h2-4,9-10,14-17,19-28,37-39,53-59,90-93H,5-8,11-13,18,29-36,40,76H2,1H3,(H2,77,94)(H2,78,95)(H2,79,97)(H,83,99)(H,84,100)(H,85,98)(H,86,101)(H4,80,81,82)/t53-,54-,55-,56-,57-,58-,59+/m0/s1
Affinity DataKi:  0.170nMAssay Description:Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50038599(4-N3-C6H4CH2CH2CH2CO-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro...)
Show SMILES CN([C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)CCCc1ccc(cc1)N=[N+]=[N-]
Show InChI InChI=1S/C64H86N20O13/c1-83(54(89)15-5-11-37-16-22-41(23-17-37)81-82-72)51(35-40-20-26-43(86)27-21-40)61(96)80-48(34-38-9-3-2-4-10-38)58(93)75-45(28-29-52(65)87)57(92)79-49(36-53(66)88)59(94)77-46(13-7-31-74-64(70)71)62(97)84-32-8-14-50(84)60(95)76-44(12-6-30-73-63(68)69)56(91)78-47(55(67)90)33-39-18-24-42(85)25-19-39/h2-4,9-10,16-27,44-51,85-86H,5-8,11-15,28-36H2,1H3,(H2,65,87)(H2,66,88)(H2,67,90)(H,75,93)(H,76,95)(H,77,94)(H,78,91)(H,79,92)(H,80,96)(H4,68,69,73)(H4,70,71,74)/t44-,45-,46-,47-,48-,49-,50-,51-/m0/s1
Affinity DataKi:  0.180nMAssay Description:Inhibition constant for V1a receptor of rat liver membraneMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50166224(CHEMBL410567 | Vasopressin Analogue)
Show SMILES COc1ccc(C[C@@H](NC(=O)CCCc2ccc(cc2)N=[N+]=[N-])C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2ccc(O)c(I)c2)C(N)=O)cc1
Show InChI InChI=1S/C64H85IN20O13/c1-98-41-23-18-38(19-24-41)33-47(76-54(89)15-5-11-36-16-21-40(22-17-36)83-84-73)58(93)81-48(32-37-9-3-2-4-10-37)59(94)77-44(25-27-52(66)87)57(92)82-49(35-53(67)88)60(95)79-45(13-7-29-75-64(71)72)62(97)85-30-8-14-50(85)61(96)78-43(12-6-28-74-63(69)70)56(91)80-46(55(68)90)34-39-20-26-51(86)42(65)31-39/h2-4,9-10,16-24,26,31,43-50,86H,5-8,11-15,25,27-30,32-35H2,1H3,(H2,66,87)(H2,67,88)(H2,68,90)(H,76,89)(H,77,94)(H,78,96)(H,79,95)(H,80,91)(H,81,93)(H,82,92)(H4,69,70,74)(H4,71,72,75)/t43-,44-,45-,46-,47+,48-,49-,50+/m0/s1
Affinity DataKi:  0.180nMAssay Description:Binding affinity against rat vasopressin V1a receptorMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50418906(CHEMBL1807266)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C25H31Cl2N3O2/c1-30(2)22-13-11-21(12-14-22)28-25(32)23(15-17-3-7-19(26)8-4-17)29-24(31)16-18-5-9-20(27)10-6-18/h3-10,21-23H,11-16H2,1-2H3,(H,28,32)(H,29,31)/t21-,22-,23-/m1/s1
Affinity DataKi:  0.182nMAssay Description:Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50114031((2S)-1-[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)N1[C@@H](C(=O)N2CCC[C@H]2C(N)=O)[C@](O)(c2cc(Cl)ccc12)c1ccccc1Cl
Show InChI InChI=1S/C28H27Cl2N3O7S/c1-39-23-12-10-17(15-24(23)40-2)41(37,38)33-21-11-9-16(29)14-19(21)28(36,18-6-3-4-7-20(18)30)25(33)27(35)32-13-5-8-22(32)26(31)34/h3-4,6-7,9-12,14-15,22,25,36H,5,8,13H2,1-2H3,(H2,31,34)/t22-,25-,28+/m0/s1
Affinity DataKi:  0.190nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50202918((S)-N-(2-fluoro-3-(trifluoromethyl)benzyl)-5-(4-cy...)
