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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM427037
Substrate
n/a
Meas. Tech.
Radiolabel Binding Assay
IC50
7.50±n/a nM
Citation
 Canney, DJ; Blass, BE; Gao, R; Abou-Gharbia, M 5-hydroxytryptamine receptor 7 activity modulators and their method of use US Patent  US11192871 Publication Date 12/7/2021
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM427037
Synonyms:
US10544117, Entry 230070 | US11192871, Example 230070
Type:
Small organic molecule
Emp. Form.:
C19H26ClNO2
Mol. Mass.:
335.868
SMILES:
CCC1(CC)CC(CCN2CCc3ccc(Cl)cc3C2)OC1=O
Structure:
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