Target
Eukaryotic translation initiation factor 4E-binding protein 1
Ligand
BDBM545738
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
IC50
1.11±n/a nM
Citation
 Sperry, SXiang, AXErnst, JTReich, SHSprengeler, PAShaghafi, MMichels, TNilewski, CTran, CVPackard, GKGrubbs, AUrkalan, KMukaiyama, T EIF4E-inhibiting compounds and methods US Patent  US11286268 Publication Date 3/29/2022
Target
Name:
Eukaryotic translation initiation factor 4E-binding protein 1
Synonyms:
GFP-4EBP | GFP-4EBP1 | Green fluorescent protein-Eukaryotic initiation factor 4E (eIF4E) binding protein
Type:
Fusion protein
Mol. Mass.:
12578.35
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
118
Sequence:
MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI
  
Inhibitor
Name:
BDBM545738
Synonyms:
US11286268, Compound 1228
Type:
Small organic molecule
Emp. Form.:
C32H26ClF3N10O2S
Mol. Mass.:
707.128
SMILES:
CN1CCN(CC1)c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3ccnc4c(csc34)-c3nn[nH]n3)c(=O)c2c1C#N)C(F)(F)F
Structure:
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