Show SMILES Fc1c(CNC(=O)[C@H](CCC(=O)N2CCN(CC2)C2CCCCC2)N2[C@H](\C=C\c3ccccc3)[C@H](N3[C@H](COC3=O)c3ccccc3)C2=O)cccc1C(F)(F)F
Show InChI InChI=1S/C43H47F4N5O5/c44-38-31(15-10-18-33(38)43(45,46)47)27-48-40(54)35(21-22-37(53)50-25-23-49(24-26-50)32-16-8-3-9-17-32)51-34(20-19-29-11-4-1-5-12-29)39(41(51)55)52-36(28-57-42(52)56)30-13-6-2-7-14-30/h1-2,4-7,10-15,18-20,32,34-36,39H,3,8-9,16-17,21-28H2,(H,48,54)/b20-19+/t34-,35+,36-,39+/m1/s1
Affinity DataKi:  0.200nMAssay Description:Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50038601(4-N3-C6H4CH2CH2CO-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Ar...)
Show SMILES CN([C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)CCc1ccc(cc1)N=[N+]=[N-]
Show InChI InChI=1S/C63H84N20O13/c1-82(53(88)28-19-36-13-20-40(21-14-36)80-81-71)50(34-39-17-24-42(85)25-18-39)60(95)79-47(33-37-8-3-2-4-9-37)57(92)74-44(26-27-51(64)86)56(91)78-48(35-52(65)87)58(93)76-45(11-6-30-73-63(69)70)61(96)83-31-7-12-49(83)59(94)75-43(10-5-29-72-62(67)68)55(90)77-46(54(66)89)32-38-15-22-41(84)23-16-38/h2-4,8-9,13-18,20-25,43-50,84-85H,5-7,10-12,19,26-35H2,1H3,(H2,64,86)(H2,65,87)(H2,66,89)(H,74,92)(H,75,94)(H,76,93)(H,77,90)(H,78,91)(H,79,95)(H4,67,68,72)(H4,69,70,73)/t43-,44-,45-,46-,47-,48-,49-,50-/m0/s1
Affinity DataKi:  0.200nMAssay Description:Inhibition constant for V1a receptor of rat liver membraneMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50038602(4-N3-C6H4CH2CO-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-T...)
Show SMILES CN([C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)Cc1ccc(cc1)N=[N+]=[N-]
Show InChI InChI=1S/C62H82N20O13/c1-81(52(87)33-38-13-19-39(20-14-38)79-80-70)49(32-37-17-23-41(84)24-18-37)59(94)78-46(31-35-8-3-2-4-9-35)56(91)73-43(25-26-50(63)85)55(90)77-47(34-51(64)86)57(92)75-44(11-6-28-72-62(68)69)60(95)82-29-7-12-48(82)58(93)74-42(10-5-27-71-61(66)67)54(89)76-45(53(65)88)30-36-15-21-40(83)22-16-36/h2-4,8-9,13-24,42-49,83-84H,5-7,10-12,25-34H2,1H3,(H2,63,85)(H2,64,86)(H2,65,88)(H,73,91)(H,74,93)(H,75,92)(H,76,89)(H,77,90)(H,78,94)(H4,66,67,71)(H4,68,69,72)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
Affinity DataKi:  0.200nMAssay Description:Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subty...More data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50469544(CHEMBL4281963)
Show SMILES COc1ccc(C[C@@H](NC(=O)CCc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)cc1
Show InChI InChI=1S/C54H76N16O12/c1-82-35-20-15-33(16-21-35)29-39(64-45(74)24-17-31-13-18-34(71)19-14-31)48(77)68-40(28-32-8-3-2-4-9-32)49(78)66-37(22-23-43(55)72)47(76)69-41(30-44(56)73)50(79)67-38(11-6-26-63-54(60)61)52(81)70-27-7-12-42(70)51(80)65-36(46(57)75)10-5-25-62-53(58)59/h2-4,8-9,13-16,18-21,36-42,71H,5-7,10-12,17,22-30H2,1H3,(H2,55,72)(H2,56,73)(H2,57,75)(H,64,74)(H,65,80)(H,66,78)(H,67,79)(H,68,77)(H,69,76)(H4,58,59,62)(H4,60,61,63)/t36-,37-,38-,39+,40-,41-,42-/m0/s1
Affinity DataKi:  0.200nMAssay Description:Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50418914(CHEMBL1807281)
Show SMILES OC1CCCCC1NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C23H26Cl2N2O3/c24-17-9-5-15(6-10-17)13-20(23(30)27-19-3-1-2-4-21(19)28)26-22(29)14-16-7-11-18(25)12-8-16/h5-12,19-21,28H,1-4,13-14H2,(H,26,29)(H,27,30)/t19?,20-,21?/m1/s1
Affinity DataKi:  0.209nMAssay Description:Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50221813(CHEMBL394602 | HO-LVA)
