Reaction Details
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Hsp90 chaperone protein kinase-targeting subunit
Ligand
BDBM551774
Substrate
n/a
Meas. Tech.
FP-based equilibrium competition assay
EC50
41.0±n/a nM
Citation
Brown, LE; Huang, DS; Cowen, LE; Whitesell, L; Marcyk, P Hsp90 inhibitors and uses thereof US Patent US11312722 Publication Date 4/26/2022 More Info.:
Target
Name:
Hsp90 chaperone protein kinase-targeting subunit
Synonyms:
F5H9H0_CRYNB
Type:
Protein
Mol. Mass.:
57233.28
Organism:
Filobasidiella neoformans
Description:
F5H9H0
Residue:
505
Sequence:
MPLNYSKWDMLELSDDSDIEEHPNVDKKSMIRWKQRDIHEKREARKLLISKLKSELSLNSVLRPRIETIISGLSSSGLDHYRAVQRRMKEDPSPEKPETGAPNQPTYDMMLSQLLSDVFREGAWLVEGGRIEGNGVLYNGKKVDDNTGLPDWATAEVPEGKKELLAEKLEQRLRWHVSELNRRDEQVKKEIEKEEGELKKKITSDDIHEGWSSSKIAPPKPSVWDETPRPKKDKKTEKVETIEVLNPKASSSAAPVAPATEDTDDEEDFGPLSPAGRAFAQIPLGDFEKAYDFIKNDSSVLSSSTHDSLLAEAFDAERRGDKSLAMRCVHQSLLVNYCRQLGKDGVGLFFQKMIQKNPKSITMFNEDFQRTYNRIATRTREILAEEAAAGPSGEREQIQLVATDPNMTIAFNLPDGPPPEKILLEGEGVEELDMEQVRAWLQRKWEIFKSFPPRFQEALQTENLDKVNQALGDMKVSEAEKIVELLQEGGMLSFSEKGVRDMTNQ
Inhibitor
Name:
BDBM551774
Synonyms:
US11312722, Compound 64
Type:
Small organic molecule
Emp. Form.:
C19H22N6O3
Mol. Mass.:
382.4164
SMILES:
CC(C)(C)n1nccc1Nc1cc(O)cc(O)c1C(=O)N1Cc2cn[nH]c2C1
Structure:
