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Target
Dual specificity mitogen-activated protein kinase kinase 1
Ligand
BDBM50014412
Substrate
n/a
Meas. Tech.
MEK 1/2 inhibition
IC50
<1000±n/a nM
Citation
 Choi, K; Kim, M; Han, S Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition US Patent  US11147816 Publication Date 10/19/2021 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 1
Synonyms:
ERK activator kinase 1 | Mitogen-activated protein kinase 1 (MEK1) | MAPK/ERK kinase 1 (MEK1) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK) | MEK-1 | MAP kinase kinase 1 | MAPK/ERK kinase 1 | Dual specificity mitogen-activated protein kinase (MEK) | Dual specificity mitogen-activated protein kinase kinase MEK1/2 | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) | MP2K1_HUMAN | MAP2K1 | MEK1 | PRKMK1 | VHL-MAP2K1/MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase
Type:
Other Protein Type
Mol. Mass.:
43439.03
Organism:
Human
Description:
Full-length human MEK-1 was generated by PCR and purified as a fusion protein from Escherichia coli lysates.
Residue:
393
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
  
Inhibitor
Name:
BDBM50014412
Synonyms:
Pimasertib | US11147816, Pimasertib (AS703026) | US11701360, Pimasertib
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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