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Target
Hsp90 chaperone protein kinase-targeting subunit
Ligand
BDBM551758
Substrate
n/a
Meas. Tech.
FP-based equilibrium competition assay
EC50
23.0±n/a nM
Citation
 Brown, LE; Huang, DS; Cowen, LE; Whitesell, L; Marcyk, P Hsp90 inhibitors and uses thereof US Patent  US11312722 Publication Date 4/26/2022 
Target
Name:
Hsp90 chaperone protein kinase-targeting subunit
Synonyms:
F5H9H0_CRYNB
Type:
Protein
Mol. Mass.:
57233.28
Organism:
Filobasidiella neoformans
Description:
F5H9H0
Residue:
505
Sequence:
MPLNYSKWDMLELSDDSDIEEHPNVDKKSMIRWKQRDIHEKREARKLLISKLKSELSLNSVLRPRIETIISGLSSSGLDHYRAVQRRMKEDPSPEKPETGAPNQPTYDMMLSQLLSDVFREGAWLVEGGRIEGNGVLYNGKKVDDNTGLPDWATAEVPEGKKELLAEKLEQRLRWHVSELNRRDEQVKKEIEKEEGELKKKITSDDIHEGWSSSKIAPPKPSVWDETPRPKKDKKTEKVETIEVLNPKASSSAAPVAPATEDTDDEEDFGPLSPAGRAFAQIPLGDFEKAYDFIKNDSSVLSSSTHDSLLAEAFDAERRGDKSLAMRCVHQSLLVNYCRQLGKDGVGLFFQKMIQKNPKSITMFNEDFQRTYNRIATRTREILAEEAAAGPSGEREQIQLVATDPNMTIAFNLPDGPPPEKILLEGEGVEELDMEQVRAWLQRKWEIFKSFPPRFQEALQTENLDKVNQALGDMKVSEAEKIVELLQEGGMLSFSEKGVRDMTNQ
  
Inhibitor
Name:
BDBM551758
Synonyms:
US11312722, Compound 48
Type:
Small organic molecule
Emp. Form.:
C27H30N6O4
Mol. Mass.:
502.5649
SMILES:
COc1ccc(Cn2nc(cc2Nc2cc(O)cc(O)c2C(=O)N2Cc3cn[nH]c3C2)C(C)(C)C)cc1
Structure:
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