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Target
Procathepsin L
Ligand
BDBM50031706
Substrate
n/a
Meas. Tech.
TMPRSS2 pericellular activity screening assay
Ki
>10000±n/a nM
Citation
 Shapira, T; Monreal, IA; Dion, SP; Buchholz, DW; Imbiakha, B; Olmstead, AD; Jager, M; Désilets, A; Gao, G; Martins, M; Vandal, T; Thompson, CAH; Chin, A; Rees, WD; Steiner, T; Nabi, IR; Marsault, E; Sahler, J; Diel, DG; Van de Walle, GR; August, A; Whittaker, GR; Boudreault, PL; Leduc, R; Aguilar, HC; Jean, F A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic. Nature 0:0 (2022) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
Cathepsin L1 | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein | CTSL CTSL1 | CATL1_HUMAN | CTSL | CTSL1
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Human
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50031706
Synonyms:
4-Guanidino-benzoic acid 4-dimethylcarbamoylmethoxycarbonylmethyl-phenyl ester; compound with methanesulfonic acid | CHEMBL85164 | Camostat | med.21724, Compound 18
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
[#6]-[#7](-[#6])-[#6](=O)-[#6]-[#8]-[#6](=O)-[#6]-c1ccc(-[#8]-[#6](=O)-c2ccc(cc2)\[#7]=[#6](/[#7])-[#7])cc1
Structure:
Search PDB for entries with ligand similarity: