Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK2 [808-1132]
Ligand
BDBM50332294
Substrate
n/a
Meas. Tech.
Biochemical Activity Assay
IC50
8.00±n/a nM
Citation
 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Aza-indazole compounds for use in tendon and/or ligament injuries US Patent  US11203595 Publication Date 12/21/2021 
Target
Name:
Tyrosine-protein kinase JAK2 [808-1132]
Synonyms:
JAK2 (aa 808-1132) | Tyrosine-protein kinase JAK2 JH1 (808-1132) | JAK2_HUMAN | JAK2
Type:
Protein
Mol. Mass.:
39171.39
Organism:
Human
Description:
O60674[808-1132]
Residue:
335
Sequence:
FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM50332294
Synonyms:
N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide | CHEMBL1287853 | US10112907, Example 00018 | US10730860, TABLE 1.3 | US10766894, Compound TABLE 1.3 | US11203595, TABLE 1.3 | US11384069, Example T-5 | US20240140952, Compound Fedratinib
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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