Reaction Details
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Cell Reactant:
BDBM14831
Syringe Reactant:
5-hydroxytryptamine receptor 2A
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
2007-04-16
pH:
7.0000±n/a
Temperature:
298.1500±n/a (K)
ΔHobs :
-5.6±0.04 (kJ/mole)
Corrected for ΔHioniz:
no
Citation

Cell React
Name:
BDBM14831
Synonyms:
diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-(4-chlorophenyl)urea | 3-(4-chlorophenyl)-1-(2-methyl-5-tert-butyl-pyrazol-3-yl)urea | CHEMBL87277 | diaryl urea inhibitor 1 | Dopamine D2 receptor and serotonin 2a receptor
Type:
Small organic molecule
Emp. Form.:
C15H19ClN4O
Mol. Mass.:
306.80
SMILES:
Cn1nc(C(C)(C)C)cc1NC(=O)Nc1ccc(Cl)cc1
Syringe React
Source:
The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.
Prep. Method:
Soluble murine p38R was extracted from cell pellets and purified by using ion-exchange chromatography. Column fractions were concentrated, analyzed by SDS-PAGE, and pooled based on purity.
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
Serotonin receptor 2A | 5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Human
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV