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Target
Kelch-like ECH-associated protein 1 [321-624]
Ligand
BDBM570283
Substrate
n/a
Meas. Tech.
Fluorescence Based Assay
Kd
<1.000±n/a nM
Citation
 Barbay, JK; Chai, W; Hirst, GC; Kreutter, KD; Kummer, DA; McClure, KJ; Nishimura, RT; Shih, AY; Venable, JD; Venkatesan, H; Wei, J Inhibitors of KEAP1-Nrf2 protein-protein interaction US Patent  US11427601 Publication Date 8/30/2022
Target
Name:
Kelch-like ECH-associated protein 1 [321-624]
Synonyms:
KEAP1 | KEAP1_PONAB | Kelch-like ECH-associated protein 1 (KEAP1)(321-624)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
33399.63
Organism:
Homo sapiens (Human)
Description:
aa 321-624
Residue:
304
Sequence:
APKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC
  
Inhibitor
Name:
BDBM570283
Synonyms:
3-(3-(((*S)-5,5-Dioxido-7,7a,8,9,10,11-hexahydro-6H-dipyrido[2,1-d:2′,3′-f][1,2,5]thiadiazepin-6-yl)methyl)-4-methylphenyl)-2-methyl-3-(8-methyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-7-yl)propanoic acid. | US11427601, Example 129
Type:
Small organic molecule
Emp. Form.:
C31H33F3N6O4S
Mol. Mass.:
642.692
SMILES:
CC(C(c1ccc(C)c(CN2C[C@@H]3CCCCN3c3ncccc3S2(=O)=O)c1)c1ccn2c(nnc2c1C)C(F)(F)F)C(O)=O |r|
Structure:
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