Reaction Details Report a problem with these data
Target
Non-receptor tyrosine-protein kinase TYK2 [556-871]
Ligand
BDBM576261
Substrate
n/a
Meas. Tech.
Probe Displacement Assay
IC50
42±n/a nM
Citation
 Tami, M; Dale, R; Brock, S; Jocelyn, W INHIBITION OF TYK2 DEPENDENT SIGNALING PATHWAYS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-871]
Synonyms:
TYK2 | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
35197.67
Organism:
Homo sapiens (Human)
Description:
P29597[556-871]
Residue:
316
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQP
  
Inhibitor
Name:
BDBM576261
Synonyms:
WO2022109580, Example 24
Type:
Small organic molecule
Emp. Form.:
C22H25N8O3
Mol. Mass.:
449.4857
SMILES:
CO[C@@]1(CCOC1)c1cc(C)cc(n1)-n1cc(-c2cnn(C)c2)n2cnc(NC(N)=O)cc12
Structure:
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