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Target
Protein-tyrosine kinase 6
Ligand
BDBM514127
Substrate
n/a
Meas. Tech.
Measurement of Brk Inhibitory Activity
IC50
5.00±n/a nM
Citation
 Yamamoto, S; Kurono, M; Yoshida, A; Hotta, S BRK inhibitory compound US Patent  US11052091 Publication Date 7/6/2021 
Target
Name:
Protein-tyrosine kinase 6
Synonyms:
BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:
Tyrosine-protein kinase
Mol. Mass.:
51839.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
  
Inhibitor
Name:
BDBM514127
Synonyms:
US11052091, Example 5-2
Type:
Small organic molecule
Emp. Form.:
C23H21FN8O3S
Mol. Mass.:
508.528
SMILES:
CS(=O)(=O)c1ccc(Nc2nc(N)c3n(-c4cccc5[nH]ncc45)c(=O)n(C4CCC4)c3n2)c(F)c1 |(6.39,5.62,;6.39,4.08,;4.85,4.08,;7.93,4.08,;6.39,2.54,;7.73,1.77,;7.73,.23,;6.39,-.54,;6.39,-2.08,;5.06,-2.85,;5.06,-4.39,;3.73,-5.16,;3.73,-6.7,;2.39,-4.39,;.93,-4.87,;.45,-6.33,;1.48,-7.48,;1.01,-8.94,;-.5,-9.26,;-1.53,-8.12,;-3.07,-8.12,;-3.55,-6.65,;-2.3,-5.75,;-1.05,-6.65,;.02,-3.62,;-1.52,-3.62,;.93,-2.37,;.45,-.91,;-.92,-.21,;-.22,1.16,;1.15,.46,;2.39,-2.85,;3.73,-2.08,;5.06,.23,;3.73,-.54,;5.06,1.77,)|
Structure:
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