Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50033094
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339341((5R)-(-)-N-[1-Ethyl-1-(4-methylphenyl)propyl]-7,7-...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339329(N-(1-Ethyl-1-phenylpropyl)-7,7-dimethyl-5-phenyl-4...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339323(7,7-Dimethyl-N-{1-methyl-1-[4-(trifluoromethyl)phe...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339325(7,7-Dimethyl-5-phenyl-N-{1-propyl-1-[4-(trifluorom...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339341((5R)-(-)-N-[1-Ethyl-1-(4-methylphenyl)propyl]-7,7-...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339320(Ethyl 4-(1-{[(7,7-Dimethyl-5-phenyl-4,5,6,7-tetrah...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339335(N-[1-Ethyl-1-(4-methylphenyl)propyl]-7,7-dimethyl-...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339336(N-[1-Ethyl-1-(4-methoxyphenyl)propyl]-7,7-dimethyl...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339332(N-[1-Ethyl-1-(4-fluorophenyl)propyl]-7,7-dimethyl-...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339330(N-[1-(4-Chlorophenyl)-1-ethylpropyl]-7,7-dimethyl-...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339324(N-{1-Ethyl-1-[4-(trifluoromethyl)phenyl]propyl}-7,...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339337(N-{1-[4-(Benzyloxy)phenyl]-1-ethylpropyl}-7,7-dime...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331964(N-(1-Adamantyl)-7,7-dimethyl-5-phenyl-4,5,6,7-tetr...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339340(N-{1-Ethyl-1-[4-(2-oxobutoxy)phenyl]propyl}-7,7-di...)
Affinity DataIC50: 12nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339334(N-[1-Ethyl-1-(2-fluorophenyl)propyl]-7,7-dimethyl-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339338(4-(1-{[(7,7-Dimethyl-5-phenyl-4,5,6,7-tetrahydropy...)
Affinity DataIC50: 14nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339331(N-[1-(3-Chlorophenyl)-1-ethylpropyl]-7,7-dimethyl-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339326(N-{1-Butyl-1-[4-(trifluoromethyl)phenyl]pentyl}-7,...)
Affinity DataIC50: 23nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339333(N-[1-Ethyl-1-(3-fluorophenyl)propyl]-7,7-dimethyl-...)
Affinity DataIC50: 25nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339327(N-{1-Isopropyl-2-methyl-1-[4-(trifluoromethyl)phen...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339339(4-(1-{[(7,7-Dimethyl-5-phenyl-4,5,6,7-tetrahydropy...)
Affinity DataIC50: 31nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339342((5S)-(+)-N-[1-Ethyl-1-(4-methylphenyl)propyl]-7,7-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331946(N-(1-Adamantyl)-5-phenyl-7-(trifluoromethyl)-4,5,6...)
Affinity DataIC50: 40nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339328(N-{Dicyclohexyl[4-(trifluoromethyl)phenyl]methyl}-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339322((5S,7R)-N-benzhydryl-5-phenyl-7-(trifluoromethyl)-...)
Affinity DataIC50: 380nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50339321((5S,7R)-5-phenyl-7-(trifluoromethyl)-N-(4-(trifluo...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed