Reaction Details 
Report a problem with these data
Report a problem with these dataCell Reactant:
MAP kinase ERK1
Syringe Reactant:
BDBM103302
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2014-10-22
ΔG°:
-36.7500±n/a (kJ/mole)
pH:
7.5000±0.0000
Temperature:
288.1500±0.0000 (K)
ΔH° :
-86.2000±0.8000 (kJ/mole)
ΔS° :
-0.1716±0.0000 (kJ/mole-K)
Citation
Chaikuad, A; Tacconi, EM; Zimmer, J; Liang, Y; Gray, NS; Tarsounas, M; Knapp, S A unique inhibitor binding site in ER K1/2 is associated with slow binding kinetics Nat Chem Biol 10:853-860 (2014) [PubMed] Article More Info.:
Cell React
Name:
Mitogen-activated protein kinase 3
Synonyms:
MAP kinase ERK1 | Mitogen-activated protein kinase | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MK03_HUMAN | MAPK3 | ERK1 | PRKM3 | Mitogen-activated protein kinase 3 | MAPK3/MAPK7
Type:
Protein
Mol. Mass.:
43136.58
Organism:
Human
Description:
curated by PDB 4QTB
Residue:
379
Sequence:
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP
Syringe React
Name:
BDBM103302
Synonyms:
SCH772984 | US8546404, 6
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
