Reaction Details Report a problem with these data
Cell Reactant:
Cyclin-dependent protein kinase 2 variant (CDK2 C118L)
Syringe Reactant:
BDBM154576
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
10/15/15
ΔG°:
-10.22±0 (kcal/mole)
pH:
7.5±0
Temperature:
288.15±0 (K)
ΔH° :
-14.97±n/a (kJ/mole)
ΔHobs :
-15.02±0 (kJ/mole)
ΔS° :
-0.02±0 (kJ/mole-K)
Citation
Alexander, LT; Möbitz, H; Drueckes, P; Savitsky, P; Fedorov, O; Elkins, JM; Deane, CM; Cowan-Jacob, SW; Knapp, S Type II Inhibitors Targeting CDK2. ACS Chem Biol 10:2116-25 (2015) [PubMed] Article
More Info.:
Cell React
Name:
Cyclin-dependent kinase 2 [C118L]
Synonyms:
CDK2 | CDK2_HUMAN | CDKN2 | Cyclin-dependent protein kinase 2 variant (CDK2 C118L)
Type:
Protein
Mol. Mass.:
33948.19
Organism:
Homo sapiens (Human)
Description:
CDK2 mutant (C118L)
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFLHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL