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Target
Protein-tyrosine kinase 6
Ligand
BDBM514130
Substrate
n/a
Meas. Tech.
Measurement of Brk Inhibitory Activity
IC50
7.00±n/a nM
Citation
 Yamamoto, S; Kurono, M; Yoshida, A; Hotta, S BRK inhibitory compound US Patent  US11052091 Publication Date 7/6/2021 
Target
Name:
Protein-tyrosine kinase 6
Synonyms:
BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:
Tyrosine-protein kinase
Mol. Mass.:
51839.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
  
Inhibitor
Name:
BDBM514130
Synonyms:
US11052091, Example 5-5
Type:
Small organic molecule
Emp. Form.:
C24H21F3N8O3S
Mol. Mass.:
558.536
SMILES:
CS(=O)(=O)c1ccc(Nc2nc(N)c3n(-c4cccc5[nH]ncc45)c(=O)n(C4CCC(F)(F)C4)c3n2)c(F)c1 |(-8.27,2.41,;-6.93,1.64,;-8.27,.87,;-6.93,3.18,;-5.6,.87,;-4.26,1.64,;-2.93,.87,;-2.93,-.67,;-1.6,-1.44,;-.26,-.67,;-.26,.87,;1.07,1.64,;1.07,3.18,;2.4,.87,;3.87,1.35,;4.27,2.84,;3.24,3.98,;3.71,5.45,;5.22,5.77,;6.25,4.62,;7.79,4.62,;8.27,3.16,;7.02,2.25,;5.77,3.16,;4.77,.1,;6.31,.1,;3.87,-1.14,;4.27,-2.63,;3.36,-3.88,;4.27,-5.12,;5.73,-4.65,;7.07,-3.88,;7.07,-5.42,;5.73,-3.11,;2.4,-.67,;1.07,-1.44,;-4.26,-1.44,;-4.26,-2.98,;-5.6,-.67,)|
Structure:
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