Reaction Details  Report a problem with these data
Cell Reactant:
Induced myeloid leukemia cell differentiation protein Mcl-1 (aa 172-327)
Syringe Reactant:
BDBM50400179
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
03/20/14
ΔG°:
-8.01±0 (kcal/mole)
pH:
8±0
Temperature:
298.15±0 (K)
ΔH° :
-5.22±0 (kJ/mole)
ΔS° :
0.01±0 (kJ/mole-K)
Citation
 Zhang, Z; Zhao, Y; Song, T; Liu, Y; Li, X; Su, P; Xie, S Study of binding thermodynamics in the optimization of BH3 mimetics. Chem Biol Drug Des 82:394-400 (2013) [PubMed]  Article 
Cell React
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [172-327]
Synonyms:
BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1 (aa 172-327) | MCL1 | MCL1_HUMAN | Mcl-1 (aa 172-327) | Mcl-1 (residues 172-327)
Type:
n/a
Mol. Mass.:
17768.02
Organism:
Homo sapiens (Human)
Description:
Q07820[172-327]
Residue:
156
Sequence:
DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
  
Syringe React
Name:
BDBM50400179
Synonyms:
2,3‐dihydroxy‐6‐(phenylsulfanyl)anthracene‐9,10‐ dione (Ligand 4) | CHEMBL2180319
Type:
Small organic molecule
Emp. Form.:
C20H12O4S
Mol. Mass.:
348.372
SMILES:
Oc1cc2C(=O)c3ccc(Sc4ccccc4)cc3C(=O)c2cc1O
Structure:
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