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Target
Envelope glycoprotein
Ligand
BDBM521549
Substrate
n/a
Meas. Tech.
Ebola Antiviral Assay (EBOV)
EC50
200±n/a nM
Citation
 Beigelman, L; Deval, J; Prhavc, M Substituted nucleosides, nucleotides and analogs thereof US Patent  US11149049 Publication Date 10/19/2021 
Target
Name:
Envelope glycoprotein
Synonyms:
Envelope glycoprotein | GP | GP1 | GP1,2 | GP1,2-delta | GP2 | Shed GP | VGP_EBOZM
Type:
PROTEIN
Mol. Mass.:
74464.56
Organism:
ZEBOV
Description:
ChEMBL_117434
Residue:
676
Sequence:
MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTVVSNGAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAMVQVHSQGREAAVSHLTTLATISTSPQSLTTKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNDSTASDTPSATTAAGPPKAENTNTSKSTDFLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRTRREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYIEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF
  
Inhibitor
Name:
BDBM521549
Synonyms:
Diisopentyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-2-fluoro-3,4-dihdroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-aspartate | US11149049, No. 7
Type:
Small organic molecule
Emp. Form.:
C32H42FN6O10P
Mol. Mass.:
720.6822
SMILES:
CC(C)CCOC(=O)C[C@H](NP(=O)(OC[C@@]1(F)O[C@](C#N)([C@H](O)[C@@H]1O)c1ccc2c(N)ncnn12)Oc1ccccc1)C(=O)OCCC(C)C |r|
Structure:
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