Compile Data Set for Download or QSAR
maximum 50k data
Found 24 Enz. Inhib. hit(s) with all data for entry = 50047886
LigandPNGBDBM50195475(CHEMBL3393127)
Affinity DataEC50:  3nMAssay Description:Activation of full length human recombinant AMPK alpha1/beta1/gamma1 expressed in baculovirus infected sf21 cells using SAMS peptide substrate after ...More data for this Ligand-Target Pair
LigandPNGBDBM50195534(CHEMBL3957286)
Affinity DataEC50:  11nMAssay Description:Activation of human recombinant AMPK alpha1/beta1/gamma1 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50195476(CHEMBL3938731)
Affinity DataEC50:  3nMAssay Description:Activation of full length human recombinant N-terminal GST-tagged AMPK alpha1/beta1/gamma1 expressed in baculovirus infected High Five cells using NH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM238017(US9394285, 103)
Affinity DataEC50:  8.30nMAssay Description:Activation of full length human phosphorylated His-tagged AMPK alpha1/beta1/gamma1 expressed in Escherichia coli BL21-CodonPlus (DE3)-RIPL using SAMS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase subunit beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50195477(CHEMBL3979403)
Affinity DataEC50:  0.700nMAssay Description:Activation of recombinant human His-tagged AMPK alpha2 (2 to 552 residues)/beta1 (2 to 270 residues)/gamma2 (2 to 569 residues) expressed in baculovi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50434272(CHEMBL1242297)
Affinity DataEC50:  1.20E+4nMAssay Description:Activation of human recombinant AMPK alpha2 expressed in Escherichia coli BL21-CodonPlus (DE3)-RIPL using SAMS peptide after 10 mins in presence of [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM213193(US9290517, 102)
Affinity DataEC50:  5nMAssay Description:Activation of full length human recombinant AMPK alpha2/beta1/gamma1 expressed in baculovirus infected sf21 cells using 5'-FAM-SAMS peptide substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50195478(CHEMBL3959081)
Affinity DataEC50:  1nMAssay Description:Activation of full length human recombinant AMPK alpha1/beta1/gamma1 expressed in baculovirus infected sf21 cells using 5'-FAM-SAMS peptide substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase subunit beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50195479(CHEMBL3950376)
Affinity DataEC50: <500nMAssay Description:Activation of human recombinant AMPK beta1 expressed in African green monkey COS7 cells or baculovirus infected insect cells assessed as increase in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50195480(CHEMBL3906267)
Affinity DataEC50:  40nMAssay Description:Activation of full length human His/GST-tagged AMPK alpha1/beta1/gamma1 expressed in baculovirus expression system after 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50242401(4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-di...)
Affinity DataKd:  487nMAssay Description:Binding affinity for full length human N-terminal His/BAP-tagged AMPK alpha1/beta1/gamma1 expressed in Escherichia coli BL21-CodonPlus by surface pla...More data for this Ligand-Target Pair
LigandPNGBDBM50195533(CHEMBL1882027)
Affinity DataEC50:  1.80E+3nMAssay Description:Activation of human recombinant AMPK GST-tagged alpha1/Myc-tagged beta1/HA-tagged gamma1 expressed in African green monkey COS7 cells assessed as inc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase subunit gamma-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50195534(CHEMBL3957286)
Affinity DataEC50:  2nMAssay Description:Activation of human recombinant AMPK alpha2/beta2/gamma1 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50195534(CHEMBL3957286)
Affinity DataEC50:  27nMAssay Description:Activation of human recombinant AMPK alpha2/beta1/gamma1 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase subunit beta-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50195534(CHEMBL3957286)
Affinity DataEC50:  4nMAssay Description:Activation of human recombinant AMPK alpha2/beta2/gamma3 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50195535(CHEMBL3968290)
Affinity DataEC50:  4nMAssay Description:Activation of full length human recombinant AMPK alpha1/beta1/gamma1 expressed in baculovirus infected sf21 cells using 5'-FAM-SAMS peptide substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50195536(CHEMBL3976962)
Affinity DataEC50:  631nMAssay Description:Activation of full length human His/GST-tagged AMPK alpha1/beta1/gamma1 expressed in baculovirus expression system after 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50195537(CHEMBL3957427)
Affinity DataKd:  74nMAssay Description:Binding affinity for full length human N-terminal His/BAP-tagged AMPK alpha1/beta1/gamma1 expressed in Escherichia coli BL21-CodonPlus by surface pla...More data for this Ligand-Target Pair
LigandPNGBDBM50434272(CHEMBL1242297)
Affinity DataEC50:  300nMAssay Description:Activation of human recombinant AMPK alpha1/beta1/gamma1 expressed in Escherichia coli BL21-CodonPlus (DE3)-RIPL using SAMS peptide after 10 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50195538(CHEMBL3898977)
Affinity DataEC50:  1.20nMAssay Description:Activation of full length human recombinant AMPK alpha1/beta1/gamma1 expressed in baculovirus infected sf21 cells using SAMS peptide substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase subunit beta-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50195479(CHEMBL3950376)
Affinity DataEC50: <5.00E+3nMAssay Description:Activation of human recombinant AMPK beta2 expressed in African green monkey COS7 cells or baculovirus infected insect cells assessed as increase in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50:  4.20nMAssay Description:Activation of full length human phosphorylated His-tagged AMPK alpha1/beta1/gamma1 expressed in Escherichia coli BL21-CodonPlus (DE3)-RIPL using SAMS...More data for this Ligand-Target Pair
LigandPNGBDBM50195534(CHEMBL3957286)
Affinity DataEC50:  4nMAssay Description:Activation of human recombinant AMPK alpha1/beta2/gamma1 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50434272(CHEMBL1242297)
Affinity DataEC50:  8.00E+3nMAssay Description:Activation of human recombinant AMPK alpha1 (1 to 394 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIPL using SAMS peptide after 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed