Compile Data Set for Download or QSAR
Report error Found 126 Enz. Inhib. hit(s) with all data for entry = 50038732
TargetGlutamate receptor ionotropic, kainate 1(Human)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252922BDBM50252922((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at human iGluR5(Q)1b expressed in CHO-K1 cells by whole cell patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060627BDBM50060627((S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimid...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060635BDBM50060635((S)-5-Fluorowillardiine | CHEMBL123132 | Fluorowil...)
Affinity DataKi:  2.90nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252920BDBM50252920((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Affinity DataIC50: 3.80nMAssay Description:Antagonist activity at human iGluR5(Q)1b expressed in CHO-K1 cells by whole cell patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060635BDBM50060635((S)-5-Fluorowillardiine | CHEMBL123132 | Fluorowil...)
Affinity DataKi:  4nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, kainate 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252920BDBM50252920((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Affinity DataIC50: 5.20nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252922BDBM50252922((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Affinity DataIC50: 5.30nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50002369BDBM50002369(Digensaeure | (3S,4R)-3-(carboxymethyl)-4-(prop-1-...)
Affinity DataKi:  12.7nMAssay Description:Displacement of [3H]kainic acid from rat recombinant iGluR6(V,C,R) receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252873BDBM50252873(2-amino-3-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-...)
Affinity DataKi:  14.8nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50002370BDBM50002370((RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-p...)
Affinity DataKi:  16.8nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50002370BDBM50002370((RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-p...)
Affinity DataKi:  20.6nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50002370BDBM50002370((RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-p...)
Affinity DataKi:  21.9nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252873BDBM50252873(2-amino-3-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-...)
Affinity DataKi:  35nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060632BDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  37nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 4(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50002370BDBM50002370((RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-p...)
Affinity DataKi:  40nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR4 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50107595BDBM50107595(2-Amino-3-(2,4-dioxo-2,3,4,5,6,7-hexahydro-cyclope...)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060632BDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  45nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060632BDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252922BDBM50252922((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Affinity DataKi:  50nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252920BDBM50252920((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Affinity DataKi:  58nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252873BDBM50252873(2-amino-3-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-...)
Affinity DataKi:  61nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060635BDBM50060635((S)-5-Fluorowillardiine | CHEMBL123132 | Fluorowil...)
Affinity DataKi:  70nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50002369BDBM50002369(Digensaeure | (3S,4R)-3-(carboxymethyl)-4-(prop-1-...)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252920BDBM50252920((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Affinity DataKi:  80nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060627BDBM50060627((S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimid...)
Affinity DataKi:  83nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252921BDBM50252921((S)-1-(2'-Amino-2'-carboxyethyl)-6,6-dimethyl-2,3,...)
Affinity DataKi:  102nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060627BDBM50060627((S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimid...)
Affinity DataKi:  105nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50107595BDBM50107595(2-Amino-3-(2,4-dioxo-2,3,4,5,6,7-hexahydro-cyclope...)
Affinity DataKi:  109nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252922BDBM50252922((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Affinity DataKi:  112nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 4(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060635BDBM50060635((S)-5-Fluorowillardiine | CHEMBL123132 | Fluorowil...)
Affinity DataKi:  123nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR4 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252921BDBM50252921((S)-1-(2'-Amino-2'-carboxyethyl)-6,6-dimethyl-2,3,...)
Affinity DataKi:  126nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  169nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50107595BDBM50107595(2-Amino-3-(2,4-dioxo-2,3,4,5,6,7-hexahydro-cyclope...)
Affinity DataKi:  223nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  249nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  282nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 4(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252920BDBM50252920((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Affinity DataKi:  288nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR4 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252920BDBM50252920((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Affinity DataKi:  311nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  332nMAssay Description:Displacement of [3H]kainic acid from rat recombinant iGluR6(V,C,R) receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 4(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  354nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR4 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 1(Human)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252922BDBM50252922((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Affinity DataIC50: 374nMAssay Description:Antagonist activity at human flip iGluR1 expressed in CHO-K1 cells by whole cell patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060635BDBM50060635((S)-5-Fluorowillardiine | CHEMBL123132 | Fluorowil...)
Affinity DataEC50:  380nMAssay Description:Agonist activity at cyclothiazide-desensitized rat recombinant flip iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50061058BDBM50061058(2-amino-3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl...)
Affinity DataKi:  410nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252873BDBM50252873(2-amino-3-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-...)
Affinity DataKi:  434nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060632BDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  451nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060635BDBM50060635((S)-5-Fluorowillardiine | CHEMBL123132 | Fluorowil...)
Affinity DataEC50:  460nMAssay Description:Agonist activity at cyclothiazide-desensitized rat recombinant flip iGluR2(Q) expressed in Xenopus laevis oocytes by two electrode voltage-clamp elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50002369BDBM50002369(Digensaeure | (3S,4R)-3-(carboxymethyl)-4-(prop-1-...)
Affinity DataKi:  477nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252923BDBM50252923((S)-1-(2'-Amino-2'-carboxyethyl)quinazoline-2,4(1H...)
Affinity DataKi:  490nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 4(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060632BDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  561nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR4 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 4(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252873BDBM50252873(2-amino-3-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-...)
Affinity DataKi:  656nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR4 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
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