Reaction Details Report a problem with these data
Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM563272
Substrate
n/a
Meas. Tech.
LpxC Binding Assay
IC50
30±n/a nM
Citation
 Teng, M; Nammalwar, B; Li, X; Perez, C; Yule, I; Faulkner, A; Atton, H; Parkes, A; Convers-Reignier, S; Southey, M; Puerta, DT Antibacterial compounds US Patent  US11407740 Publication Date 8/9/2022 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC
Type:
Enzyme
Mol. Mass.:
33952.00
Organism:
Escherichia coli
Description:
P0A725
Residue:
305
Sequence:
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
  
Inhibitor
Name:
BDBM563272
Synonyms:
US11407740, Compound 177
Type:
Small organic molecule
Emp. Form.:
C29H32N4O3
Mol. Mass.:
484.5894
SMILES:
Oc1c(CC(CN2CCC2)c2ccc(cc2)C#Cc2ccc(CN3CCOCC3)cc2)nc[nH]c1=O
Structure:
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