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Report error Found 1462 Enz. Inhib. hit(s) with Target = 'Voltage-dependent L-type calcium channel subunit alpha-1C'
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataKi:  0.130nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  0.210nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataKi:  0.230nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  0.25nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM82056(CAS_4499 | NSC_4499 | Nisoldipine)
Affinity DataKi:  0.330nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  0.350nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM82056(CAS_4499 | NSC_4499 | Nisoldipine)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318493(3-isopropyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-n...)
Affinity DataKi:  0.560nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318493(3-isopropyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-n...)
Affinity DataKi:  0.790nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50016400(2,6-Dimethyl-4-(2-methylsulfanyl-3-nitro-phenyl)-1...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  1.76nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM79180(2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methy...)
Affinity DataKi:  2nMAssay Description:Binding affinity against rat L-type calcium channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataKi:  2.06nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50231571(CHEMBL3350845)
Affinity DataKi:  2.20nMAssay Description:Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079458(2,6-Dimethyl-4-[3-methyl-5-(2-naphthalen-1-yl-ethy...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318493(3-isopropyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-n...)
Affinity DataKi:  2.28nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50231574(CHEMBL3350842)
Affinity DataKi:  2.40nMAssay Description:Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM82057(CAS_107928 | CAS_65832 | D888,(+) | D888,(-) | NSC...)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM82056(CAS_4499 | NSC_4499 | Nisoldipine)
Affinity DataKi:  2.79nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079458(2,6-Dimethyl-4-[3-methyl-5-(2-naphthalen-1-yl-ethy...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H](+)-PN200-110 binding to calcium channels in guinea pig cardiac membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  4.60nMAssay Description:Invitro evaluation against RXR-alpha in CV-1 cells by cotransfection assay was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079463(4-{5-[2-(3-Bromo-phenyl)-ethyl]-3-phenyl-isoxazol-...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079463(4-{5-[2-(3-Bromo-phenyl)-ethyl]-3-phenyl-isoxazol-...)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H](+)-PN200-110 binding to calcium channels in guinea pig cardiac membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26948(8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-tr...)
Affinity DataKi:  7.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50029426(CHEMBL24675 | [2-(3,4-Dimethoxy-phenyl)-ethyl]-[4-...)
Affinity DataKi:  8.30nMAssay Description:Calcium antagonistic activity by measuring [3H]-nitrendipine displacement from rat heart L-type [Ca2+] channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079459(4-[5-(2-Biphenyl-4-yl-ethyl)-3-methyl-isoxazol-4-y...)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  9nMAssay Description:Inhibition of [3H]nitrendipine binding to membrane homogenates of of rat cardiac muscle.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM82057(CAS_107928 | CAS_65832 | D888,(+) | D888,(-) | NSC...)
Affinity DataKi:  9.10nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50030617(2,6-Dimethyl-4-(4-nitro-phenyl)-pyridine-3,5-dicar...)
Affinity DataKi: >10nMAssay Description:Inhibition of [3H]nitrendipine binding to membrane homogenates of of rat cardiac muscle.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataKi:  10.6nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079464(2,6-Dimethyl-4-[3-methyl-5-(2-naphthalen-2-yl-ethy...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231573(CHEMBL3350846)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013025(2,6-Dimethyl-4-(5-methyl-3-phenyl-isoxazol-4-yl)-1...)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]-PN-200110 binding to Calcium channel in guinea pig heart membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231570(CHEMBL3350843)
Affinity DataKi:  16nMAssay Description:Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231572(CHEMBL3350844)
Affinity DataKi:  17nMAssay Description:Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50042750(CHEMBL410937 | {8-[5-Methoxycarbonyl-2,6-dimethyl-...)
Affinity DataKi:  17nMAssay Description:Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50042752(CHEMBL122740 | {12-[5-Methoxycarbonyl-2,6-dimethyl...)
Affinity DataKi:  17nMAssay Description:Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079459(4-[5-(2-Biphenyl-4-yl-ethyl)-3-methyl-isoxazol-4-y...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H](+)-PN200-110 binding to calcium channels in guinea pig cardiac membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079464(2,6-Dimethyl-4-[3-methyl-5-(2-naphthalen-2-yl-ethy...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H](+)-PN200-110 binding to calcium channels in guinea pig cardiac membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM82061(CAS_119442 | D600 | GALLOPAMIL | NSC_119442)
Affinity DataKi:  21.4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50013025(2,6-Dimethyl-4-(5-methyl-3-phenyl-isoxazol-4-yl)-1...)
Affinity DataKi:  22nMAssay Description:Inhibition of [3H]-PN-200110 binding to Calcium channel in guinea pig heart membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM82061(CAS_119442 | D600 | GALLOPAMIL | NSC_119442)
Affinity DataKi:  22.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50079462(2,6-Dimethyl-4-(3-methyl-5-phenethyl-isoxazol-4-yl...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H](+)-PN200-110 binding to calcium channels in guinea pig cardiac membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079462(2,6-Dimethyl-4-(3-methyl-5-phenethyl-isoxazol-4-yl...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50029415((6-Chloro-4,4-diphenyl-4H-benzo[b]pyrrolo[1,2-d][1...)
Affinity DataKi:  26nMAssay Description:Calcium antagonistic activity by measuring [3H]-nitrendipine displacement from rat heart L-type [Ca2+] channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013022(4-(3,5-Dimethyl-isoxazol-4-yl)-2,6-dimethyl-1,4-di...)
Affinity DataKi:  27nMAssay Description:Inhibition of [3H]-PN-200110 binding to Calcium channel in guinea pig heart membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013022(4-(3,5-Dimethyl-isoxazol-4-yl)-2,6-dimethyl-1,4-di...)
Affinity DataKi:  29nMAssay Description:Inhibition of [3H]-PN-200110 binding to Calcium channel in guinea pig heart membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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