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Target
Protein-tyrosine kinase 6
Ligand
BDBM514129
Substrate
n/a
Meas. Tech.
Measurement of Brk Inhibitory Activity
IC50
6.00±n/a nM
Citation
 Yamamoto, S; Kurono, M; Yoshida, A; Hotta, S BRK inhibitory compound US Patent  US11052091 Publication Date 7/6/2021 
Target
Name:
Protein-tyrosine kinase 6
Synonyms:
BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:
Tyrosine-protein kinase
Mol. Mass.:
51839.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
  
Inhibitor
Name:
BDBM514129
Synonyms:
US11052091, Example 5-4
Type:
Small organic molecule
Emp. Form.:
C23H23FN8O3S
Mol. Mass.:
510.544
SMILES:
CC(C)n1c2nc(Nc3ccc(cc3F)S(C)(=O)=O)nc(N)c2n(-c2ccc(C)c3[nH]ncc23)c1=O |(-1.05,-.59,;.45,-.91,;1.48,.24,;.93,-2.37,;2.39,-2.85,;3.73,-2.08,;5.06,-2.85,;6.39,-2.08,;6.39,-.54,;7.73,.23,;7.73,1.77,;6.39,2.54,;5.06,1.77,;5.06,.23,;3.73,-.54,;6.39,4.08,;6.39,5.62,;4.85,4.08,;7.93,4.08,;5.06,-4.39,;3.73,-5.16,;3.73,-6.7,;2.39,-4.39,;.93,-4.87,;.45,-6.33,;1.48,-7.48,;1.01,-8.94,;-.5,-9.26,;-.97,-10.72,;-1.53,-8.12,;-3.07,-8.12,;-3.55,-6.65,;-2.3,-5.75,;-1.05,-6.65,;.02,-3.62,;-1.52,-3.62,)|
Structure:
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