Reaction Details  Report a problem with these data
Cell Reactant:
Serine/threonine-protein kinase Aurora-B
Syringe Reactant:
BDBM189379
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2016-08-03
ΔG°:
-36.0000±2.0000 (kJ/mole)
pH:
8.0000±0.0000
Temperature:
298.1500±0.0000 (K)
ΔH° :
-13.0000±2.0000 (kJ/mole)
ΔS° :
-0.0765±0.0030 (kJ/mole-K)
Citation
 Karthigeyan, D; Surabhi, S; Mizar, P; Soumik, S; Banerjee, A; Sinha, SH; Dasgupta, D; Narayana, C; Kundu, TK A Dual Non-ATP Analogue Inhibitor of Aurora Kinases A and B, Derived from Resorcinol with a Mixed Mode of Inhibition. Chem Biol Drug Des 87:958-67 (2016) [PubMed]  Article 
Cell React
Name:
Aurora kinase B
Synonyms:
Aurora kinase 2 | Aurora kinase B (AURKB) | AIM-1 | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora-related kinase 2 | STK-1 | Serine/threonine-protein kinase aurora B | AURKB_HUMAN | AURKB | AIK2 | AIM1 | AIRK2 | ARK2 | STK1 | STK12 | STK5
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Human
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Syringe React
Name:
BDBM189379
Synonyms:
5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | Felodipine
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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