Show SMILES CN([C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CC[C@@H](C1)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)C(=O)Cc1ccc(O)cc1
Show InChI InChI=1S/C53H74N16O12/c1-68(44(74)27-32-13-17-35(71)18-14-32)41(26-31-11-15-34(70)16-12-31)50(80)67-39(25-30-7-3-2-4-8-30)48(78)64-37(19-20-42(54)72)47(77)66-40(28-43(55)73)49(79)65-38(10-6-23-62-53(59)60)51(81)69-24-21-33(29-69)46(76)63-36(45(56)75)9-5-22-61-52(57)58/h2-4,7-8,11-18,33,36-41,70-71H,5-6,9-10,19-29H2,1H3,(H2,54,72)(H2,55,73)(H2,56,75)(H,63,76)(H,64,78)(H,65,79)(H,66,77)(H,67,80)(H4,57,58,61)(H4,59,60,62)/t33-,36-,37-,38-,39-,40-,41+/m0/s1
Affinity DataKi:  0.210nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranesMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50221813(CHEMBL394602 | HO-LVA)
Show SMILES CN([C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CC[C@@H](C1)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)C(=O)Cc1ccc(O)cc1
Show InChI InChI=1S/C53H74N16O12/c1-68(44(74)27-32-13-17-35(71)18-14-32)41(26-31-11-15-34(70)16-12-31)50(80)67-39(25-30-7-3-2-4-8-30)48(78)64-37(19-20-42(54)72)47(77)66-40(28-43(55)73)49(79)65-38(10-6-23-62-53(59)60)51(81)69-24-21-33(29-69)46(76)63-36(45(56)75)9-5-22-61-52(57)58/h2-4,7-8,11-18,33,36-41,70-71H,5-6,9-10,19-29H2,1H3,(H2,54,72)(H2,55,73)(H2,56,75)(H,63,76)(H,64,78)(H,65,79)(H,66,77)(H,67,80)(H4,57,58,61)(H4,59,60,62)/t33-,36-,37-,38-,39-,40-,41+/m0/s1
Affinity DataKi:  0.210nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50075728(4HOPh(CH2)2CO-DTyr(Me)-Phe-Gln-Asn-Arg-Pro-Lys(6C-...)
Show SMILES CN([C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N([C@@H](CCCCN)C(N)=O)C(=O)c1ccc2C(=O)OC3(c2c1)c1ccc(O)cc1Oc1cc(O)ccc31)C(=O)CCc1ccc(O)cc1
Show InChI InChI=1S/C75H86N14O18/c1-87(64(96)31-18-41-14-20-45(90)21-15-41)59(36-43-16-22-46(91)23-17-43)69(101)86-55(35-42-9-3-2-4-10-42)67(99)83-53(29-30-62(77)94)66(98)85-56(40-63(78)95)68(100)84-54(11-7-33-82-74(80)81)71(103)88-34-8-13-58(88)72(104)89(57(65(79)97)12-5-6-32-76)70(102)44-19-26-49-52(37-44)75(107-73(49)105)50-27-24-47(92)38-60(50)106-61-39-48(93)25-28-51(61)75/h2-4,9-10,14-17,19-28,37-39,53-59,90-93H,5-8,11-13,18,29-36,40,76H2,1H3,(H2,77,94)(H2,78,95)(H2,79,97)(H,83,99)(H,84,100)(H,85,98)(H,86,101)(H4,80,81,82)/t53-,54-,55-,56-,57-,58-,59+/m0/s1
Affinity DataKi:  0.230nMAssay Description:Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50418366(CHEMBL1774023)
Show SMILES Clc1ccc(C[C@@H](NC(=O)Cc2ccc(Cl)cc2)C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)cc1
Show InChI InChI=1S/C24H27Cl2N3O2/c25-17-5-1-15(2-6-17)11-22(29-23(30)12-16-3-7-18(26)8-4-16)24(31)28-21-13-19-9-10-20(14-21)27-19/h1-8,19-22,27H,9-14H2,(H,28,31)(H,29,30)/t19-,20+,21+,22-/m1/s1
Affinity DataKi:  0.234nMAssay Description:Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50418366(CHEMBL1774023)
Show SMILES Clc1ccc(C[C@@H](NC(=O)Cc2ccc(Cl)cc2)C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)cc1
Show InChI InChI=1S/C24H27Cl2N3O2/c25-17-5-1-15(2-6-17)11-22(29-23(30)12-16-3-7-18(26)8-4-16)24(31)28-21-13-19-9-10-20(14-21)27-19/h1-8,19-22,27H,9-14H2,(H,28,31)(H,29,30)/t19-,20+,21+,22-/m1/s1
Affinity DataKi:  0.234nMAssay Description:Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50038604(3-N3-C6H4CH2CO-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-T...)
Show SMILES CN([C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)Cc1cccc(c1)N=[N+]=[N-]
Show InChI InChI=1S/C62H82N20O13/c1-81(52(87)33-38-11-5-12-39(29-38)79-80-70)49(32-37-18-22-41(84)23-19-37)59(94)78-46(31-35-9-3-2-4-10-35)56(91)73-43(24-25-50(63)85)55(90)77-47(34-51(64)86)57(92)75-44(14-7-27-72-62(68)69)60(95)82-28-8-15-48(82)58(93)74-42(13-6-26-71-61(66)67)54(89)76-45(53(65)88)30-36-16-20-40(83)21-17-36/h2-5,9-12,16-23,29,42-49,83-84H,6-8,13-15,24-28,30-34H2,1H3,(H2,63,85)(H2,64,86)(H2,65,88)(H,73,91)(H,74,93)(H,75,92)(H,76,89)(H,77,90)(H,78,94)(H4,66,67,71)(H4,68,69,72)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
Affinity DataKi:  0.240nMAssay Description:Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subty...More data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50418905(CHEMBL1807273)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C27H33ClFN3O2/c1-32(2)23-13-11-22(12-14-23)30-25(33)24(17-18-3-7-20(28)8-4-18)31-26(34)27(15-16-27)19-5-9-21(29)10-6-19/h3-10,22-24H,11-17H2,1-2H3,(H,30,33)(H,31,34)/t22-,23-,24-/m1/s1
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM85095(CAS_151171 | CONIVAPTAN | NSC_151171 | YM087)
Show SMILES Cc1nc-2c(CCN(C(=O)c3ccc(NC(=O)c4ccccc4-c4ccccc4)cc3)c3ccccc-23)[nH]1
Show InChI InChI=1S/C32H26N4O2/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37)
Affinity DataKi:  0.240nMMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50418910(CHEMBL1807271)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(CCC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H35ClFN3O2/c1-33(2)24-14-12-23(13-15-24)31-26(34)25(18-19-4-8-21(29)9-5-19)32-27(35)28(16-3-17-28)20-6-10-22(30)11-7-20/h4-11,23-25H,3,12-18H2,1-2H3,(H,31,34)(H,32,35)/t23-,24-,25-/m1/s1
Affinity DataKi:  0.251nMAssay Description:Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50202900((S)-N-(3-(trifluoromethyl)benzyl)-5-(4-cyclohexylp...)
Show SMILES FC(F)(F)c1cccc(CNC(=O)[C@H](CCC(=O)N2CCN(CC2)C2CCCCC2)N2[C@H](\C=C\c3ccccc3)[C@H](N3[C@H](COC3=O)c3ccccc3)C2=O)c1
Show InChI InChI=1S/C43H48F3N5O5/c44-43(45,46)33-16-10-13-31(27-33)28-47-40(53)36(21-22-38(52)49-25-23-48(24-26-49)34-17-8-3-9-18-34)50-35(20-19-30-11-4-1-5-12-30)39(41(50)54)51-37(29-56-42(51)55)32-14-6-2-7-15-32/h1-2,4-7,10-16,19-20,27,34-37,39H,3,8-9,17-18,21-26,28-29H2,(H,47,53)/b20-19+/t35-,36+,37-,39+/m1/s1
Affinity DataKi:  0.270nMAssay Description:Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50221813(CHEMBL394602 | HO-LVA)
Show SMILES CN([C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CC[C@@H](C1)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)C(=O)Cc1ccc(O)cc1
Show InChI InChI=1S/C53H74N16O12/c1-68(44(74)27-32-13-17-35(71)18-14-32)41(26-31-11-15-34(70)16-12-31)50(80)67-39(25-30-7-3-2-4-8-30)48(78)64-37(19-20-42(54)72)47(77)66-40(28-43(55)73)49(79)65-38(10-6-23-62-53(59)60)51(81)69-24-21-33(29-69)46(76)63-36(45(56)75)9-5-22-61-52(57)58/h2-4,7-8,11-18,33,36-41,70-71H,5-6,9-10,19-29H2,1H3,(H2,54,72)(H2,55,73)(H2,56,75)(H,63,76)(H,64,78)(H,65,79)(H,66,77)(H,67,80)(H4,57,58,61)(H4,59,60,62)/t33-,36-,37-,38-,39-,40-,41+/m0/s1
Affinity DataKi:  0.280nMAssay Description:Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50202920(2(R)-[[4-(piperidin-1-yl)piperidin-1-yl]carbonylme...)
