Cell Reactant:
Serine/threonine-protein kinase Aurora-A
Syringe Reactant:
BDBM87048
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
06/18/12
pH:
7.4±0
Temperature:
298.15±0 (K)
ΔH° :
-59±0 (kJ/mole)
ΔS° :
0.047±0 (kJ/mole-K)
Citation
 Martin, MPZhu, JYLawrence, HRPireddu, RLuo, YAlam, ROzcan, SSebti, SMLawrence, NJSchönbrunn, E A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A. ACS Chem Biol 7:698-706 (2012) [PubMed]  Article 
Cell React
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Syringe React
Name:
BDBM87048
Synonyms:
Bisanilinopyrimidine inhibitor, 2 | Bisanilinopyrimidine, 1 | US9249124, 1
Type:
Small organic molecule
Emp. Form.:
C18H14N4O4
Mol. Mass.:
350.3282
SMILES:
OC(=O)c1ccc(Nc2nccc(Nc3ccccc3C(O)=O)n2)cc1
Structure:
Search PDB for entries with ligand similarity: