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Target
RNA guanine-N7 methyltransferase activating subunit
Ligand
BDBM533526
Substrate
n/a
Meas. Tech.
MTase Filter-Binding Assay (FBA)
IC50
52800±8310 nM
Citation
 Ahmed-Belkacem, R; Hausdorff, M; Delpal, A; Sutto-Ortiz, P; Colmant, AMG; Touret, F; Ogando, NS; Snijder, EJ; Canard, B; Coutard, B; Vasseur, JJ; Decroly, E; Debart, F Potent Inhibition of SARS-CoV-2 nsp14  J Med Chem 65:6231-6249 (2022) [PubMed]  Article 
Target
Name:
RNA guanine-N7 methyltransferase activating subunit
Synonyms:
C15orf18 | FAM103A1 | Protein FAM103A1 | RAM | RAMAC | RAMAC_HUMAN | RAMMET | RNA guanine-7 methyltransferase activating subunit | RNMT-activating mRNA cap methyltransferase subunit | RNMT-activating mini protein
Type:
n/a
Mol. Mass.:
14384.82
Organism:
Human
Description:
Q9BTL3
Residue:
118
Sequence:
MTDTAEAVPKFEEMFASRFTENDKEYQEYLKRPPESPPIVEEWNSRAGGNQRNRGNRLQDNRQFRGRDNRWGWPSDNRSNQWHGRSWGNNYPQHRQEPYYPQQYGHYGYNQRPPYGYY
  
Inhibitor
Name:
BDBM533526
Synonyms:
jm2c00120, Compound 25
Type:
Small Organic Molecule
Emp. Form.:
C20H23N7O6S
Mol. Mass.:
489.505
SMILES:
CCN(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)S(=O)(=O)c1ccc(OC)c(c1)C#N
Structure:
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