Show SMILES C[C@@H](NC(=O)[C@@H](CC(=O)N1CCC(CC1)N1CCCCC1)N1[C@H](\C=C\c2ccccc2)[C@H](N2[C@H](COC2=O)c2ccccc2)C1=O)c1ccccc1
Show InChI InChI=1S/C42H49N5O5/c1-30(32-16-8-3-9-17-32)43-40(49)36(28-38(48)45-26-22-34(23-27-45)44-24-12-5-13-25-44)46-35(21-20-31-14-6-2-7-15-31)39(41(46)50)47-37(29-52-42(47)51)33-18-10-4-11-19-33/h2-4,6-11,14-21,30,34-37,39H,5,12-13,22-29H2,1H3,(H,43,49)/b21-20+/t30-,35-,36-,37-,39+/m1/s1
Affinity DataKi:  0.300nMAssay Description:Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50583877(CHEMBL5070261)
Show SMILES OC1Cc2nnc([C@H]3CC[C@@H](CC3)Oc3ccccn3)n2-c2ccc(Cl)cc2C1
Show InChI InChI=1S/C22H23ClN4O2/c23-16-6-9-19-15(11-16)12-17(28)13-20-25-26-22(27(19)20)14-4-7-18(8-5-14)29-21-3-1-2-10-24-21/h1-3,6,9-11,14,17-18,28H,4-5,7-8,12-13H2/t14-,17?,18-
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50459408(CHEMBL3307200)
Show SMILES Cc1occc1C(=O)Nc1ccc(cc1)C(=O)N1CCC(F)(F)\C(=C/C(=O)N2CCC(CC2)N2CCCCC2)c2ccccc12
Show InChI InChI=1S/C35H38F2N4O4/c1-24-28(15-22-45-24)33(43)38-26-11-9-25(10-12-26)34(44)41-21-16-35(36,37)30(29-7-3-4-8-31(29)41)23-32(42)40-19-13-27(14-20-40)39-17-5-2-6-18-39/h3-4,7-12,15,22-23,27H,2,5-6,13-14,16-21H2,1H3,(H,38,43)/b30-23-
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-AVP from human V1A receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50583879(CHEMBL5070075)
Show SMILES O[C@H]1Cc2nnc([C@H]3CC[C@@H](CC3)Oc3ccccn3)n2-c2ccc(Cl)cc2C1
Show InChI InChI=1S/C22H23ClN4O2/c23-16-6-9-19-15(11-16)12-17(28)13-20-25-26-22(27(19)20)14-4-7-18(8-5-14)29-21-3-1-2-10-24-21/h1-3,6,9-11,14,17-18,28H,4-5,7-8,12-13H2/t14-,17-,18-/m1/s1
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50583878(CHEMBL5074709)
Show SMILES O[C@@H]1Cc2nnc([C@H]3CC[C@@H](CC3)Oc3ccccn3)n2-c2ccc(Cl)cc2C1
Show InChI InChI=1S/C22H23ClN4O2/c23-16-6-9-19-15(11-16)12-17(28)13-20-25-26-22(27(19)20)14-4-7-18(8-5-14)29-21-3-1-2-10-24-21/h1-3,6,9-11,14,17-18,28H,4-5,7-8,12-13H2/t14-,17-,18-/m0/s1
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50038604(3-N3-C6H4CH2CO-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-T...)
