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Target
Protein-tyrosine kinase 6
Ligand
BDBM514125
Substrate
n/a
Meas. Tech.
Measurement of Brk Inhibitory Activity
IC50
11.0±n/a nM
Citation
 Yamamoto, S; Kurono, M; Yoshida, A; Hotta, S BRK inhibitory compound US Patent  US11052091 Publication Date 7/6/2021 
Target
Name:
Protein-tyrosine kinase 6
Synonyms:
BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:
Tyrosine-protein kinase
Mol. Mass.:
51839.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
  
Inhibitor
Name:
BDBM514125
Synonyms:
US11052091, Example 4
Type:
Small organic molecule
Emp. Form.:
C23H21FN8O2
Mol. Mass.:
460.4636
SMILES:
CC(C)n1c2nc(Nc3ccc(cc3F)C(C)=O)nc(N)c2n(-c2cccc3[nH]ncc23)c1=O |(3.18,-4.74,;4.27,-3.65,;5.75,-4.05,;3.87,-2.17,;2.4,-1.69,;1.07,-2.46,;-.26,-1.69,;-1.6,-2.46,;-2.93,-1.69,;-2.93,-.15,;-4.26,.62,;-5.6,-.15,;-5.6,-1.69,;-4.26,-2.46,;-4.26,-4,;-6.93,.62,;-8.27,-.15,;-6.93,2.16,;-.26,-.15,;1.07,.62,;1.07,2.16,;2.4,-.15,;3.87,.33,;4.27,1.81,;3.24,2.96,;3.71,4.42,;5.22,4.74,;6.25,3.6,;7.79,3.6,;8.27,2.13,;7.02,1.23,;5.77,2.13,;4.77,-.92,;6.31,-.92,)|
Structure:
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