Compile Data Set for Download or QSAR
maximum 50k data
Found 79 Enz. Inhib. hit(s) with all data for entry = 50005872
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  1.40nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  10nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  11nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  38nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  42nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041943(6-(2,5-Dimethoxy-benzyl)-5-methyl-thieno[2,3-d]pyr...)
Affinity DataIC50:  70nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041929(6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyr...)
Affinity DataIC50:  130nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041927(5,6,7,8,9,10,11,12,13,14-Decahydro-15-thia-1,3-dia...)
Affinity DataIC50:  200nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041939(5-Methyl-6-(3,4,5-trimethoxy-phenyl)-thieno[2,3-d]...)
Affinity DataIC50:  320nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041929(6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyr...)
Affinity DataIC50:  370nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041935(5,6,7,8,9,10-Hexahydro-11-thia-1,3-diaza-cycloocta...)
Affinity DataIC50:  400nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Beef liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041943(6-(2,5-Dimethoxy-benzyl)-5-methyl-thieno[2,3-d]pyr...)
Affinity DataIC50:  400nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041928(7-Benzyl-5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fl...)
Affinity DataIC50:  570nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041934(5-Methyl-6-(3,4,5-trimethoxy-benzyl)-thieno[2,3-d]...)
Affinity DataIC50:  630nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041940(6-Benzyl-5-methyl-thieno[2,3-d]pyrimidine-2,4-diam...)
Affinity DataIC50:  640nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041942(5-Methyl-6-phenyl-thieno[2,3-d]pyrimidine-2,4-diam...)
Affinity DataIC50:  650nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Beef liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041943(6-(2,5-Dimethoxy-benzyl)-5-methyl-thieno[2,3-d]pyr...)
Affinity DataIC50:  730nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041929(6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyr...)
Affinity DataIC50:  750nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041928(7-Benzyl-5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fl...)
Affinity DataIC50:  850nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041941(6,7,8,9-Tetrahydro-5H-10-thia-1,3-diaza-benzo[a]az...)
Affinity DataIC50:  860nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029769(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-thieno...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041940(6-Benzyl-5-methyl-thieno[2,3-d]pyrimidine-2,4-diam...)
Affinity DataIC50:  1.30E+3nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in L. caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041941(6,7,8,9-Tetrahydro-5H-10-thia-1,3-diaza-benzo[a]az...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041941(6,7,8,9-Tetrahydro-5H-10-thia-1,3-diaza-benzo[a]az...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041942(5-Methyl-6-phenyl-thieno[2,3-d]pyrimidine-2,4-diam...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041939(5-Methyl-6-(3,4,5-trimethoxy-phenyl)-thieno[2,3-d]...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041935(5,6,7,8,9,10-Hexahydro-11-thia-1,3-diaza-cycloocta...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041936(6-(3,4-Dichloro-phenyl)-5-methyl-thieno[2,3-d]pyri...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041932(5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041932(5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041931(5-[2-(2,5-Dimethoxy-phenyl)-ethyl]-thieno[2,3-d]py...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029769(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-thieno...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041942(5-Methyl-6-phenyl-thieno[2,3-d]pyrimidine-2,4-diam...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041932(5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041936(6-(3,4-Dichloro-phenyl)-5-methyl-thieno[2,3-d]pyri...)
Affinity DataIC50:  4.60E+3nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Beef liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041936(6-(3,4-Dichloro-phenyl)-5-methyl-thieno[2,3-d]pyri...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041929(6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyr...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041928(7-Benzyl-5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fl...)
Affinity DataIC50:  5.20E+3nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in pneumocystis cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041931(5-[2-(2,5-Dimethoxy-phenyl)-ethyl]-thieno[2,3-d]py...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029769(6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-thieno...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041940(6-Benzyl-5-methyl-thieno[2,3-d]pyrimidine-2,4-diam...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of dihydrofolate reductase in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041935(5,6,7,8,9,10-Hexahydro-11-thia-1,3-diaza-cycloocta...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041930(5-(4-Chloro-phenyl)-6-methyl-thieno[2,3-d]pyrimidi...)
Affinity DataIC50:  7.70E+3nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in L. caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041939(5-Methyl-6-(3,4,5-trimethoxy-phenyl)-thieno[2,3-d]...)
Affinity DataIC50: >8.00E+3nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Beef liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041934(5-Methyl-6-(3,4,5-trimethoxy-benzyl)-thieno[2,3-d]...)
Affinity DataIC50: >8.00E+3nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in Beef liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041933(5-Methyl-6-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-thi...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041927(5,6,7,8,9,10,11,12,13,14-Decahydro-15-thia-1,3-dia...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50041939(5-Methyl-6-(3,4,5-trimethoxy-phenyl)-thieno[2,3-d]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Tested for inhibitory activity against dihydrofolate reductase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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