Target
Interleukin-17 receptor A/
Ligand
BDBM548036
Substrate
n/a
Meas. Tech.
Human IL-17A x IL-17RA TR-FRET assay
IC50
20±n/a nM
Citation
 Josef, TTDavid, OPascal, FKlaus, WAchim, S INTERLEUKIN-17 INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Interleukin-17 receptor A/
Synonyms:
Human IL-17A/IL-17RA | Interleukin-17A/Interleukin-17 receptor A
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Interleukin-17A
Synonyms:
CTLA8 | Cytotoxic T-lymphocyte-associated antigen 8 | IL-17 | IL17 | IL17A | IL17_HUMAN | il-17a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17511.44
Organism:
Homo sapiens (Human)
Description:
Q16552
Residue:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  
Component 2
Name:
Interleukin-17 receptor A
Synonyms:
CDw217 | I17RA_HUMAN | IL-17 receptor A | IL-17RA | IL17R | IL17RA
Type:
Protein
Mol. Mass.:
96092.10
Organism:
Human
Description:
Q96F46
Residue:
866
Sequence:
MGAARSPPSAVPGPLLGLLLLLLGVLAPGGASLRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLWVYWFITGISILLVGSVILLIVCMTWRLAGPGSEKYSDDTKYTDGLPAADLIPPPLKPRKVWIIYSADHPLYVDVVLKFAQFLLTACGTEVALDLLEEQAISEAGVMTWVGRQKQEMVESNSKIIVLCSRGTRAKWQALLGRGAPVRLRCDHGKPVGDLFTAAMNMILPDFKRPACFGTYVVCYFSEVSCDGDVPDLFGAAPRYPLMDRFEEVYFRIQDLEMFQPGRMHRVGELSGDNYLRSPGGRQLRAALDRFRDWQVRCPDWFECENLYSADDQDAPSLDEEVFEEPLLPPGTGIVKRAPLVREPGSQACLAIDPLVGEEGGAAVAKLEPHLQPRGQPAPQPLHTLVLAAEEGALVAAVEPGPLADGAAVRLALAGEGEACPLLGSPGAGRNSVLFLPVDPEDSPLGSSTPMASPDLLPEDVREHLEGLMLSLFEQSLSCQAQGGCSRPAMVLTDPHTPYEEEQRQSVQSDQGYISRSSPQPPEGLTEMEEEEEEEQDPGKPALPLSPEDLESLRSLQRQLLFRQLQKNSGWDTMGSESEGPSA
  
Inhibitor
Name:
BDBM548036
Synonyms:
WO2022091056, Example 28
Type:
Small organic molecule
Emp. Form.:
C27H29FN4O4
Mol. Mass.:
492.542
SMILES:
CCc1nocc1C(=O)N[C@@H]([C@H]1CCC(F)=CC1)C(=O)Nc1ccc(cc1)-c1c(C)cc[n+]([O-])c1C |r,c:16|
Structure:
Search PDB for entries with ligand similarity: