Target
Interleukin-17 receptor A/
Ligand
BDBM548116
Substrate
n/a
Meas. Tech.
Human IL-17A x IL-17RA TR-FRET assay
IC50
19±n/a nM
Citation
 Josef, TTDavid, OPascal, FKlaus, WAchim, S INTERLEUKIN-17 INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Interleukin-17 receptor A/
Synonyms:
Human IL-17A/IL-17RA | Interleukin-17A/Interleukin-17 receptor A
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Interleukin-17A
Synonyms:
CTLA8 | Cytotoxic T-lymphocyte-associated antigen 8 | IL-17 | IL17 | IL17A | IL17_HUMAN | il-17a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17511.44
Organism:
Homo sapiens (Human)
Description:
Q16552
Residue:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  
Component 2
Name:
Interleukin-17 receptor A
Synonyms:
CDw217 | I17RA_HUMAN | IL-17 receptor A | IL-17RA | IL17R | IL17RA
Type:
Protein
Mol. Mass.:
96092.10
Organism:
Human
Description:
Q96F46
Residue:
866
Sequence:
MGAARSPPSAVPGPLLGLLLLLLGVLAPGGASLRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLWVYWFITGISILLVGSVILLIVCMTWRLAGPGSEKYSDDTKYTDGLPAADLIPPPLKPRKVWIIYSADHPLYVDVVLKFAQFLLTACGTEVALDLLEEQAISEAGVMTWVGRQKQEMVESNSKIIVLCSRGTRAKWQALLGRGAPVRLRCDHGKPVGDLFTAAMNMILPDFKRPACFGTYVVCYFSEVSCDGDVPDLFGAAPRYPLMDRFEEVYFRIQDLEMFQPGRMHRVGELSGDNYLRSPGGRQLRAALDRFRDWQVRCPDWFECENLYSADDQDAPSLDEEVFEEPLLPPGTGIVKRAPLVREPGSQACLAIDPLVGEEGGAAVAKLEPHLQPRGQPAPQPLHTLVLAAEEGALVAAVEPGPLADGAAVRLALAGEGEACPLLGSPGAGRNSVLFLPVDPEDSPLGSSTPMASPDLLPEDVREHLEGLMLSLFEQSLSCQAQGGCSRPAMVLTDPHTPYEEEQRQSVQSDQGYISRSSPQPPEGLTEMEEEEEEEQDPGKPALPLSPEDLESLRSLQRQLLFRQLQKNSGWDTMGSESEGPSA
  
Inhibitor
Name:
BDBM548116
Synonyms:
WO2022091056, Example 107
Type:
Small organic molecule
Emp. Form.:
C25H25ClF3N5O3
Mol. Mass.:
535.946
SMILES:
Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)C2CCC(F)(F)CC2)cc1F |r,wU:16.17,(-7.54,1.43,;-7.54,2.97,;-6.21,3.74,;-6.21,5.28,;-4.88,6.05,;-7.54,6.05,;-8.88,5.28,;-8.88,3.74,;-10.21,2.97,;-4.88,2.97,;-3.54,3.74,;-2.21,2.97,;-2.21,1.43,;-.87,.66,;.46,1.43,;.46,2.97,;1.79,.66,;3.13,1.43,;3.13,2.97,;1.79,3.74,;4.46,3.74,;4.62,5.27,;6.13,5.59,;6.9,4.26,;5.87,3.12,;6.19,1.61,;1.79,-.88,;.46,-1.65,;.46,-3.19,;1.79,-3.96,;.46,-4.73,;3.13,-4.73,;3.13,-3.19,;3.13,-1.65,;-3.54,.66,;-4.88,1.43,;-6.21,.66,)|
Structure:
Search PDB for entries with ligand similarity: