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Target
Genome polyprotein
Ligand
BDBM50236025
Substrate
n/a
Meas. Tech.
Rhinovirus Polymerase (HRV1bpol) and HCV Polymerase (HCVpol) Assays
IC50
270±n/a nM
Citation
 Beigelman, L; Deval, J; Prhavc, M Substituted nucleosides, nucleotides and analogs thereof US Patent  US11149049 Publication Date 10/19/2021 
Target
Name:
Genome polyprotein
Synonyms:
POLG_HRV16
Type:
PROTEIN
Mol. Mass.:
242260.90
Organism:
HRV-16
Description:
ChEMBL_523531
Residue:
2153
Sequence:
MGAQVSRQNVGTHSTQNMVSNGSSLNYFNINYFKDAASSGASRLDFSQDPSKFTDPVKDVLEKGIPTLQSPSVEACGYSDRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDATAIDKPTQPDTSSNRFYTLDSKMWNSTSKGWWWKLPDALKDMGIFGENMFYHFLGRSGYTVHVQCNASKFHQGTLLVVMIPEHQLATVNKGNVNAGYKYTHPGEAGREVGTQVENEKQPSDDNWLNFDGTLLGNLLIFPHQFINLRSNNSATLIVPYVNAVPMDSMVRHNNWSLVIIPVCQLQSNNISNIVPITVSISPMCAEFSGARAKTVVQGLPVYVTPGSGQFMTTDDMQSPCALPWYHPTKEIFIPGEVKNLIEMCQVDTLIPINSTQSNIGNVSMYTVTLSPQTKLAEEIFAIKVDIASHPLATTLIGEIASYFTHWTGSLRFSFMFCGTANTTLKVLLAYTPPGIGKPRSRKEAMLGTHVVWDVGLQSTVSLVVPWISASQYRFTTPDTYSSAGYITCWYQTNFVVPPNTPNTAEMLCFVSGCKDFCLRMARDTDLHKQTGPITQNPVERYVDEVLNEVLVVPNINQSHPTTSNAAPVLDAAETGHTNKIQPEDTIETRYVQSSQTLDEMSVESFLGRSGCIHESVLDIVDNYNDQSFTKWNINLQEMAQIRRKFEMFTYARFDSEITMVPSVAAKDGHIGHIVMQYMYVPPGAPIPTTRDDYAWQSGTNASVFWQHGQPFPRFSLPFLSIASAYYMFYDGYDGDTYKSRYGTVVTNDMGTLCSRIVTSEQLHKVKVVTRIYHKAKHTKAWCPRPPRAVQYSHTHTTNYKLSSEVHNDVAIRPRTNLTTVGPSDMYVHVGNLIYRNLHLFNSDIHDSILVSYSSDLIIYRTSTQGDGYIPTCNCTEATYYCKHKNRYYPINVTPHDWYEIQESEYYPKHIQYNLLIGEGPCEPGDCGGKLLCKHGVIGIITAGGEGHVAFIDLRHFHCAEEQGITDYIHMLGEAFGSGFVDSVKDQINSINPINNISSKMVKWMLRIISAMVIIIRNSSDPQTIIATLTLIGCNGSPWRFLKEKFCKWTQLTYIHKESDSWLKKFTEMCNAARGLEWIGNKISKFIDWMKSMLPQAQLKVKYLSELKKLNFLEKQVENLRAADTNTQEKIKCEIDTLHDLSCKFLPLYASEAKRIKVLYHKCTNIIKQKKRSEPVAVMIHGPPGTGKSITTSFLARMITNESDIYSLPPDPKYFDGYDNQSVVIMDDIMQNPGGEDMTLFCQMVSSVTFIPPMADLPDKGKPFDSRFVLCSTNHSLLAPPTISSLPAMNRRFYLDLDILVHDNYKDNQGKLDVSRAFRLCDVDSKIGNAKCCPFVCGKAVTFKDRNTCRTYSLSQIYNQILEEDKRRRQVVDVMSAIFQGPISMDKPPPPAITDLLRSVRTPEVIKYCQDNKWIVPADCQIERDLNIANSIITIIANIISIAGIIYIIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGMSIIKNNTCVVTTTNGKFTGLGIYDRILILPTHADPGSEIQVNGIHTKVLDSYDLFNKEGVKLEITVLKLDRNEKFRDIRKYIPESEDDYPECNLALVANQTEPTIIKVGDVVSYGNILLSGTQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSSMLLRSYFTEQQGQIQISKHVKDVGLPSIHTPTKTKLQPSVFYDIFPGSKEPAVLTEKDPRLKVDFDSALFSKYKGNTECSLNEHIQVAVAHYSAQLATLDIDPQPIAMEDSVFGMDGLEALDLNTSAGYPYVTLGIKKKDLINNKTKDISKLKLALDKYDVDLPMITFLKDELRKKDKIAAGKTRVIEASSINDTILFRTVYGNLFSKFHLNPGVVTGCAVGCDPETFWSKIPLMLDGDCIMAFDYTNYDGSIHPIWFKALGMVLDNLSFNPTLINRLCNSKHIFKSTYYEVEGGVPSGCSGTSIFNSMINNIIIRTLVLDAYKHIDLDKLKIIAYGDDVIFSYKYKLDMEAIAKEGQKYGLTITPADKSSEFKELDYGNVTFLKRGFRQDDKYKFLIHPTFPVEEIYESIRWTKKPSQMQEHVLSLCHLMWHNGPEIYKDFETKIRSVSAGRALYIPPYELLRHEWYEKF
  
Inhibitor
Name:
BDBM50236025
Synonyms:
CHEMBL2016761 | US11149049, No. C2 | US20240140975, Compound A109
Type:
Small organic molecule
Emp. Form.:
C12H16N5O13P3
Mol. Mass.:
531.2024
SMILES:
Nc1ncnn2c(ccc12)[C@@]1(O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C#N |r|
Structure:
Search PDB for entries with ligand similarity: