Reaction Details Report a problem with these data
Target
Envelope glycoprotein
Ligand
BDBM574749
Substrate
n/a
Meas. Tech.
Inhibition of Infectivity of Recombinant VSVs Expressing Glycoproteins from Zaire Ebolavirus, Sudan Ebolavirus, Bundybugyo Ebolavirus, and Lassa Arenavirus
IC50
1500±n/a nM
Citation
 Bowlin, TL; Moir, DT; Chandran, K; Dye, Jr., JM; Williams, JD; Aron, ZD; Barbor, JP; Lively, KN; Nash, PJ; Mills, DM; Basu, A Broad spectrum inhibitors of filoviruses US Patent  US11459308 Publication Date 10/4/2022 
Target
Name:
Envelope glycoprotein
Synonyms:
GP | GP1,2 | VGP_EBORS | rVSV-EBOV
Type:
Protein
Mol. Mass.:
74522.01
Organism:
REBOV
Description:
Q89853
Residue:
677
Sequence:
MGSGYQLLQLPRERFRKTSFLVWVIILFQRAISMPLGIVTNSTLKATEIDQLVCRDKLSSTSQLKSVGLNLEGNGIATDVPSATKRWGFRSGVPPKVVSYEAGEWAENCYNLEIKKSDGSECLPLPPDGVRGFPRCRYVHKVQGTGPCPGDLAFHKNGAFFLYDRLASTVIYRGTTFTEGVVAFLILSEPKKHFWKATPAHEPVNTTDDSTSYYMTLTLSYEMSNFGGKESNTLFKVDNHTYVQLDRPHTPQFLVQLNETLRRNNRLSNSTGRLTWTLDPKIEPDVGEWAFWETKKNFSQQLHGENLHFQILSTHTNNSSDQSPAGTVQGKISYHPPTNNSELVPTDSPPVVSVLTAGRTEEMSTQGLTNGETITGFTANPMTTTIAPSPTMTSEVDNNVPSEQPNNTASIEDSPPSASNETIDHSEMNPIQGSNNSAQSPQTKTTPAPTASPMTQDPQETANSSKLGTSPGSAAEPSQPGFTINTVSKVADSLSPTRKQKRSVRQNTANKCNPDLHYWTAVDEGAAVGLAWIPYFGPAAEGIYIEGVMHNQNGLICGLRQLANETTQALQLFLRATTELRTYSLLNRKAIDFLLQRWGGTCRILGPSCCIEPHDWTKNITDEINQIKHDFIDNPLPDHGDDLNLWTGWRQWIPAGIGIIGVIIAIIALLCICKILC
  
Inhibitor
Name:
BDBM574749
Synonyms:
US11459308, Compound 3561
Type:
Small organic molecule
Emp. Form.:
C29H29N5O2
Mol. Mass.:
479.5729
SMILES:
[O-][N+](=O)c1ccc(cc1NC(c1ccccc1)c1ccccc1)N1CCN(Cc2ccncc2)CC1
Structure:
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