BindingDB PrimarySearch_ki

Found 31 Enz. Inhib. hit(s) with all data for entry = 50007125

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506615(CHEMBL4452474)

Ki: 750nMAssay Description:Displacement of [3H]-Paroxetine from recombinant human full length SERT after 60 mins by scintillation countingMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Kappa-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506615(CHEMBL4452474)

Ki: 2.29E+3nMAssay Description:Binding affinity to human full length KOR after 60 mins by radioligand-based scintillation countingMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506615(CHEMBL4452474)

IC50: 2.51E+4nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as reduction in SERT-mediated substrate uptake after 30 mins by fluorescence-based assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50065915(CHEMBL3401461)

EC50: 126nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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3D Structure (crystal)

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506611(CHEMBL4464331)

EC50: 501nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506612(CHEMBL4454531)

EC50: 398nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506613(CHEMBL4453972)

EC50: 316nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506614(CHEMBL4454851)

EC50: 126nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506610(CHEMBL4550415)

EC50: 126nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506615(CHEMBL4452474)

EC50: 100nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Probable G-protein coupled receptor 88(Mus musculus)
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506615(CHEMBL4452474)

EC50: 535nMAssay Description:Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation co...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506613(CHEMBL4453972)

EC50: 316nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506616(CHEMBL4443664)

EC50: 158nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506614(CHEMBL4454851)

EC50: 126nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506615(CHEMBL4452474)

EC50: 100nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506615(CHEMBL4452474)

EC50: 100nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506617(CHEMBL4513479)

EC50: 501nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506609(CHEMBL4583504)

EC50: 63nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506617(CHEMBL4513479)

EC50: 501nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506618(CHEMBL4587388)

EC50: 1.26E+3nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506612(CHEMBL4454531)

EC50: 398nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50065915(CHEMBL3401461)

EC50: 56nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Details Article PubMed PDB

3D Structure (crystal)

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506616(CHEMBL4443664)

EC50: 158nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506615(CHEMBL4452474)

EC50: 100nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50065915(CHEMBL3401461)

EC50: 126nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Details Article PubMed PDB

3D Structure (crystal)

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506618(CHEMBL4587388)

EC50: 1.26E+3nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506619(CHEMBL4456708)

EC50: 96nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506610(CHEMBL4550415)

EC50: 126nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506611(CHEMBL4464331)

EC50: 501nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50506609(CHEMBL4583504)

EC50: 63nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Probable G-protein coupled receptor 88(Mus musculus)
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM50065915(CHEMBL3401461)

EC50: 1.14E+3nMAssay Description:Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation co...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Details Article PubMed PDB

3D Structure (crystal)