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Target
Protein-tyrosine kinase 6
Ligand
BDBM514134
Substrate
n/a
Meas. Tech.
Measurement of Brk Inhibitory Activity
IC50
2.00±n/a nM
Citation
 Yamamoto, S; Kurono, M; Yoshida, A; Hotta, S BRK inhibitory compound US Patent  US11052091 Publication Date 7/6/2021 
Target
Name:
Protein-tyrosine kinase 6
Synonyms:
BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:
Tyrosine-protein kinase
Mol. Mass.:
51839.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
  
Inhibitor
Name:
BDBM514134
Synonyms:
US11052091, Example 5-16
Type:
Small organic molecule
Emp. Form.:
C27H26ClF3N8O3
Mol. Mass.:
602.995
SMILES:
Nc1nc(Nc2ccc(cc2F)C(=O)N2CCNCC2)nc2n(C3CCC(F)(F)C3)c(=O)n(-c3ccc(Cl)c(O)c3)c12
Structure:
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