Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50023568
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665133BDBM50665133(CHEMBL6151225)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665133BDBM50665133(CHEMBL6151225)
Affinity DataKd:  23nMAssay Description:Binding affinity to CM5 chip-immobilized NLRP3 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665163BDBM50665163(CHEMBL6169322)
Affinity DataKd:  28nMAssay Description:Binding affinity to CM5 chip-immobilized NLRP3 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665149BDBM50665149(CHEMBL6177113)
Affinity DataKd:  59nMAssay Description:Binding affinity to CM5 chip-immobilized NLRP3 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665163BDBM50665163(CHEMBL6169322)
Affinity DataIC50: 180nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665165BDBM50665165(CHEMBL6175635)
Affinity DataIC50: 420nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665149BDBM50665149(CHEMBL6177113)
Affinity DataIC50: 590nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665161BDBM50665161(CHEMBL6176424)
Affinity DataIC50: 710nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665164BDBM50665164(CHEMBL6146603)
Affinity DataIC50: 720nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665154BDBM50665154(CHEMBL6163854)
Affinity DataIC50: 810nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665150BDBM50665150(CHEMBL6168524)
Affinity DataIC50: 890nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665158BDBM50665158(CHEMBL6170627)
Affinity DataIC50: 920nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665159BDBM50665159(CHEMBL6176827)
Affinity DataIC50: 920nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665155BDBM50665155(CHEMBL6168865)
Affinity DataIC50: 940nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665156BDBM50665156(CHEMBL6169664)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665162BDBM50665162(CHEMBL6176216)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665151BDBM50665151(CHEMBL6175535)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665160BDBM50665160(CHEMBL6174609)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665157BDBM50665157(CHEMBL6171883)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051295BDBM50051295(3-Methyl-2-phenyl-quinoline-4-carboxylic acid ((S)...)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051294BDBM50051294(2-Phenyl-quinoline-4-carboxylic acid ((S)-1-phenyl...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665153BDBM50665153(CHEMBL6162450)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50393261BDBM50393261(CHEMBL2152012)
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074773BDBM50074773(2-Phenyl-quinoline-4-carboxylic acid ((R)-1-phenyl...)
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665152BDBM50665152(CHEMBL6168848)
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665148BDBM50665148(CHEMBL6174741)
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051292BDBM50051292((S)-Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665140BDBM50665140(CHEMBL6176331)
Affinity DataIC50: 3.08E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665138BDBM50665138(CHEMBL6164676)
Affinity DataIC50: 4.31E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665144BDBM50665144(CHEMBL6176977)
Affinity DataIC50: 4.51E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665136BDBM50665136(CHEMBL6170009)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665141BDBM50665141(CHEMBL6172120)
Affinity DataIC50: 7.07E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665143BDBM50665143(CHEMBL6162745)
Affinity DataIC50: 7.95E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665134BDBM50665134(CHEMBL6164197)
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665139BDBM50665139(CHEMBL6174385)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665135BDBM50665135(CHEMBL6172875)
Affinity DataIC50: 3.95E+4nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665137BDBM50665137(CHEMBL1278237)
Affinity DataIC50: 7.04E+4nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665142BDBM50665142(CHEMBL6162336)
Affinity DataIC50: 7.70E+4nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665147BDBM50665147(CHEMBL6172747)
Affinity DataIC50: 8.47E+4nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665146BDBM50665146(CHEMBL6165420)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665132BDBM50665132(Chloroquine | Cloroquina | NSC-187208)
Affinity DataIC50: 8.79E+4nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665145BDBM50665145(CHEMBL6175942)
Affinity DataIC50: 1.26E+5nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction IL-1beta release by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed