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Target
Envelope glycoprotein
Ligand
BDBM50223308
Substrate
n/a
Meas. Tech.
Inhibition of Infectivity of Recombinant VSVs Expressing Glycoproteins from Zaire Ebolavirus, Sudan Ebolavirus, Bundybugyo Ebolavirus, and Lassa Arenavirus
IC50
1200±n/a nM
Citation
 Bowlin, TL; Moir, DT; Chandran, K; Dye, Jr., JM; Williams, JD; Aron, ZD; Barbor, JP; Lively, KN; Nash, PJ; Mills, DM; Basu, A Broad spectrum inhibitors of filoviruses US Patent  US11459308 Publication Date 10/4/2022 
Target
Name:
Envelope glycoprotein
Synonyms:
GP | GP1,2 | VGP_EBORS | rVSV-EBOV
Type:
Protein
Mol. Mass.:
74522.01
Organism:
REBOV
Description:
Q89853
Residue:
677
Sequence:
MGSGYQLLQLPRERFRKTSFLVWVIILFQRAISMPLGIVTNSTLKATEIDQLVCRDKLSSTSQLKSVGLNLEGNGIATDVPSATKRWGFRSGVPPKVVSYEAGEWAENCYNLEIKKSDGSECLPLPPDGVRGFPRCRYVHKVQGTGPCPGDLAFHKNGAFFLYDRLASTVIYRGTTFTEGVVAFLILSEPKKHFWKATPAHEPVNTTDDSTSYYMTLTLSYEMSNFGGKESNTLFKVDNHTYVQLDRPHTPQFLVQLNETLRRNNRLSNSTGRLTWTLDPKIEPDVGEWAFWETKKNFSQQLHGENLHFQILSTHTNNSSDQSPAGTVQGKISYHPPTNNSELVPTDSPPVVSVLTAGRTEEMSTQGLTNGETITGFTANPMTTTIAPSPTMTSEVDNNVPSEQPNNTASIEDSPPSASNETIDHSEMNPIQGSNNSAQSPQTKTTPAPTASPMTQDPQETANSSKLGTSPGSAAEPSQPGFTINTVSKVADSLSPTRKQKRSVRQNTANKCNPDLHYWTAVDEGAAVGLAWIPYFGPAAEGIYIEGVMHNQNGLICGLRQLANETTQALQLFLRATTELRTYSLLNRKAIDFLLQRWGGTCRILGPSCCIEPHDWTKNITDEINQIKHDFIDNPLPDHGDDLNLWTGWRQWIPAGIGIIGVIIAIIALLCICKILC
  
Inhibitor
Name:
BDBM50223308
Synonyms:
CHEMBL398481 | N-benzhydryl-5-(4-methylpiperazin-1-yl)-2-nitrobenzenamine | US11459308, Compound PPZ-1
Type:
Small organic molecule
Emp. Form.:
C24H26N4O2
Mol. Mass.:
402.4888
SMILES:
CN1CCN(CC1)c1ccc(c(NC(c2ccccc2)c2ccccc2)c1)[N+]([O-])=O
Structure:
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