Reaction Details Report a problem with these data
Target
Interleukin-17 receptor A/
Ligand
BDBM548009
Substrate
n/a
Meas. Tech.
Human IL-17A x IL-17RA TR-FRET assay
IC50
24±n/a nM
Citation
 Josef, TT; David, O; Pascal, F; Klaus, W; Achim, S INTERLEUKIN-17 INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Interleukin-17 receptor A/
Synonyms:
Human IL-17A/IL-17RA | Interleukin-17A/Interleukin-17 receptor A
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Interleukin-17A
Synonyms:
CTLA8 | Cytotoxic T-lymphocyte-associated antigen 8 | IL-17 | IL17 | IL17A | IL17_HUMAN | il-17a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17511.44
Organism:
Homo sapiens (Human)
Description:
Q16552
Residue:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  
Component 2
Name:
Interleukin-17 receptor A
Synonyms:
CDw217 | I17RA_HUMAN | IL-17 receptor A | IL-17RA | IL17R | IL17RA
Type:
Protein
Mol. Mass.:
96092.10
Organism:
Human
Description:
Q96F46
Residue:
866
Sequence:
MGAARSPPSAVPGPLLGLLLLLLGVLAPGGASLRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLWVYWFITGISILLVGSVILLIVCMTWRLAGPGSEKYSDDTKYTDGLPAADLIPPPLKPRKVWIIYSADHPLYVDVVLKFAQFLLTACGTEVALDLLEEQAISEAGVMTWVGRQKQEMVESNSKIIVLCSRGTRAKWQALLGRGAPVRLRCDHGKPVGDLFTAAMNMILPDFKRPACFGTYVVCYFSEVSCDGDVPDLFGAAPRYPLMDRFEEVYFRIQDLEMFQPGRMHRVGELSGDNYLRSPGGRQLRAALDRFRDWQVRCPDWFECENLYSADDQDAPSLDEEVFEEPLLPPGTGIVKRAPLVREPGSQACLAIDPLVGEEGGAAVAKLEPHLQPRGQPAPQPLHTLVLAAEEGALVAAVEPGPLADGAAVRLALAGEGEACPLLGSPGAGRNSVLFLPVDPEDSPLGSSTPMASPDLLPEDVREHLEGLMLSLFEQSLSCQAQGGCSRPAMVLTDPHTPYEEEQRQSVQSDQGYISRSSPQPPEGLTEMEEEEEEEQDPGKPALPLSPEDLESLRSLQRQLLFRQLQKNSGWDTMGSESEGPSA
  
Inhibitor
Name:
BDBM548009
Synonyms:
2,4-dimethyl-3-(4-((S)-2-(1-methyl-1H-pyrazole-5-carboxamido)-2-((1r,4S)-4- methylcyclohexyl)acetamido)phenyl)pyridine 1-oxide | WO2022091056, Example 3
Type:
Small organic molecule
Emp. Form.:
C27H33N5O3
Mol. Mass.:
475.5826
SMILES:
C[C@H]1CC[C@@H](CC1)[C@H](NC(=O)c1ccnn1C)C(=O)Nc1ccc(cc1)-c1c(C)cc[n+]([O-])c1C |r,wU:7.8,1.0,wD:4.7,(1.79,-5.5,;1.79,-3.96,;.46,-3.19,;.46,-1.65,;1.79,-.88,;3.13,-1.65,;3.13,-3.19,;1.79,.66,;3.13,1.43,;3.13,2.97,;1.79,3.74,;4.46,3.74,;4.62,5.28,;6.13,5.6,;6.9,4.26,;5.87,3.12,;6.19,1.61,;.46,1.43,;.46,2.97,;-.88,.66,;-2.21,1.43,;-2.21,2.97,;-3.54,3.74,;-4.88,2.97,;-4.88,1.43,;-3.54,.66,;-6.21,3.74,;-6.21,5.28,;-4.88,6.05,;-7.54,6.05,;-8.88,5.28,;-8.88,3.74,;-10.21,2.97,;-7.54,2.97,;-7.54,1.43,)|
Structure:
Search PDB for entries with ligand similarity: