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Report error Found 1123 Enz. Inhib. hit(s) with Target = 'cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B'
LigandPNGBDBM50028190(7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-puri...)
Affinity DataKi:  1nMAssay Description:Inhibitory activity against rabbit lung indole N-methyl-transferase by using S-adenosyl-L-[methyl-3H]-methionine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027177(Cilostamide)
Affinity DataKi:  5nMAssay Description:Binding affinity for low Km cAMP phosphodiesterase PDE III of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027177(Cilostamide)
Affinity DataKi:  20nMAssay Description:Inhibition of human phosphodiesterase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataKi:  150nMAssay Description:Inhibition of human phosphodiesterase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225509(Oxagrelate | SC-32840)
Affinity DataKi:  1.40E+3nMAssay Description:Binding affinity for low Km cAMP phosphodiesterase PDE III of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225504(EHT-0202 | Etazolate | SQ-20009)
Affinity DataKi:  1.20E+4nMAssay Description:Binding affinity for low Km cAMP phosphodiesterase PDE III of sheep lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity for low Km cAMP phosphodiesterase PDE III of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225505(CHEMBL358641 | ICI-58301)
Affinity DataKi:  2.17E+5nMAssay Description:Binding affinity for low Km cAMP phosphodiesterase PDE II of sheep lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225506(CHEMBL150093)
Affinity DataKi:  2.70E+5nMAssay Description:Binding affinity for low Km cAMP phosphodiesterase PDE III of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50028191((R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...)
Affinity DataKi:  1.10E+6nMAssay Description:Inhibitory activity against rabbit lung indole N-methyl-transferase by using S-adenosyl-L-[methyl-3H]-methionine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50028192((S)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...)
Affinity DataKi:  1.20E+6nMAssay Description:Inhibitory activity against catechol O-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229805(CHEMBL327234)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229826(CHEMBL88787)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229833(CHEMBL90877)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229803(CHEMBL329173)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229802(CHEMBL328543)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000927(CHEMBL88108 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229804(CHEMBL90647)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229806(CHEMBL91503)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229764(CHEMBL432057)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229792(CHEMBL329788)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000915(5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-y...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229821(CHEMBL91388)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229814(CHEMBL92165)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000900(CHEMBL90804 | {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229788(CHEMBL91715)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229771(CHEMBL91088)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231553(CHEMBL1203032)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of human platelet aggregation cAMP PDE in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229830(CHEMBL90876)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229796(CHEMBL431085)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229791(CHEMBL330086)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229790(CHEMBL329573)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229770(CHEMBL433183)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231339(CHEMBL1203039)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of human platelet aggregation cAMP PDE in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231400(CHEMBL1203053)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of human platelet aggregation cAMP PDE in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231552(CHEMBL1203031)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of human platelet aggregation cAMP PDE in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229766(CHEMBL91249)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229768(CHEMBL91014)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226700(CHEMBL326891)
Affinity DataIC50:  0.940nMAssay Description:In vivo inhibition of cyclic AMP phosphodiesterase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231396(CHEMBL1203034)
Affinity DataIC50:  1nMAssay Description:Inhibition of human platelet aggregation cAMP PDE in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226561(CHEMBL321600)
Affinity DataIC50:  1nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229794(CHEMBL90176)
Affinity DataIC50:  1nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226571(CHEMBL108876)
Affinity DataIC50:  1nMAssay Description:Binding affinity against sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229762(CHEMBL313021)
Affinity DataIC50:  1nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000909(7-(4-Benzenesulfonyl-butoxy)-1,3-dihydro-imidazo[4...)
Affinity DataIC50:  1nMAssay Description:Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000933(CHEMBL92264 | N-Adamantan-1-yl-4-(2-oxo-2,3-dihydr...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231546(CHEMBL1203024)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human platelet aggregation cAMP PDE in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231537(CHEMBL1203019)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human platelet aggregation cAMP PDE in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231551(CHEMBL1203086)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human platelet aggregation cAMP PDE in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231560(CHEMBL1203083)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human platelet aggregation cAMP PDE in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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