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Target
Three-prime repair exonuclease 1
Ligand
BDBM550470
Substrate
n/a
IC50
<1000±n/a nM
Citation
 Letourneau, JJ; Selvarangan Elamparuthi, K; Huang, C; Bommireddy Venkata, V Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors US Patent  US11306098 Publication Date 4/19/2022 
Target
Name:
Three-prime repair exonuclease 1
Synonyms:
3'-5' exonuclease TREX1 | TREX1_MOUSE | Trex1
Type:
Protein
Mol. Mass.:
33681.13
Organism:
Mouse
Description:
Q91XB0
Residue:
314
Sequence:
MGSQTLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAALKALEQASSPSGNGSRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALLQWVDEHARPFSTVKPMYGTPATTGTTNLRPHAATATTPLATANGSPSNGRSRRPKSPPPEKVPEAPSQEGLLAPLSLLTLLTLAIATLYGLFLASPGQ
  
Inhibitor
Name:
BDBM550470
Synonyms:
US11306098, Example 36 | US11583538, Example 118
Type:
Small organic molecule
Emp. Form.:
C28H34Cl2N8O2
Mol. Mass.:
585.528
SMILES:
N[C@@H]1C[C@@H]2N(C1)C(CCc1ccccc1)CCN([C@H](CCc1nnn[nH]1)C(=O)NCc1ccc(Cl)c(Cl)c1)C2=O
Structure:
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