Reaction Details Report a problem with these data
Target
Non-receptor tyrosine-protein kinase TYK2 [556-871]
Ligand
BDBM576251
Substrate
n/a
Meas. Tech.
Probe Displacement Assay
IC50
6.00±n/a nM
Citation
 Tami, M; Dale, R; Brock, S; Jocelyn, W INHIBITION OF TYK2 DEPENDENT SIGNALING PATHWAYS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-871]
Synonyms:
TYK2 | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
35197.67
Organism:
Homo sapiens (Human)
Description:
P29597[556-871]
Residue:
316
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQP
  
Inhibitor
Name:
BDBM576251
Synonyms:
WO2022109580, Example 12
Type:
Small organic molecule
Emp. Form.:
C21H26N6O5
Mol. Mass.:
442.4683
SMILES:
CO[C@@]1(CCOC1)c1cc(OC[C@@H](C)O)cc(n1)-n1nc(C)c2cnc(NC(N)=O)cc12 |r|
Structure:
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