Show SMILES CN([C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)Cc1cccc(c1)N=[N+]=[N-]
Show InChI InChI=1S/C62H82N20O13/c1-81(52(87)33-38-11-5-12-39(29-38)79-80-70)49(32-37-18-22-41(84)23-19-37)59(94)78-46(31-35-9-3-2-4-10-35)56(91)73-43(24-25-50(63)85)55(90)77-47(34-51(64)86)57(92)75-44(14-7-27-72-62(68)69)60(95)82-28-8-15-48(82)58(93)74-42(13-6-26-71-61(66)67)54(89)76-45(53(65)88)30-36-16-20-40(83)21-17-36/h2-5,9-12,16-23,29,42-49,83-84H,6-8,13-15,24-28,30-34H2,1H3,(H2,63,85)(H2,64,86)(H2,65,88)(H,73,91)(H,74,93)(H,75,92)(H,76,89)(H,77,90)(H,78,94)(H4,66,67,71)(H4,68,69,72)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
Affinity DataKi:  0.310nMAssay Description:Inhibition constant for V1a receptor of rat liver membraneMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50319774((3-chloro-2'-methylbiphenyl-4-yl)((1S,5R)-1,3,3-tr...)
Show SMILES Cc1ccccc1-c1ccc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)c(Cl)c1
Show InChI InChI=1S/C24H28ClNO/c1-16-7-5-6-8-19(16)17-9-10-20(21(25)11-17)22(27)26-15-24(4)13-18(26)12-23(2,3)14-24/h5-11,18H,12-15H2,1-4H3/t18-,24-/m1/s1
Affinity DataKi:  0.310nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(RAT)
Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM85096(CAS_105077 | NSC_105077 | d(CH2)5Tyr(Me)AVP)
Show SMILES COc1ccc(CC2NC(=O)CC3(CCCCC3)SSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc3ccccc3)NC2=O)C(=O)N2CCCC2C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)cc1
Show InChI InChI=1S/C52H74N14O12S2/c1-78-32-16-14-31(15-17-32)25-35-46(73)63-36(24-30-10-4-2-5-11-30)47(74)61-34(18-19-40(53)67)45(72)64-37(26-41(54)68)48(75)65-38(29-79-80-52(27-43(70)60-35)20-6-3-7-21-52)50(77)66-23-9-13-39(66)49(76)62-33(12-8-22-58-51(56)57)44(71)59-28-42(55)69/h2,4-5,10-11,14-17,33-39H,3,6-9,12-13,18-29H2,1H3,(H2,53,67)(H2,54,68)(H2,55,69)(H,59,71)(H,60,70)(H,61,74)(H,62,76)(H,63,73)(H,64,72)(H,65,75)(H4,56,57,58)
Affinity DataKi:  0.330nMMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50319788(CHEMBL1084325 | N-(2'-methoxy-4'-((1S,5R)-1,3,3-tr...)
Show SMILES COc1cc(ccc1-c1cccc(NC(C)=O)c1)C(=O)N1C[C@]2(C)C[C@H]1CC(C)(C)C2
Show InChI InChI=1S/C26H32N2O3/c1-17(29)27-20-8-6-7-18(11-20)22-10-9-19(12-23(22)31-5)24(30)28-16-26(4)14-21(28)13-25(2,3)15-26/h6-12,21H,13-16H2,1-5H3,(H,27,29)/t21-,26-/m1/s1
Affinity DataKi:  0.370nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50418930(CHEMBL1807278)
Show SMILES CC(CCO)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C21H24Cl2N2O3/c1-14(10-11-26)24-21(28)19(12-15-2-6-17(22)7-3-15)25-20(27)13-16-4-8-18(23)9-5-16/h2-9,14,19,26H,10-13H2,1H3,(H,24,28)(H,25,27)/t14?,19-/m1/s1
Affinity DataKi:  0.372nMAssay Description:Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Institute Genomics Functional (IGF)

Curated by ChEMBL
LigandPNGBDBM50202882((S)-N-(2,3-dichlorobenzyl)-5-(4-cyclohexylpiperazi...)
Show SMILES Clc1cccc(CNC(=O)[C@H](CCC(=O)N2CCN(CC2)C2CCCCC2)N2[C@H](\C=C\c3ccccc3)[C@H](N3[C@H](COC3=O)c3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C42H47Cl2N5O5/c43-33-18-10-15-31(38(33)44)27-45-40(51)35(21-22-37(50)47-25-23-46(24-26-47)32-16-8-3-9-17-32)48-34(20-19-29-11-4-1-5-12-29)39(41(48)52)49-36(28-54-42(49)53)30-13-6-2-7-14-30/h1-2,4-7,10-15,18-20,32,34-36,39H,3,8-9,16-17,21-28H2,(H,45,51)/b20-19+/t34-,35+,36-,39+/m1/s1
Affinity DataKi:  0.380nMAssay Description:Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
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