Reaction Details  Report a problem with these data
Cell Reactant:
Ephrin type-A receptor 4 ligand binding domain (D61G/E62G-EphA4-LBD)
Syringe Reactant:
BDBM223311
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2017-04-27
ΔG°:
-36.7000±n/a (kJ/mole)
pH:
6.5000±0.0000
Temperature:
300.1500±0.0000 (K)
ΔH° :
-38.2000±0.5900 (kJ/mole)
ΔS° :
-0.0050±0.0000 (kJ/mole-K)
Citation
 Wu, B; De, SK; Kulinich, A; Salem, AF; Koeppen, J; Wang, R; Barile, E; Wang, S; Zhang, D; Ethell, I; Pellecchia, M Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol 24:293-305 (2017) [PubMed]  Article 
Cell React
Name:
Ephrin type-A receptor 4 [29-209,D61G,E62G]
Synonyms:
EPHA4_HUMAN | EPHA4 | HEK8 | SEK | TYRO1 | Ephrin type-A receptor 4 ligand binding domain (D61G/E62G-EphA4-LBD)
Type:
Protein
Mol. Mass.:
20722.36
Organism:
Human
Description:
Human EphA4-LBD D61G/E62G double mutant
Residue:
181
Sequence:
NEVTLLDSRSVQGELGWIASPLEGGWEEVSIMGGKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVR
  
Syringe React
Name:
BDBM223311
Synonyms:
123C4
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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